Abstract
A trial of prophylactic replacement therapy in low dosage once a week is described in two patients with classical haemophilia and one patient with Christmas disease, using concentrates of factor VIII and factor IX respectively. The clinical effectiveness and complications of the therapy are assessed and discussed. It was concluded that the patient suffering from Christmas disease showed both objective and subjective improvement while on prophylaxis and merited further study. Neither of the patients with haemophilia showed objective evidence of improvement, but both stated that they felt fitter and more able to lead a normal life while on the trial.
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Selected References
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- Ahrons S., Glavind-Kristensen S., Drachmann O., Kissmeyer-Nielsen F. Severe reactions after cryoprecipitated human factor VIII. Vox Sang. 1970 Feb;18(2):182–184. doi: 10.1111/j.1423-0410.1970.tb01445.x. [DOI] [PubMed] [Google Scholar]
- Das P. C., Hopkins R., Cash J. D., Cumming R. A. Rapid identification of hepatitis associated antigen and antibody by counter-immunoelectroosmophoresis. Br J Haematol. 1971 Dec;21(6):673–676. doi: 10.1111/j.1365-2141.1971.tb02729.x. [DOI] [PubMed] [Google Scholar]
- Dike G. W., Bidwell E., Rizza C. R. The preparation and clinical use of a new concentrate containing factor IX, prothrombin and factor X and of a separate concentrate containing factor VII. Br J Haematol. 1972 Apr;22(4):469–490. doi: 10.1111/j.1365-2141.1972.tb05693.x. [DOI] [PubMed] [Google Scholar]
- HARDISTY R. M., MACPHERSON J. C. A one-stage factor VIII (antihaemophilic globulin) assay and its use on venous and capillary plasma. Thromb Diath Haemorrh. 1962 May 15;7:215–228. [PubMed] [Google Scholar]
- Haanen C., McShine R. L., Kunst A. Preparation and clinical use of factor IX concentrate PPSB according to Soulier. Vox Sang. 1969 Apr;16(4):398–411. [PubMed] [Google Scholar]
- Hirschman R. J., Itscoitz S. B., Shulman N. R. Prophylactic treatment of factor VIII deficiency. Blood. 1970 Feb;35(2):189–194. [PubMed] [Google Scholar]
- Ikkala E., Simonen O. Factor 8 inhibitors and the use of blood products in patients with haemophilia A. Scand J Haematol. 1971;8(1):16–20. doi: 10.1111/j.1600-0609.1971.tb02666.x. [DOI] [PubMed] [Google Scholar]
- POOL J. G., GERSHGOLD E. J., PAPPENHAGEN A. R. HIGH-POTENCY ANTIHAEMOPHILIC FACTOR CONCENTRATE PREPARED FROM CRYOGLOBULIN PRECIPITATE. Nature. 1964 Jul 18;203:312–312. doi: 10.1038/203312a0. [DOI] [PubMed] [Google Scholar]
- Prince A. M., Burke K. Serum hepatitis antigen (SH): rapid detection by high voltage immunoelectroosmophoresis. Science. 1970 Aug 7;169(3945):593–595. doi: 10.1126/science.169.3945.593. [DOI] [PubMed] [Google Scholar]
- Roberts H. R., Scales M. B., Madison J. T., Webster W. P., Penick G. D. A clinical and experimental study of acquired inhibitors to factor 8. Blood. 1965 Dec;26(6):805–818. [PubMed] [Google Scholar]
- Robinson P. M., Tittley P., Smiley R. K. Prophylactic therapy in classical hemophilia: a preliminary report. Can Med Assoc J. 1967 Sep 9;97(11):559–561. [PMC free article] [PubMed] [Google Scholar]
- Shanbrom E., Thelin G. M. Experimental prophylaxis of severe hemophilia with a factor VIII concentrate. JAMA. 1969 Jun 9;208(10):1853–1856. [PubMed] [Google Scholar]
- Van Creveld S., Buchner R. Dental extractions and the use of Christmas factor concentrate in cases of haemophilia B. Vox Sang. 1970 May;18(5):441–449. doi: 10.1111/j.1423-0410.1970.tb01482.x. [DOI] [PubMed] [Google Scholar]
- Van Creveld S. Prophylaxis of joint hemorrhages in hemophilia. Acta Haematol. 1971;45(2):120–127. doi: 10.1159/000208615. [DOI] [PubMed] [Google Scholar]