Abstract
The bentonite flocculation test of Bozicevich, Bunim, Freund, and Ward (1958), the latex fixation test of Singer and Plotz (1956), and the “RA-test” (a latex reagent for use as a slide test) of Hyland Laboratories have been compared with each other and with a modified Rose-Waaler test, the behaviour of which has been previously extensively investigated. In these tests sera from 2,250 patients were tested by two or more methods on 3,000 occasions. The findings of this trial are set out and the merits of the tests and reasons for disagreement among them are discussed. It is concluded that the most satisfactory means of testing rheumatoid sera is by the Rose-Waaler test and the “RA-test,” or a satisfactory modification of it, in parallel.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOZICEVICH J., BUNIM J. J., FREUND J., WARD S. B. Bentonite flocculation test for rheumatoid arthritis. Proc Soc Exp Biol Med. 1958 Jan;97(1):180–183. doi: 10.3181/00379727-97-23681. [DOI] [PubMed] [Google Scholar]
- FRANKLIN E. C., HOLMAN H. R., MULLER-EBERHARD H. J., KUNKEL H. G. An unusual protein component of high molecular weight in the serum of certain patients with rheumatoid arthritis. J Exp Med. 1957 May 1;105(5):425–438. doi: 10.1084/jem.105.5.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GREENBURY C. L. Elution of the rheumatoid-arthritis factor from red-cell agglutinates. Lancet. 1956 Sep 29;271(6944):644–646. doi: 10.1016/s0140-6736(56)92335-2. [DOI] [PubMed] [Google Scholar]
- HELLER G., JACOBSON A. S., KOLODNY M. H., KAMMERER W. H. The hemagglutination test for rheumatoid arthritis. II. The influence of human plasma fraction II (gamma globulin) on the reaction. J Immunol. 1954 Jan;72(1):66–78. [PubMed] [Google Scholar]
- LOSPALLUTO J., ZIFF M. Chromatographic studies of the rheumatoid factor. J Exp Med. 1959 Aug 1;110(2):169–186. doi: 10.1084/jem.110.2.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PLOTZ C. M., SINGER J. M. The latex fixation test. I. Application to the serologic diagnosis of rheumatoid arthritis. Am J Med. 1956 Dec;21(6):888–892. [PubMed] [Google Scholar]