Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1972 Aug;25(8):726–729. doi: 10.1136/jcp.25.8.726

The measurement of serum thyroxine in children

Jennifer Ryness 1,2
PMCID: PMC477488  PMID: 4627748

Abstract

A competitive protein-binding method was used to determine serum thyroxine concentration throughout childhood, adolescence, and in young adults. The values showed a gradual decrease as the child became older and reached adult levels by the time of adolescence. The range (mean ± 2 SD μg/100 ml) for cord serum was 8·8-14·8; for 4 weeks to 11 years, 6·5-13·9; for 11 to 17 years, 5·4-12·2, and for young adults 6·0-11·2.

Full text

PDF
728

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arango G., Mayberry W. E., Hockert T. J., Elveback L. R. Total and free human serum thyroxine in normal and abnormal thyroid states. Mayo Clin Proc. 1968 Jul;43(7):503–516. [PubMed] [Google Scholar]
  2. EKINS R. P. The estimation of thyroxine in human plasma by an electrophoretic technique. Clin Chim Acta. 1960 Jul;5:453–459. doi: 10.1016/0009-8981(60)90051-6. [DOI] [PubMed] [Google Scholar]
  3. Edwards R. W., McCracken J. H. Glove box system for micro-determination of protein-bound iodine in children's blood. J Clin Pathol. 1967 May;20(3):302–303. doi: 10.1136/jcp.20.3.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FISHER D. A., ODDIE T. H. NEONATAL THYROIDAL HYPERACTIVITY. RESPONSE TO COOLING. Am J Dis Child. 1964 Jun;107:574–581. doi: 10.1001/archpedi.1964.02080060576004. [DOI] [PubMed] [Google Scholar]
  5. Fisher D. A., Odell W. D., Hobel C. J., Garza R. Thyroid function in the term fetus. Pediatrics. 1969 Oct;44(4):526–535. [PubMed] [Google Scholar]
  6. Howorth P. J., Maclagan N. F. Clinical application of serum-total-thyroxine estimation, resin uptake, and free-thyroxine index. Lancet. 1969 Feb 1;1(7588):224–228. doi: 10.1016/s0140-6736(69)91240-9. [DOI] [PubMed] [Google Scholar]
  7. Maclagan N. F., Howorth P. J. Thyroid function studies using resin uptake of radioactive thyronines from serum and total thyroxine assay; the free thyroxine index. Clin Sci. 1969 Aug;37(1):45–60. [PubMed] [Google Scholar]
  8. Malkasian G. D., Mayberry W. E. Serum total and free thyroxine and thyrotropin in normal and pregnant women, neonates, and women receiving progestogens. Am J Obstet Gynecol. 1970 Dec 15;108(8):1234–1238. doi: 10.1016/0002-9378(70)90098-0. [DOI] [PubMed] [Google Scholar]
  9. Murphy B. E., Pattee C. J., Gold A. Clinical evaluation of a new method for the determination of serum thyroxine. J Clin Endocrinol Metab. 1966 Mar;26(3):247–256. doi: 10.1210/jcem-26-3-247. [DOI] [PubMed] [Google Scholar]
  10. Murray I. P., Joasoo A., Parkin J. In-vitro thyroid tests in children. Med J Aust. 1971 Jan 9;1(2):77–79. doi: 10.5694/j.1326-5377.1971.tb87443.x. [DOI] [PubMed] [Google Scholar]
  11. Nakajima H., Kuramochi M., Horiguchi T., Kubo S. A new and simple method for the determination of thyroxine in serum. J Clin Endocrinol Metab. 1966 Jan;26(1):99–103. doi: 10.1210/jcem-26-1-99. [DOI] [PubMed] [Google Scholar]
  12. Nusynowitz M. L., Waliszewski J. Simplification of determination of serum thyroxine iodine by competitive binding analysis. Am J Roentgenol Radium Ther Nucl Med. 1969 Aug;106(4):791–793. doi: 10.2214/ajr.106.4.791. [DOI] [PubMed] [Google Scholar]
  13. Robin N. I., Refetoff S., Fang V., Selenkow H. A. Parameters of thyroid function in maternal and cord serum at term pregnancy. J Clin Endocrinol Metab. 1969 Sep;29(9):1276–1280. doi: 10.1210/jcem-29-9-1276. [DOI] [PubMed] [Google Scholar]
  14. Siersbaek-Nielsen K., Hansen J. M. Thyroid function and plasma tyrosine in the neonatal period. Acta Paediatr Scand. 1967 Mar;56(2):141–150. doi: 10.1111/j.1651-2227.1967.tb15357.x. [DOI] [PubMed] [Google Scholar]
  15. Sterling K., Brenner M. A. Free thyroxine in human serum: simplified measurement with the aid of magnesium precipitation. J Clin Invest. 1966 Jan;45(1):153–163. doi: 10.1172/JCI105320. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES