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. 1976 Oct;29(10):865–872. doi: 10.1136/jcp.29.10.865

Measles inclusion-body encephalitis in a child with treated acute lymphoblastic leukaemia.

H C Drysdale, L F Jones, D R Oppenheimer, A H Tomlinson
PMCID: PMC476203  PMID: 789401

Abstract

A child with acute lymphoblastic leukaemia, being treated in the UKALL II Trial, had while in remission an attack of measles and made a normal recovery. Four months later she developed an acute encephalopathy and died within two weeks. The brain showed mild inflammatory features and widespread inclusion bodies in neurones and glial cells. Immunofluorescence proved an infection with measles virus. Similar cases have been called SSPE; reasons are given for preferring the term "measles inclusion-body encephalitis".

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Breitfeld V., Hashida Y., Sherman F. E., Odagiri K., Yunis E. J. Fatal measles infection in children with leukemia. Lab Invest. 1973 Mar;28(3):279–291. [PubMed] [Google Scholar]
  2. Font R. L., Jenis E. H., Tuck K. D. Measles maculopathy associated with subacute sclerosing panencephalitis. Immunofluorescent and immuno-ultrastructural studies. Arch Pathol. 1973 Sep;96(3):168–174. [PubMed] [Google Scholar]
  3. GIBBONS J. L., MILLER H. G., STANTON J. B. Para-infectious encephalomyelitis and related syndromes; a critical review of the neurological complications of certain specific fevers. Q J Med. 1956 Oct;25(100):427–505. [PubMed] [Google Scholar]
  4. Hammon W. M., Ho M. Viral encephalitis. Dis Mon. 1973 Mar;:1–47. doi: 10.1016/s0011-5029(73)80010-0. [DOI] [PubMed] [Google Scholar]
  5. Hendin B., DeVivo D. C., Torack R., Lell M. E., Ragab A. H., Vietti T. J. Proceedings: Parenchymatous degeneration of the central nervous system in childhood leukemia. Cancer. 1974 Feb;33(2):468–482. doi: 10.1002/1097-0142(197402)33:2<468::aid-cncr2820330223>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  6. Kay H. E., Knapton P. J., O'Sullivan J. P., Wells D. G., Harris R. F., Innes E. M., Stuart J., Schwartz F. C., Thompson E. N. Encephalopathy in acute leukaemia associated with methotrexate therapy. Arch Dis Child. 1972 Jun;47(253):344–354. doi: 10.1136/adc.47.253.344. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Levine A. S., Graw R. G., Jr, Young R. C. Management of infections in patients with leukemia and lymphoma: current concepts and experimental approaches. Semin Hematol. 1972 Apr;9(2):141–179. [PubMed] [Google Scholar]
  8. Linnemann C. C., Jr, Shea L., Partin J. C., Schubert W. K., Schiff G. M. Reye's syndrome: epidemiologic and viral studies, 1963-1974. Am J Epidemiol. 1975 Jun;101(6):517–526. doi: 10.1093/oxfordjournals.aje.a112123. [DOI] [PubMed] [Google Scholar]
  9. Lyon G. Action des immuno-suppresseurs sur une encéphalite virale (rougeole): inhibition de la réaction inflammatoire. C R Acad Sci Hebd Seances Acad Sci D. 1972 Mar 20;274(12):1878–1879. [PubMed] [Google Scholar]
  10. MITUS A., ENDERS J. F., CRAIG J. M., HOLLOWAY A. Persistence of measles virus and depression of antibody formation in patients with giant-cell pneumonia after measles. N Engl J Med. 1959 Oct 29;261:882–889. doi: 10.1056/NEJM195910292611802. [DOI] [PubMed] [Google Scholar]
  11. Meadow S. R., Weller R. O., Archibald R. W. Fatal systemic measles in a child receiving cyclophosphamide for nephrotic syndrome. Lancet. 1969 Oct 25;2(7626):876–878. doi: 10.1016/s0140-6736(69)92330-7. [DOI] [PubMed] [Google Scholar]
  12. Pitner S. E., Johnson W. W. Chronic subdural hematoma in childhood acute leukemia. Cancer. 1973 Jul;32(1):185–190. doi: 10.1002/1097-0142(197307)32:1<185::aid-cncr2820320128>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  13. Price R. A., Jamieson P. A. The central nervous system in childhood leukemia. II. Subacute leukoencephalopathy. Cancer. 1975 Feb;35(2):306–318. doi: 10.1002/1097-0142(197502)35:2<306::aid-cncr2820350203>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  14. Rubinstein L. J., Herman M. M., Long T. F., Wilbur J. R. Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymphoma. Cancer. 1975 Feb;35(2):291–305. doi: 10.1002/1097-0142(197502)35:2<291::aid-cncr2820350202>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  15. Simone J. V., Holland E., Johnson W. Fatalities during remission of childhood leukemia. Blood. 1972 Jun;39(6):759–770. [PubMed] [Google Scholar]
  16. Sluga E., Budka H., Jellinger K., Pichler E. SSPE-like inclusion body disorder in treated childhood leukemia. Acta Neuropathol Suppl. 1975;Suppl 6:267–272. doi: 10.1007/978-3-662-08456-4_47. [DOI] [PubMed] [Google Scholar]
  17. Weiss H. D., Walker M. D., Wiernik P. H. Neurotoxicity of commonly used antineoplastic agents (second of two parts). N Engl J Med. 1974 Jul 18;291(3):127–133. doi: 10.1056/NEJM197407182910305. [DOI] [PubMed] [Google Scholar]
  18. ter Meulen V., Katz M., Müller D. Subacute sclerosing panencephalitis: a review. Curr Top Microbiol Immunol. 1972;57:1–38. doi: 10.1007/978-3-642-65297-4_1. [DOI] [PubMed] [Google Scholar]

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