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. 1974 Nov;28(4):226–232. doi: 10.1136/jech.28.4.226

Distribution of Paget's disease in England, Wales and Scotland and a possible relationship with vitamin D deficiency in childhood

D J P Barker 1, M J Gardner 1
PMCID: PMC478867  PMID: 4455340

Abstract

Within England, Wales, and Scotland there are regional variations in hospital discharge rates for Paget's disease (osteitis deformans). Successive cohorts born after the 1880s show a progressive fall in mortality from Paget's disease. Because of the epidemiological similarity between the disease and rickets it is suggested that vitamin D deficiency in childhood may be a predisposing influence.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BROWN W. M., DOLL R., HEASMAN M. A., SISSONS H. A. Geographical distribution of primary tumours of bone in England and Wales. Br J Prev Soc Med. 1961 Oct;15:167–170. doi: 10.1136/jech.15.4.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CHILDS B., CANTOLINO S., DYKE M. K. Observations on sex differences in human biology. Bull Johns Hopkins Hosp. 1962 Mar;110:134–144. [PubMed] [Google Scholar]
  3. COLLINS D. H. Paget's disease of bone; incidence and subclinical forms. Lancet. 1956 Jul 14;271(6933):51–57. doi: 10.1016/s0140-6736(56)90422-6. [DOI] [PubMed] [Google Scholar]
  4. Eddy T. P. Deaths from domestic falls and fractures. Br J Prev Soc Med. 1972 Aug;26(3):173–179. doi: 10.1136/jech.26.3.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Francis M. J., Smith R. Evidence of a generalised connective-tissue defect in Paget's disease of bone. Lancet. 1974 May 4;1(7862):841–841. doi: 10.1016/s0140-6736(74)90487-5. [DOI] [PubMed] [Google Scholar]
  6. MACKENZIE A., COURT BROWN W. M., DOLL R., SISSONS H. A. Mortality from primary tumours of bone in England and Wales. Br Med J. 1961 Jun 24;1(5242):1782–1790. doi: 10.1136/bmj.1.5242.1782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Nordin B. E. Clinical significance and pathogenesis of osteoporosis. Br Med J. 1971 Mar 13;1(5749):571–576. doi: 10.1136/bmj.1.5749.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. PRICE C. H. The incidence of osteogenic sarcoma in South-West England and its relationship to Paget's disease of bone. J Bone Joint Surg Br. 1962 May;44-B:366–376. doi: 10.1302/0301-620X.44B2.366. [DOI] [PubMed] [Google Scholar]
  9. ROSENKRANTZ J. A., WOLF J., KAICHER J. J. Paget's disease (osteitis deformans); review of one hundred eleven cases. AMA Arch Intern Med. 1952 Nov;90(5):610–633. doi: 10.1001/archinte.1952.00240110036005. [DOI] [PubMed] [Google Scholar]

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