Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1975 Jan;28(1):60–65. doi: 10.1136/jcp.28.1.60

Bronchorrhoea in a case of alveolar cell carcinoma.

S G Spiro, Lopez-Vidriero M-T, J Charman, I Das, L Reid
PMCID: PMC475595  PMID: 164485

Abstract

In a case of bronchorrhoea associated with alveolar cell carcinoma thf rheological and chemical features of the sputum indicated that it was bronchial fluid and not saliva and part bronchial secretion, partly serum transudate. The viscosity and chemical constituents were similar to those found in bronchorrhoea when associated with chronic bronchitis, asthma, or bronchiectasis. The surfactant studies suggested an alveolar origin for most of thf fluid, while the failure of fluid restriction, corticosteroids, atropine, or cytotoxic drugs to influence the sputum volume and properties indicated that the cells responsible are "autonomous".

Full text

PDF
60

Images in this article

61Image
on p.61

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BISERTE G., HAVEZ R., CUVELIER R. LES GLYCOPROT'EIDES DES S'ECR'ETIONS BRONCHIQUES. Expos Annu Biochim Med. 1963;24:85–120. [PubMed] [Google Scholar]
  2. BUKANTZ S. C., BERNS A. W. Studies with sputum. III. Paper electrophoresis and gel diffusion of sputum in the diagnosis of pulmonary carcinomatosis. Identification of the fast-moving component as albumin. Am Rev Respir Dis. 1962 Mar;85:351–363. doi: 10.1164/arrd.1962.85.3.351. [DOI] [PubMed] [Google Scholar]
  3. Brogan T. D., Ryley H. C., Allen L., Hutt H. Relation between sputum sol phase composition and diagnosis in chronic chest diseases. Thorax. 1971 Jul;26(4):418–423. doi: 10.1136/thx.26.4.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Doumas B. T., Watson W. A., Biggs H. G. Albumin standards and the measurement of serum albumin with bromcresol green. Clin Chim Acta. 1971 Jan;31(1):87–96. doi: 10.1016/0009-8981(71)90365-2. [DOI] [PubMed] [Google Scholar]
  5. GERNEZ-RIEUX C., BISERTE G., HAVEZ R., VOISIN C., CUVELIER R., ROUSSEL P. INT'ER ET DE L''ETUDE BIOCHIMIQUE DES PROT'EINES DE L'EXPECTORATION DANS LE CANCER BRONCHIOLO-ALV'EOLAIRE. J Fr Med Chir Thorac. 1963 Oct-Dec;17:799–811. [PubMed] [Google Scholar]
  6. GERNEZ-RIEUX C., VOISIN C., MACQUET V., CLAYES C., PIAT G., FOURNIER P. [Alveolar cancer with incoercible bronchorrhea. (Clinical and biological study)]. Lille Med. 1961 Jan;6:3–9. [PubMed] [Google Scholar]
  7. GIBBONS R. A. Chemical properties of two mucoids from bovine cervical mucin. Biochem J. 1959 Oct;73:209–217. doi: 10.1042/bj0730209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GIBBONS R. A., GLOVER F. A. The physicochemical properties of two mucoids from bovine cervical mucin. Biochem J. 1959 Oct;73:217–225. doi: 10.1042/bj0730217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KENNAMER R. Pulmonary adenomatosis; report of a case. J Am Med Assoc. 1951 Mar 17;145(11):815–818. doi: 10.1001/jama.1951.72920290005008b. [DOI] [PubMed] [Google Scholar]
  10. Keal E. E. Biochemistry and rheology of sputum in asthma. Postgrad Med J. 1971 Mar;47(545):171–177. doi: 10.1136/pgmj.47.545.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Keal E. E., Reid L. Neuraminic acid content of sputum in chronic bronchitis. Thorax. 1972 Nov;27(6):643–653. doi: 10.1136/thx.27.6.643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lopez-Vidriero M. T., Charman J., Keal E., De Silva D. J., Reid L. Sputum viscosity: correlation with chemical and clinical features in chronic bronchitis. Thorax. 1973 Jul;28(4):401–408. doi: 10.1136/thx.28.4.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Munies R., Grubb T. C., Caliari R. E. Relationship between sputum viscosity and total sialic acid content. J Pharm Sci. 1968 May;57(5):824–827. doi: 10.1002/jps.2600570522. [DOI] [PubMed] [Google Scholar]
  14. PIERRE-BOURGEOIS, DELARUE J., GARAIX J. P., BRIEN Bronchorrhée hydro-muqueuse incoercible à évolution maligne. J Fr Med Chir Thorac. 1950;4(6):584–589. [PubMed] [Google Scholar]
  15. RUBINSTEIN P., PILHEU J. A. Consideraciones sobre la broncorrea seromucosa. Rev Asoc Med Argent. 1954 Sep 15;68(781-782):471–473. [PubMed] [Google Scholar]
  16. Ryley H. C., Brogan T. D. Quantitative immunoelectrophoretic analysis of the plasma proteins in the sol phase of sputum from patients with chronic bronchitis. J Clin Pathol. 1973 Nov;26(11):852–856. doi: 10.1136/jcp.26.11.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SCHOOLS G. S., RAY E. S. Bronchiolar carcinoma. A case report of bronchoscopic observation of servere bronchorrhea. Dis Chest. 1961 Jun;39:643–645. doi: 10.1378/chest.39.6.643. [DOI] [PubMed] [Google Scholar]
  18. STOREY C. F., KNUDTSON K. P., LAWRENCE B. J. Bronchiolar (alveolar cell) carcinoma of the lung. J Thorac Surg. 1953 Oct;26(4):331–406. [PubMed] [Google Scholar]
  19. TURIAF J., MARLAND P., SORS C. Carcinose alveolaire du poumon radiologiquement muette. J Fr Med Chir Thorac. 1957;11(2):115–125. [PubMed] [Google Scholar]
  20. WARREN L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959 Aug;234(8):1971–1975. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES