Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1972 Nov;25(11):979–983. doi: 10.1136/jcp.25.11.979

The in-vitro activity of tobramycin compared with that of other aminoglycosides

Pamela M Waterworth 1
PMCID: PMC477579  PMID: 4648543

Abstract

The influence of medium composition, pH, serum, and magnesium on the action of tobramycin is compared to that on the action of gentamicin. The minimum inhibitory concentration of tobramycin, gentamicin, kanamycin, and streptomycin was determined for 472 strains including 19 species: tobramycin was found to be the most active against Ps. aeruginosa and kanamycin against Providence, but gentamicin was usually the most active against all other species. Ps. aeruginosa passaged on medium containing either gentamicin or tobramycin showed increased resistance to both. Sensitive strains of this species were shown to contain a small minority of cells resistant to these antibiotics, the presence of which is believed to account for the marked bactericidal synergy which was demonstrated between tobramycin and carbenicillin.

Full text

PDF
982

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Darrell J. H., Waterworth P. M. Dosage of gentamicin for pseudomonas infections. Br Med J. 1967 May 27;2(5551):535–537. doi: 10.1136/bmj.2.5551.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Garrod L. P., Waterworth P. M. Effect of medium composition on the apparent sensitivity of Pseudomonas aeruginosa to gentamicin. J Clin Pathol. 1969 Sep;22(5):534–538. doi: 10.1136/jcp.22.5.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Higgins C. E., Kastner R. E. Nebramycin, a new broad-spectrum antibiotic complex. II. Description of Streptomyces tenebrarius. Antimicrob Agents Chemother (Bethesda) 1967;7:324–331. [PubMed] [Google Scholar]
  4. Meyer R. D., Young L. S., Armstrong D. Tobramycin (nebramycin factor 6): in vitro activity against Pseudomonas aeruginosa. Appl Microbiol. 1971 Dec;22(6):1147–1151. doi: 10.1128/am.22.6.1147-1151.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Preston D. A., Wick W. E. Preclinical assessment of the antibacterial activity of nebramycin factor 6. Antimicrob Agents Chemother (Bethesda) 1970;10:322–327. doi: 10.1128/AAC.10.2.322. [DOI] [PubMed] [Google Scholar]
  6. Sonne M., Jawetz E. Combined action of carbenicillin and gentamicin on Pseudomonas aeruginosa in vitro. Appl Microbiol. 1969 Jun;17(6):893–896. doi: 10.1128/am.17.6.893-896.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Stark W. M., Hoehn M. M., Knox N. G. Nebramycin, a new broad-spectrum antibiotic complex. I. Detection and biosynthesis. Antimicrob Agents Chemother (Bethesda) 1967;7:314–323. [PubMed] [Google Scholar]
  8. Thompson R. Q., Presti E. A. Nebramycin, a new broad-spectrum antibiotic complex. 3. Isolation and chemical-physical properties. Antimicrob Agents Chemother (Bethesda) 1967;7:332–340. [PubMed] [Google Scholar]
  9. Traub W. H., Raymond E. A. Evaluation of the in vitro activity of tobramycin as compared with that of gentamicin sulfate. Appl Microbiol. 1972 Jan;23(1):4–7. doi: 10.1128/am.23.1.4-7.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Wick W. E., Welles J. S. Nebramycin, a new broad-spectrum antibiotic complex. IV. In vitro and in vivo laboratory evaluation. Antimicrob Agents Chemother (Bethesda) 1967;7:341–348. doi: 10.1128/AAC.7.3.341. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES