Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1970 Oct;23(7):569–571. doi: 10.1136/jcp.23.7.569

Studies on the 57Co vitamin B12 plasma level absorption test

B K Armstrong 1, H J Woodliff 1
PMCID: PMC476837  PMID: 5483384

Abstract

Results of the 57Co vitamin B12 plasma level absorption test are described in 163 patients. The use of intramuscular carbachol with the test and the presence or absence of current vitamin B12 therapy did not affect the test results. Injection of 1,000 μg of unlabelled vitamin B12 during the test augmented plasma levels in patients with normal absorption but tests without this injection gave satisfactory differentiation between the normal and malabsorption ranges. Results from patients having had a gastrectomy, ileal resection, or a past history of adult coeliac disease are also described. Amongst patients with presumed Addisonian pernicious anaemia, two with unresolved equivocal results and three with falsely normal results were found. The significance of these is discussed.

Full text

PDF
570

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong B. K., Woodliff H. J. Vitamin B 12 absorption studies--the effect of carbachol and gastrin on the 57-Co-labelled vitamin B 12 plasma level absorption tests in patients with pernicious anaemia. Med J Aust. 1967 Apr 22;1(16):819–820. [PubMed] [Google Scholar]
  2. Armstrong B. K., Woodliff H. J. Vitamin B12 absorption studies: comparison of 57CO vitamin B12 plasma levels with and without parenteral vitamin B12. Med J Aust. 1969 Oct 4;2(14):692–693. doi: 10.5694/j.1326-5377.1969.tb107347.x. [DOI] [PubMed] [Google Scholar]
  3. BOOTH C. C., MOLLIN D. L. Plasma, tissue and urinary radioactivity after oral administration of 56Co-labelled vitamin B12. Br J Haematol. 1956 Jul;2(3):223–236. doi: 10.1111/j.1365-2141.1956.tb06695.x. [DOI] [PubMed] [Google Scholar]
  4. Coupland W. W. Plasma radioactivity after radioactive vitamin B12 given orally. Med J Aust. 1966 Jun 11;1(24):1020–1023. doi: 10.5694/j.1326-5377.1966.tb73202.x. [DOI] [PubMed] [Google Scholar]
  5. Forshaw J., Harwood L. Measurement of intestinal absorption of 57-Co vitamin B-12 by serum counting. J Clin Pathol. 1966 Nov;19(6):606–609. doi: 10.1136/jcp.19.6.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GOLDBERG S. R., TRIVEDI B. K., OLINER L. Radioactive vitamin B12 studies; experience with the urinary excretion test and the measurement of absorbed plasma radioactivity. J Lab Clin Med. 1957 Apr;49(4):583–589. [PubMed] [Google Scholar]
  7. KRISTENSEN H. P., HALD T. Measurement of plasma radioactivity following oral administration of 57Co-labelled B12. A simple diagnostic test. Dan Med Bull. 1962 Oct;9:167–170. [PubMed] [Google Scholar]
  8. MCCURDY P. R. THE DETECTION OF INTESTINAL ABSORPTION OF CO57 TAGGED VITAMIN B12 BY SERUM COUNTING. Ann Intern Med. 1965 Jan;62:97–102. doi: 10.7326/0003-4819-62-1-97. [DOI] [PubMed] [Google Scholar]
  9. McIntyre P. A., Wagner H. N., Jr Comparison of the urinary excretion and 8 hour plasma tests for vitamin B12 absorption. J Lab Clin Med. 1966 Dec;68(6):966–971. [PubMed] [Google Scholar]
  10. NELP W. B., McAFEE J. G., WAGNER H. N., Jr Single measurement of plasma radioactive vitamin B12 as a test for pernicious anemia. J Lab Clin Med. 1963 Jan;61:158–165. [PubMed] [Google Scholar]
  11. Woodliff H. J., Armstrong B. K. Vitamin B12 absorption studies: comparison of 57Co vitamin B12 plasma levels, urinary excretion and faecal excretion. Med J Aust. 1966 Jun 11;1(24):1023–1025. doi: 10.5694/j.1326-5377.1966.tb73203.x. [DOI] [PubMed] [Google Scholar]
  12. Workman J. B., Rusche E. Cobalt-57 labeled vitamin B-12 plasma levels for the differential diagnosis of macrocytic anemias. J Nucl Med. 1966 Aug;7(8):583–588. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES