Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1974 Aug;27(8):643–646. doi: 10.1136/jcp.27.8.643

The plasma cells in inflammatory disease of the colon: A quantitative study

J M Skinner 1, R Whitehead 1
PMCID: PMC475420  PMID: 4608917

Abstract

Immunoglobulin-containing cells have been counted in the mucosa of colectomy specimens from patients with ulcerative colitis and Crohn's disease. An increase in IgA cells occurs in both when compared with normal. In Crohn's colitis the increase is significantly higher than in ulcerative colitis. The importance of these findings in relation to pathogenesis is discussed.

Full text

PDF
644

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROBERGER O., PERLMANN P. Autoantibodies in human ulcerative colitis. J Exp Med. 1959 Nov 1;110:657–674. doi: 10.1084/jem.110.5.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BROBERGER O., PERLMANN P. Demonstration of an epithelial antigen in colon by means of fluorescent antibodies from children with ulcerative colitis. J Exp Med. 1962 Jan 1;115:13–26. doi: 10.1084/jem.115.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Campbell A. C., Hersey P., Harding B., Hollingsworth P. M., Skinner J., MacLennan I. C. Effects of anti-cancer agents on immunological status. Br J Cancer Suppl. 1973 Aug;1:254–261. [PMC free article] [PubMed] [Google Scholar]
  4. Crabbé P. A., Heremans J. F. The distribution of immunoglobulin-containing cells along the human gastrointestinal tract. Gastroenterology. 1966 Sep;51(3):305–316. [PubMed] [Google Scholar]
  5. Doe W. F., Booth C. C., Brown D. L. Evidence for complement-binding immune complexes in adult coeliac disease, Crohn's disease, and ulcerative colitis. Lancet. 1973 Feb 24;1(7800):402–403. doi: 10.1016/s0140-6736(73)90254-7. [DOI] [PubMed] [Google Scholar]
  6. Fletcher J., Hinton J. M. Tuberculin sensitivity in Crohn's disease. A controlled study. Lancet. 1967 Oct 7;2(7519):753–754. doi: 10.1016/s0140-6736(67)91949-6. [DOI] [PubMed] [Google Scholar]
  7. Hinz C. F., Jr, Perlmann P., Hammarström S. Reactivity in vitro of lymphocytes from patients with ulcerative colitis. J Lab Clin Med. 1967 Nov;70(5):752–759. [PubMed] [Google Scholar]
  8. Jewell D. P., MacLennan I. C. Circulating immune complexes in inflammatory bowel disease. Clin Exp Immunol. 1973 Jun;14(2):219–226. [PMC free article] [PubMed] [Google Scholar]
  9. Jones J. V., Housley J., Ashurst P. M., Hawkins C. F. Development of delayed hypersensitivity to dinitrochlorobenzene in patients with Crohn's disease. Gut. 1969 Jan;10(1):52–56. doi: 10.1136/gut.10.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LOCKHART-MUMMERY H. E., MORSON B. C. Crohn's disease (regional enteritis) of the large intestine and its distinction from ulcerative colitis. Gut. 1960 Jun;1:87–105. doi: 10.1136/gut.1.2.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lagercrantz R., Hammarström S., Perlmann P., Gustafsson B. E. Immunological studies in ulcerative colitis. IV. Origin of autoantibodies. J Exp Med. 1968 Dec 1;128(6):1339–1352. doi: 10.1084/jem.128.6.1339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marcussen H., Nerup J. Fluorescent anti-colon and organ-specific antibodies in ulcerative colitis. Scand J Gastroenterol. 1973;8(1):9–15. [PubMed] [Google Scholar]
  13. Mitchell D. N., Cannon P., Dyer N. H., Hinson K. F., Willoughby J. M. Further observations on Kveim test in Crohn's disease. Lancet. 1970 Sep 5;2(7671):496–498. doi: 10.1016/s0140-6736(70)90114-5. [DOI] [PubMed] [Google Scholar]
  14. Shorter R. G., Spencer R. J., Huizenga K. A., Hallenbeck G. A. Inhibition of in vitro cytotoxicity of lymphocytes from patients with ulcerative colitis and granulomatous colitis for allogeneic colonic epithelial cells using horse anti-human thymus serum. Gastroenterology. 1968 Feb;54(2):227–231. [PubMed] [Google Scholar]
  15. Siltzbach L. E., Vieira L. O., Topilsky M., Janowitz H. D. Is there Kveim responsiveness in Crohn's disease? Lancet. 1971 Sep 18;2(7725):634–636. doi: 10.1016/s0140-6736(71)80072-7. [DOI] [PubMed] [Google Scholar]
  16. Skinner J. M., Whitehead R. A morphological assessment of immunoreactivity in colonic Crohn's disease and ulcerative colitis by a study of the lymph nodes. J Clin Pathol. 1974 Mar;27(3):202–206. doi: 10.1136/jcp.27.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Spector W. G., Heesom N. The production of granulomata by antigen-antibody complexes. J Pathol. 1969 May;98(1):31–39. doi: 10.1002/path.1710980105. [DOI] [PubMed] [Google Scholar]
  18. Stefani S., Fink S. The ulcerative colitis lymphocyte: reaction to E. coli O 14 and colon antigens. Scand J Gastroenterol. 1967;2(4):333–336. doi: 10.3109/00365526709180092. [DOI] [PubMed] [Google Scholar]
  19. TAYLOR K. B., TRUELOVE S. C. Circulating antibodies to milk proteins in ulcerative colitis. Br Med J. 1961 Oct 7;2(5257):924–929. doi: 10.1136/bmj.2.5257.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Thayer W. R., Jr, Brown M., Sangree M. H., Katz J., Hersh T. Escherichia Coli O:14 and colon hemagglutinating antibodies in inflammatory bowel disease. Gastroenterology. 1969 Sep;57(3):311–318. [PubMed] [Google Scholar]
  21. Tomasi T. B., Jr Human immunoglobulin A. N Engl J Med. 1968 Dec 12;279(24):1327–1330. doi: 10.1056/NEJM196812122792408. [DOI] [PubMed] [Google Scholar]
  22. WEIBEL E. R. Principles and methods for the morphometric study of the lung and other organs. Lab Invest. 1963 Feb;12:131–155. [PubMed] [Google Scholar]
  23. WRIGHT R., TRUELOVE S. C. CIRCULATING ANTIBODIES TO DIETARY PROTEINS IN ULCERATIVE COLITIS. Br Med J. 1965 Jul 17;2(5454):142–144. doi: 10.1136/bmj.2.5454.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Watson D. W., Quigley A., Bolt R. J. Effect of lymphocytes from patients with ulcerative colitis on human adult colon epithelial cells. Gastroenterology. 1966 Dec;51(6):985–993. [PubMed] [Google Scholar]
  25. Wright R., Truelove S. C. Auto-immune reactions in ulcerative colitis. Gut. 1966 Feb;7(1):32–40. doi: 10.1136/gut.7.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES