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. 1975 Apr;28(4):309–316. doi: 10.1136/jcp.28.4.309

Detection of heterozygotes in both parents of homozygous patients with Von Willebrand's disease.

Y Sultan, J Simeon, J P Caen
PMCID: PMC475697  PMID: 805164

Abstract

Three patients with severe Von Willebrand's disease are shown to be homozygotes. They were born from unaffected parents. New techniques using a factor-VIII-related antigen assay by the Laurell method and a ristocetin-induced platelet aggregation assay demonstrated abnormalities in these two tests in both parents of the probands. Factor-VIII-related of heterogotes could not be differentiated from normal factor-VIII-related antigen by the immunodiffusion technique, crossed immunoelectrophoresis, and filtration on a sepharose 4b column.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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