Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1974 Sep;27(9):698–709. doi: 10.1136/jcp.27.9.698

A light and electron microscopic study of the liver in case of erythrohepatic protoporphyria and in griseofulvin-induced porphyria in mice

A Matilla 1, Elizabeth A Molland 1
PMCID: PMC475441  PMID: 4372253

Abstract

The light- and electron-microscopic appearances of a liver biopsy from a case of erythrohepatic protoporphyria are compared with the appearances of the liver in griseofulvin-induced porphyria in mice. Crystals are present in hepatocytes and in the bile secretory pathways in each case. The nature and significance of these is discussed.

Full text

PDF
703

Images in this article

699Image
on p.699
699Image
on p.699
700Image
on p.700
701Image
on p.701
701Image
on p.701
702Image
on p.702
702Image
on p.702
703Image
on p.703
703Image
on p.703
704Image
on p.704
705Image
on p.705
705Image
on p.705
706Image
on p.706
706Image
on p.706
707Image
on p.707

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes H. D., Hurworth E., Millar J. H. Erythropoietic porphyrin hepatitis. J Clin Pathol. 1968 Mar;21(2):157–159. doi: 10.1136/jcp.21.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cripps D. J., MacEachern W. N. Hepatic and erythropoietic protoporphyria. Delta-aminolevulinic acid synthetase, fluorescence, and microfluorospectrophotometric study. Arch Pathol. 1971 Jun;91(6):497–505. [PubMed] [Google Scholar]
  3. Cripps D. J., Scheuer P. J. Hepatobiliary changes in erythropoietic protoporphyria. Arch Pathol. 1965 Nov;80(5):500–508. [PubMed] [Google Scholar]
  4. DE MATTEIS F., RIMINGTON C. Disturbance of porphyrin metabolism caused by griseofulvin in mice. Br J Dermatol. 1963 Mar;75:91–104. doi: 10.1111/j.1365-2133.1963.tb13945.x. [DOI] [PubMed] [Google Scholar]
  5. Donaldson E. M., McCall A. J., Magnus I. A., Simpson J. R., Caldwell R. A., Hargreaves T. Erythropoietic protoporphyria: two deaths from hepatic cirrhosis. Br J Dermatol. 1971 Jan;84(1):14–24. doi: 10.1111/j.1365-2133.1971.tb14191.x. [DOI] [PubMed] [Google Scholar]
  6. GRANICK S., URATA G. Increase in activity of alpha-aminolevulinic acid synthetase in liver mitochondria induced by feeding of 3,5-dicarbethoxy-1,4-dihydrocollidine. J Biol Chem. 1963 Feb;238:821–827. [PubMed] [Google Scholar]
  7. GRAY C. H., KULCZYCKA A., NICHOLSON D. C., MAGNUS I. A., RIMINGTON C. ISOTOPE STUDIES ON A CASE OF ERYTHROPOIETIC PROTOPORPHYRIA. Clin Sci. 1964 Feb;26:7–15. [PubMed] [Google Scholar]
  8. Granick S. The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals. J Biol Chem. 1966 Mar 25;241(6):1359–1375. [PubMed] [Google Scholar]
  9. Janousek V. The early changes in experimental porphyria of mice induced by griseofulvin. Trans St Johns Hosp Dermatol Soc. 1970;56(1):14–18. [PubMed] [Google Scholar]
  10. MAGNUS I. A., JARRETT A., PRANKERD T. A., RIMINGTON C. Erythropoietic protoporphyria. A new porphyria syndrome with solar urticaria due to protoporphyrinaemia. Lancet. 1961 Aug 26;2(7200):448–451. doi: 10.1016/s0140-6736(61)92427-8. [DOI] [PubMed] [Google Scholar]
  11. MAGNUS I. A., PORTER A. D., MCCREE K. J., MORELAND J. D., WRIGHT W. D. A monochromator. An apparatus for the investigation of the responses of the skin to ultra-violet, visible and near infra-red radiation. Br J Dermatol. 1959 Jul;71:261–266. doi: 10.1111/j.1365-2133.1959.tb13422.x. [DOI] [PubMed] [Google Scholar]
  12. Magnus I. A., Roe D. A., Bhutani L. K. Factors affecting the induction of porphyria in the laboratory rat. Biochemical and photobiological studies using diethyl 1,4-dihydro-2,4,6-trimethyl-pyridine-3,5-dicarboxylate (DDC) as a porphyrogenic agent. J Invest Dermatol. 1969 Dec;53(6):400–413. doi: 10.1038/jid.1969.167. [DOI] [PubMed] [Google Scholar]
  13. Nakao K., Wada O., Takaku F., Sassa S., Yano Y., Urata G. The origin of the increased protoporphyrin in erythrocytes of mice with experimentally induced porphyria. J Lab Clin Med. 1967 Dec;70(6):923–932. [PubMed] [Google Scholar]
  14. PORTER F. S., LOWE B. A. CONGENITAL ERYTHROPOIETIC PROTOPORPHYRIA. I. CASE REPORTS, CLINICAL STUDIES AND PORPHYRIN ANALYSES IN TWO BROTHERS. Blood. 1963 Nov;22:521–531. [PubMed] [Google Scholar]
  15. Roe D. A., Krook L., Wilkie B. N. Hepatic protoporphyria in weanling pigs. J Invest Dermatol. 1970 Jan;54(1):53–64. doi: 10.1111/1523-1747.ep12551671. [DOI] [PubMed] [Google Scholar]
  16. SCHMID R., SCHWARTZ S., WATSON C. J. Porphyrin content of bone marrow and liver in the various forms of porphyria. AMA Arch Intern Med. 1954 Feb;93(2):167–190. doi: 10.1001/archinte.1954.00240260001001. [DOI] [PubMed] [Google Scholar]
  17. Schmidt D., Stich W. Erythropoetische Protoporphyrie mit Porphyrinurie. Untersuchungen zur Frage der Leberbeteiligung bei erythropoetischer Protoporphyrie. Blut. 1971 Apr;22(4):202–210. doi: 10.1007/BF01633615. [DOI] [PubMed] [Google Scholar]
  18. Thompson R. P., Molland E. A., Nicholson D. C., Gray C. H. 'Erythropoietic' protoporphyria and cirrhosis in sisters. Gut. 1973 Dec;14(12):934–938. doi: 10.1136/gut.14.12.934. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Waterfield M. D., Del Favero A., Palfrey A. J. Electron-microscopic changes in the livers of mice treated with the porphyrinogenic agent 1,4-dihydro-3,5-dicarbethoxycollidine. J Pathol. 1969 Jun;98(2):151–154. doi: 10.1002/path.1710980210. [DOI] [PubMed] [Google Scholar]
  20. Zimmerman T. S., McMillin J. M., Watson C. J. Onset of manifestations of hepatic porphyria in relation to the influence of female sex hormones. Arch Intern Med. 1966 Sep;118(3):229–240. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES