Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1958 May;11(3):195–204. doi: 10.1136/jcp.11.3.195

THE NATURE, DETERMINATION, AND CLINICAL IMPORTANCE OF BLOOD IODINE: A REVIEW

J D Acland 1,2
PMCID: PMC479749  PMID: 13539221

Full text

PDF
199

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACLAND J. D. A possible source of artifacts in the chromatography of tissue extracts containing inorganic iodide. Nature. 1952 Jul 5;170(4314):32–33. doi: 10.1038/170032a0. [DOI] [PubMed] [Google Scholar]
  2. BARKER S. B., HUMPHREY M. J., SOLEY M. H. The clinical determination of protein-bound iodine. J Clin Invest. 1951 Jan;30(1):55–62. doi: 10.1172/JCI102416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BEIERWALTES W. H. The value of radioactive iodine uptake and protein-bound iodine estimations in the diagnosis of thyrotoxicosis. Ann Intern Med. 1956 Jan;44(1):40–51. doi: 10.7326/0003-4819-44-1-40. [DOI] [PubMed] [Google Scholar]
  4. BLACKBURN C. M., POWER M. H. Diagnostic accuracy of serum protein-bound iodine determination in thyroid disease. J Clin Endocrinol Metab. 1955 Nov;15(11):1379–1392. doi: 10.1210/jcem-15-11-1379. [DOI] [PubMed] [Google Scholar]
  5. BLOMFIELD G. W., JONES J. C., MACGREGOR A. G., MILLER H., WAYNE E. J. Treatment of thyrotoxicosis with radioactive iodine. Br Med J. 1951 Aug 18;2(4728):373–381. doi: 10.1136/bmj.2.4728.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BLOM P. S., TERPSTRA J. High PBI131 concentration in blood of patients with myxedema; preliminary report. J Clin Endocrinol Metab. 1953 Aug;13(8):989–993. doi: 10.1210/jcem-13-8-989. [DOI] [PubMed] [Google Scholar]
  7. BONATI B., SALVI A., RANCATI G. B., PEDRELLI M. Psicosi e tiroide. - comportamento della jodoprotidemia e colesterolemia nei malati di mente e loro modificazioni dopi elettroshock, coma insulinico, leucotomia prefrontale ed ipnoterapia. Folia Endocrinol Mens Incretologia Incretoterapia. 1955 Jun;8(3):321–340. [PubMed] [Google Scholar]
  8. BOWDEN C. H., MACLAGAN N. F., WILKINSON J. H. The application of the ceric sulphate-arsenious acid reaction to the detection of thyroxine and related substances. Biochem J. 1955 Jan;59(1):93–97. doi: 10.1042/bj0590093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. BREANT P. Iodémie protéique et état fonctionnel de la thyroïde. Sem Hop. 1955 Oct 14;31(60):3160–3163. [PubMed] [Google Scholar]
  10. BROWN H., REINGOLD A. M., SAMSON M. The determination of protein-bound iodine by dry ashing. J Clin Endocrinol Metab. 1953 Apr;13(4):444–450. doi: 10.1210/jcem-13-4-444. [DOI] [PubMed] [Google Scholar]
  11. CARAWAY W. T. Calculation of protein-bound iodine from kinetic data. J Clin Endocrinol Metab. 1952 May;12(9):1215–1219. doi: 10.1210/jcem-12-9-1215. [DOI] [PubMed] [Google Scholar]
  12. CATTANEO C., DE SIMONI G., FANTOLI U. Il comportamento dello jodio sierico precipitabile prima e dopo intervento chirurgico su soggetti affetti da tubercolosi polmonare. Prog Med (Napoli) 1955 Aug 31;11(16):481–484. [PubMed] [Google Scholar]
  13. CHAMOVITZ D. L., SLEISENGER M. H., FREEDBERG A. S. Thyrotoxicosis factitia; measurement of the thyroid gland I131 uptake and serum protein-bound I131. Am J Med. 1951 Aug;11(2):255–260. doi: 10.1016/0002-9343(51)90160-x. [DOI] [PubMed] [Google Scholar]
