Abstract
A case of lithium-induced diabetes insipidus is reported. At necropsy microscopy shoed unique and extensive damage to cells lining the distal nephron. It is suggested that these changes represent a specific toxic effect of lithium, reported here for the first time in man.
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- ANGERVALL L., LEHMANN L., BENGTSSON U. THE RENAL CONCENTRATING CAPACITY IN ALBINO RATS AFTER LONG-TERM CONSUMPTION OF PHENACETIN, NAPA (N-ACETYL-P-AMINOPHENOL) AND ACETYLSALICYLIC ACID. Acta Med Scand. 1964 Feb;175:155–160. doi: 10.1111/j.0954-6820.1964.tb00561.x. [DOI] [PubMed] [Google Scholar]
- Chapman A. J., Lewis G. Iatrogenic lithium poisoning: a case report with necropsy findings. J Okla State Med Assoc. 1972 Dec;65(12):491–494. [PubMed] [Google Scholar]
- Evan A. P., Ollerich D. A. The effect of lithium carbonate on the structure of the rat kidney. Am J Anat. 1972 May;134(1):97–106. doi: 10.1002/aja.1001340108. [DOI] [PubMed] [Google Scholar]
- Forrest J. N., Jr, Cohen A. D., Torretti J., Himmelhoch J. M., Epstein F. H. On the mechanism of lithium-induced diabetes insipidus in man and the rat. J Clin Invest. 1974 Apr;53(4):1115–1123. doi: 10.1172/JCI107649. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Giselson N., Heinegard D., Holmberg C. G., Lindberg L. G., Lindstedt E., Lindstedt G., Schersten B. Renal medullary cystic disease or familial juvenile nephronophthisis: a renal tubular disease. Biochemical findings in two siblings. Am J Med. 1970 Feb;48(2):174–184. doi: 10.1016/0002-9343(70)90113-0. [DOI] [PubMed] [Google Scholar]
- Harris C. A., Jenner F. A. Some aspects of the inhibition of the action of antidiuretic hormone by lithium ions in the rat kidney and bladder of the toad Bufo marinus. Br J Pharmacol. 1972 Feb;44(2):223–232. [PMC free article] [PubMed] [Google Scholar]
- RADOMSKI J. L., FUYAT H. N., NELSON A. A., SMITH P. K. The toxic effects, excretion and distribution of lithium chloride. J Pharmacol Exp Ther. 1950 Dec;100(41):429–444. [PubMed] [Google Scholar]
- RELMAN A. S., LEVINSKY N. G. Kidney disease: acquired tubular disorders (with special reference to disturbances of concentration and dilution and of acid-base regulation). Annu Rev Med. 1961;12:93–110. doi: 10.1146/annurev.me.12.020161.000521. [DOI] [PubMed] [Google Scholar]
- SCHOU M. Lithium studies. 1. Toxicity. Acta Pharmacol Toxicol (Copenh) 1958;15(1):70–84. doi: 10.1111/j.1600-0773.1958.tb00287.x. [DOI] [PubMed] [Google Scholar]
- Schou M., Amdisen A., Trap-Jensen J. Lithium poisoning. Am J Psychiatry. 1968 Oct;125(4):520–527. doi: 10.1176/ajp.125.4.520. [DOI] [PubMed] [Google Scholar]
- Schou M., Baastrup P. C. Lithium treatment of manic-depressive disorder. Dosage and control. JAMA. 1967 Aug 28;201(9):696–698. [PubMed] [Google Scholar]
- Schou M. Lithium in psychiatric therapy and prophylaxis. J Psychiatr Res. 1968 Jun;6(1):67–95. doi: 10.1016/0022-3956(68)90047-2. [DOI] [PubMed] [Google Scholar]
- Singer I., Rotenberg D., Puschett J. B. Lithium-induced nephrogenic diabetes insipidus: in vivo and in vitro studies. J Clin Invest. 1972 May;51(5):1081–1091. doi: 10.1172/JCI106900. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Statius van Eps L. W., Pinedo-Veels C., de Vries G. H., de Koning J. Nature of concentrating defect in sickle-cell nephropathy. Microradioangiographic studies. Lancet. 1970 Feb 28;1(7644):450–452. doi: 10.1016/s0140-6736(70)90836-6. [DOI] [PubMed] [Google Scholar]
- TALBOTT J. H. Use of lithium salts as a substitute for sodium chloride. Arch Intern Med (Chic) 1950 Jan;85(1):1–10. doi: 10.1001/archinte.1950.00230070023001. [DOI] [PubMed] [Google Scholar]