  14. CRISPELL K. R., COLEMAN J. A study of the relative binding capacity of plasma proteins, intact human red cells, and human red cell stroma for radioactive I-131 labeled L-thyroxine. J Clin Invest. 1956 May;35(5):475–480. doi: 10.1172/JCI103299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. CRISPELL K. R., KAHANA S., HYER H. The effect of plasma on the in vitro uptake or binding by human red cells of radioactive I-131 labeled L-thyroxine and L-triiodothyronine. J Clin Invest. 1956 Jan;35(1):121–124. doi: 10.1172/JCI103246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. DANIELSON R. E., REALS W. J., TOWNSEND F. M. Determination of protein-bound iodine by the Leffler method. U S Armed Forces Med J. 1956 Sep;7(9):1293–1301. [PubMed] [Google Scholar]
  17. DE PASCALE A. La iodoprotidemia nell'infanzia. Lattante. 1956 Feb;27(2):84–91. [PubMed] [Google Scholar]
  18. DEISS W. P., ALBRIGHT E. C., LARSON F. C. Comparison of in vitro serum protein binding of thyroxin and triiodothyronine. Proc Soc Exp Biol Med. 1953 Nov;84(2):513–516. doi: 10.3181/00379727-84-20696. [DOI] [PubMed] [Google Scholar]
  19. DINGLEDINE W. S., PITTRIVERS R., STANBURY J. B. Nature and transport of the iodinated substances of the blood of normal subjects and of patients with thyroid disease. J Clin Endocrinol Metab. 1955 Jun;15(6):724–731. doi: 10.1210/jcem-15-6-724. [DOI] [PubMed] [Google Scholar]
  20. DOBYNS B. M., HIRSCH E. Z. Iodinated compounds in the lymphatic pathways leading from the thyroid. J Clin Endocrinol Metab. 1956 Jan;16(1):153–155. doi: 10.1210/jcem-16-1-153. [DOI] [PubMed] [Google Scholar]
  21. DONOWSKI T. S., HUFF S. J., TARAIL R., WIRTH P., PETERS J. H., MATEER F. M., GARVER K. Serum protein-bound iodine during ingestion of desiccated thyroid. J Clin Endocrinol Metab. 1952 Dec;12(12):1572–1577. doi: 10.1210/jcem-12-12-1572. [DOI] [PubMed] [Google Scholar]
  22. DURHAM J. R., COOKE R. E., LANCASTER J. W., MAN E. B. Serum butanol-extractable iodine values of children under ten years of age. AMA Am J Dis Child. 1954 Apr;87(4):468–474. doi: 10.1001/archpedi.1954.02050090456006. [DOI] [PubMed] [Google Scholar]
  23. ENGSTROM W. W., MARKARDT B. The effects of serious illness and surgical stress on the circulating thyroid hormone. J Clin Endocrinol Metab. 1955 Aug;15(8):953–963. doi: 10.1210/jcem-15-8-953. [DOI] [PubMed] [Google Scholar]
  24. FELLER D. D., CHAIKOFF I. L. The changes induced in iodine metabolism of the rat by internal radiation of its thyroid with I131. Endocrinology. 1949 Nov;45(5):464–479. doi: 10.1210/endo-45-5-464. [DOI] [PubMed] [Google Scholar]
  25. FISCHL J. Determination of protein-bound iodine in micro-amounts of serum or plasma. Clin Chim Acta. 1956 Sep-Oct;1(5):462–469. doi: 10.1016/0009-8981(56)90019-5. [DOI] [PubMed] [Google Scholar]
  26. FRASER R. Clinical tests of thyroid function. Lancet. 1956 Sep 22;271(6943):581–586. doi: 10.1016/s0140-6736(56)92289-9. [DOI] [PubMed] [Google Scholar]
  27. FRIIS T. Protein-bound iodine (PBI)-investigation into Barker's distillation method. Scand J Clin Lab Invest. 1955;7(4):336–346. doi: 10.3109/00365515509134674. [DOI] [PubMed] [Google Scholar]
  28. GORDON A. H., GROSS J., O'CONNOR D., PITT-RIVERS R. Nature of the circulating thyroid hormone-plasma protein complex. Nature. 1952 Jan 5;169(4288):19–20. doi: 10.1038/169019a0. [DOI] [PubMed] [Google Scholar]
  29. GOTTSCHALK C. W., RIGGS D. S. Protein-bound iodine in the serum of soldiers and of Eskimos in the Artic. J Clin Endocrinol Metab. 1952 Feb;12(2):235–243. doi: 10.1210/jcem-12-2-235. [DOI] [PubMed] [Google Scholar]
  30. GROSS J., LEBLOND C. P. The presence of free iodinated compounds in the thyroid and their passage into the circulation. Endocrinology. 1951 Jun;48(6):714–725. doi: 10.1210/endo-48-6-714. [DOI] [PubMed] [Google Scholar]
  31. GROSS J., PITT-RIVERS R. The identification of 3:5:3'-L-triiodothyronine in human plasma. Lancet. 1952 Mar 1;1(6705):439–441. doi: 10.1016/s0140-6736(52)91952-1. [DOI] [PubMed] [Google Scholar]
  32. HILL S. R., Jr, REISS R. S., FORSHAM P. H., THORN G. W. The effect of adrenocorticotropin and cortisone on thyroid function; thyroid-adrenocortical interrelationships. J Clin Endocrinol Metab. 1950 Nov;10(11):1375–1400. doi: 10.1210/jcem-10-11-1375. [DOI] [PubMed] [Google Scholar]
  33. Harington C. R., Randall S. S. Observations on the iodine-containing compounds of the thyroid gland. Isolation of dl-3:5-di-iodotyrosine. Biochem J. 1929;23(3):373–383. doi: 10.1042/bj0230373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Heinemann M., Johnson C. E., Man E. B. SERUM PRECIPITABLE IODINE CONCENTRATIONS DURING PREGNANCY. J Clin Invest. 1948 Jan;27(1):91–97. doi: 10.1172/JCI101928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. INGBAR S. H., FREINKEL N., HOEPRICH P. D., ATHENS J. W. The concentration and significance of the butanol-extractable I131 of serum in patients with diverse states of thyroidal function. J Clin Invest. 1954 Mar;33(3):388–399. doi: 10.1172/JCI102911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. KYDD D. M., MAN E. B. Precipitable iodine of serum (SPI) in disorders of the liver. J Clin Invest. 1951 Aug;30(8):874–878. doi: 10.1172/JCI102503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. LAMBERG B. A., WAHLBERG P., FORSIUS P. I. The serum protein-bound iodine as a diagnostic aid. Acta Med Scand. 1956 May 3;154(3):201–210. doi: 10.1111/j.0954-6820.1956.tb14314.x. [DOI] [PubMed] [Google Scholar]
  38. LARSON F. C., DEISS W. P., ALBRIGHT E. C. Radiochromatographic identification of thyroxin in an alpha globulin fraction of serum separated by starch zone electrophoresis. J Clin Invest. 1954 Feb;33(2):230–234. doi: 10.1172/JCI102889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. LUM J., MAN E. B. Serum butanol-extractable iodines in abortions. Yale J Biol Med. 1955 Nov;28(2):105–120. [PMC free article] [PubMed] [Google Scholar]
  40. Lerman J. IODINE COMPONENTS OF THE BLOOD. CIRCULATING THYROGLOBULIN IN NORMAL PERSONS AND IN PERSONS WITH THYROID DISEASE. J Clin Invest. 1940 Jul;19(4):555–560. doi: 10.1172/JCI101158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. MAN E. B., BONDY P. K., WEEKS E. A., PETERS J. P. Normal range of serum butanol-extractable iodine of human adults. Yale J Biol Med. 1954 Nov;27(2):90–96. [PMC free article] [PubMed] [Google Scholar]
  42. MAN E. B., HEINEMANN M., JOHNSON C. E., LEARY D. C., PETERS J. P. The precipitable iodine of serum in normal pregnancy and its relation to abortions. J Clin Invest. 1951 Feb;30(2):137–150. doi: 10.1172/JCI102426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. MAN E. B., KYDD D. M., PETERS J. P. Butanol-extractable iodine of serum. J Clin Invest. 1951 May;30(5):531–538. doi: 10.1172/JCI102469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. MCCONAHEY W. M., OWEN C. A., Jr An unusual iodinated protein of the serum in Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1956 Dec;16(12):1570–1579. doi: 10.1210/jcem-16-12-1570. [DOI] [PubMed] [Google Scholar]
  45. MCGIRR E. M., HUTCHISON J. H. Radioactive-iodine studies in non-endemic goitrous cretinism. Lancet. 1953 Jun 6;1(6771):1117–1120. doi: 10.1016/s0140-6736(53)92307-1. [DOI] [PubMed] [Google Scholar]
  46. MEYER K. R., DICKENMAN R. C., WHITE E. G., ZAK B. Study of inhibition of the ceric-arsenite reaction and application to analysis of protein-bound iodine. Am J Clin Pathol. 1955 Oct;25(10):1160–1170. doi: 10.1093/ajcp/25.10.1160. [DOI] [PubMed] [Google Scholar]
  47. MICHEL R. Thyroid. Annu Rev Physiol. 1956;18:457–482. doi: 10.1146/annurev.ph.18.030156.002325. [DOI] [PubMed] [Google Scholar]
  48. MUELLER R., BRAUSCH C. C., HIRSCH E. Z., BENUA R. S., DOBYNS B. M. Uptake of radioactive iodine in the thyroid of patients with impaired liver function. J Clin Endocrinol Metab. 1954 Nov;14(11):1287–1299. doi: 10.1210/jcem-14-11-1287. [DOI] [PubMed] [Google Scholar]
  49. Man E. B., Smirnow A. E., Gildea E. F., Peters J. P. SERUM IODINE FRACTIONS IN HYPERTHYROIDISM. J Clin Invest. 1942 Nov;21(6):773–780. doi: 10.1172/JCI101354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. O'NEAL L. W., SIMMS E. S. Determination of protein-bound iodine in plasma or serum; a simple and rapid method. Am J Clin Pathol. 1953 May;23(5):493–505. doi: 10.1093/ajcp/23.5_ts.493. [DOI] [PubMed] [Google Scholar]
  51. OWEN C. A., Jr, MCKENZIE B. F., ORVIS A. L. An artifact in thyroxine chromatography using dioxane. J Lab Clin Med. 1956 Jan;47(1):145–148. [PubMed] [Google Scholar]
  52. PETERMANN M. L., ROBBINS J., HAMILTON M. G. Sedimentation of the thyroxine-binding protein of serum in the partition cell. J Biol Chem. 1954 May;208(1):369–375. [PubMed] [Google Scholar]
  53. QUERIDO A., STANBURY J. B., KASSENAAR A. A., MEIJER J. W. The metabolism of iodotyrosines. III. Di-iodotyrosine deshalogenating activity of human thyroid tissue. J Clin Endocrinol Metab. 1956 Aug;16(8):1096–1101. doi: 10.1210/jcem-16-8-1096. [DOI] [PubMed] [Google Scholar]
  54. RALL J. E., RAWSON R. W., TATA J. R. Studies on an iodinated protein in the serum of subjects with cancer of the thyroid. J Clin Endocrinol Metab. 1956 Dec;16(12):1554–1569. doi: 10.1210/jcem-16-12-1554. [DOI] [PubMed] [Google Scholar]
  55. RIGGS D. S. Quantitative aspects of iodine metabolism in man. Pharmacol Rev. 1952 Sep;4(3):284–370. [PubMed] [Google Scholar]
  56. ROBBINS J., PETERMANN M. L., RALL J. E. Electrophoresis of the thyroxine-binding protein of serum at pH 4.5. J Biol Chem. 1955 Jan;212(1):403–410. [PubMed] [Google Scholar]
  57. ROBBINS J., PETERMANN M. L., RALL J. E. Thyroglobulin in serum after I131 therapy. II. Sedimentation in the ultracentrifuge. J Biol Chem. 1954 May;208(1):387–393. [PubMed] [Google Scholar]
  58. ROBBINS J., RALL J. E., RAWSON R. W. A new serum iodine component in patients with functional carcinoma of the thyroid. J Clin Endocrinol Metab. 1955 Nov;15(11):1315–1331. doi: 10.1210/jcem-15-11-1315. [DOI] [PubMed] [Google Scholar]
  59. ROBBINS J. Thyroglobulin in serum after I131 therapy. I. Salting out. J Biol Chem. 1954 May;208(1):377–386. [PubMed] [Google Scholar]
  60. ROCHE J., LISSITZKY S., MICHEL R. Sur la triiodothyronine, produit intermédiaire de la transformation de la diiodothyronine en thyroxine. C R Hebd Seances Acad Sci. 1952 Feb 25;234(9):997–998. [PubMed] [Google Scholar]
  61. ROCHE J., MICHEL R., MICHEL O., LISSITZKY S. Sur la déshalogénation enzymatique des iodotyrosine par le corps thyroïde et sur son rôle physiologique. Biochim Biophys Acta. 1952;9(2):161–169. doi: 10.1016/0006-3002(52)90143-1. [DOI] [PubMed] [Google Scholar]
  62. SANZ M. C., BRECHBUHLER T., GREEN I. J. The ultramicro-determination of total and protein-bound iodine. Clin Chim Acta. 1956 Nov-Dec;1(6):570–576. doi: 10.1016/0009-8981(56)90044-4. [DOI] [PubMed] [Google Scholar]
  63. SKANSE B., HEDENSKOG I. The determination of serum protein-bound iodine by alkali incineration; values in normal subjects. Scand J Clin Lab Invest. 1955;7(4):291–297. doi: 10.3109/00365515509134666. [DOI] [PubMed] [Google Scholar]
  64. SLADE C. I. Application of a simple ion exchange resin technique to determination of serum or plasma protein-bound I27 or protein bound I131. J Clin Endocrinol Metab. 1956 Aug;16(8):1122–1125. doi: 10.1210/jcem-16-8-1122. [DOI] [PubMed] [Google Scholar]
  65. STANBURY J. B., KASSENAAR A. A., MEIJER J. W., TERPSTRA J. The occurrence of mono- and di-iodotyrosine in the blood of a patient with congenital goiter. J Clin Endocrinol Metab. 1955 Oct;15(10):1216–1227. doi: 10.1210/jcem-15-10-1216. [DOI] [PubMed] [Google Scholar]
  66. STARR P., LIEBHOLD-SCHUECK R. Theory of thyroid hormone action; conclusions derived from differences in effect of sodium 1-thyroxine, sodium d-thyroxine, triiodothyronine and potassium iodide on uptake of radioactive iodine by thyroid gland of normal human subjects. AMA Arch Intern Med. 1953 Dec;92(6):880–888. doi: 10.1001/archinte.1953.00240240116008. [DOI] [PubMed] [Google Scholar]
  67. SUNDERMAN F. W., SUNDERMAN F. W., Jr The clinical significance of measurements of protein-bound iodine. Am J Clin Pathol. 1954 Aug;24(8):885–902. doi: 10.1093/ajcp/24.8.885. [DOI] [PubMed] [Google Scholar]
  68. TAUROG A., WHEAT J. D., CHAIKOFF I. L. Nature of the I131 compounds appearing in the thyroid vein after injection of iodide-I131. Endocrinology. 1956 Jan;58(1):121–131. doi: 10.1210/endo-58-1-121. [DOI] [PubMed] [Google Scholar]
  69. THOMPSON H. L., KLUGERMAN M. R., TRUEMPER J. A method for protein-bound iodine: the kinetics and the use of controls in the ashing technique. J Lab Clin Med. 1956 Jan;47(1):149–163. [PubMed] [Google Scholar]
  70. TONG W., TAUROG A., CHAIKOFF I. L. Nature of plasma iodine following destruction of the rat thyroid with I131. J Biol Chem. 1952 Mar;195(1):407–413. [PubMed] [Google Scholar]
  71. WALSER A., LUDWIG H., VON ORTELLI G. Der diagnostische Wert der Bestimmung des Plasma-Eiweiss-Jods und des Schlafgrundumsatzes. Helv Med Acta. 1954 Oct;21(4-5):413–418. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES