Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1964 Jul;17(4):461–465. doi: 10.1136/jcp.17.4.461

Activity of ampicillin in vitro compared with other antibiotics

R Sutherland 1, G N Rolinson 1
PMCID: PMC480790  PMID: 14195635

Abstract

Comparative tests in vitro for antibacterial activity were carried out with ampicillin, tetracycline, and chloramphenicol using 673 clinical isolates of Gram-negative bacilli and Streptococcus faecalis. Further comparative tests were also carried out with ampicillin, chloramphenicol, colistin sulphate, colistin methane sulphonate, cycloserine, kanamycin, nitrofurantoin, polymyxin, streptomycin, and tetracycline, using groups of 20 strains of each of the main species selected at random from the total number of isolates. Of the total number of isolates a higher percentage was inhibited by ampicillin than by tetracycline or chloramphenicol. Ampicillin showed particularly high activity against certain species of bacteria and displayed an antibacterial spectrum not shown by any of the other antibiotics tested.

Full text

PDF
462

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACRED P., BROWN D. M., TURNER D. H., WILSON M. J. Pharmacology and chemotherapy of ampicillin--a new broad-spectrum penicillin. Br J Pharmacol Chemother. 1962 Apr;18:356–369. doi: 10.1111/j.1476-5381.1962.tb01416.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. AUHAGEN E., GLOXHUBER C., HECHT G., KNOTT T., OTEN H., RAUENBUSCH E., RISSE K. H., SCHMID J., SCHOLTAN W., WALTER A. M. [Ampicillin-Binotal, a broad spectrum penicillin]. Arzneimittelforschung. 1962 Aug;12:791–801. [PubMed] [Google Scholar]
  3. AYLIFFE G. A. Ampicillin inactivation and sensitivity of coliform bacilli. J Gen Microbiol. 1963 Feb;30:339–348. doi: 10.1099/00221287-30-2-339. [DOI] [PubMed] [Google Scholar]
  4. BRUMFITT W., PERCIVAL A., CARTER M. J. Treatment of urinary-tract infections with amphicillin. A clinical trial. Lancet. 1962 Jan 20;1(7221):130–133. doi: 10.1016/s0140-6736(62)91132-7. [DOI] [PubMed] [Google Scholar]
  5. GARROD L. P., SHOOTER R. A., CURWEN M. P. The results of chemotherapy in urinary infections. Br Med J. 1954 Oct 30;2(4845):1003–1008. doi: 10.1136/bmj.2.4895.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KNUDSEN E. T., ROLINSON G. N., STEVENS S. Absorption and excretion of "Penbritin". Br Med J. 1961 Jul 22;2(5246):198–200. doi: 10.1136/bmj.2.5246.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. LOWE G. H. The rapid detection of lactose fermentation in paracolon organisms by the demonstration of beta-D-galactosidase. J Med Lab Technol. 1962 Jan;19:21–25. [PubMed] [Google Scholar]
  8. PERCIVAL A., BRUMFITT W., DE LOUVOIS J. THE ROLE OF PENICILLINASE IN DETERMINING NATURAL AND ACQUIRED RESISTANCE OF GRAM-NEGATIVE BACTERIA TO PENICILLINS. J Gen Microbiol. 1963 Jul;32:77–89. doi: 10.1099/00221287-32-1-77. [DOI] [PubMed] [Google Scholar]
  9. ROLINSON G. N., STEVENS S. Microbiological studies on a new broad-spectrum penicilin, "Penbritin". Br Med J. 1961 Jul 22;2(5246):191–196. doi: 10.1136/bmj.2.5246.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SMITH J. T., HAMILTON-MILLER J. M. Differences between pencillinases from gram-positive and gram-negative bacteria. Nature. 1963 Mar 9;197:976–978. doi: 10.1038/197976a0. [DOI] [PubMed] [Google Scholar]
  11. SUTHERLAND R. THE NATURE OF THE INSENSITIVITY OF GRAM-NEGATIVE BACTERIA TOWARDS PENICILLINS. J Gen Microbiol. 1964 Jan;34:85–98. doi: 10.1099/00221287-34-1-85. [DOI] [PubMed] [Google Scholar]
  12. Stewart G. T., Coles H. M., Nixon H. H., Holt R. J. "Penbritin": An Oral Penicillin with Broad-spectrum Activity. Br Med J. 1961 Jul 22;2(5246):200–206. doi: 10.1136/bmj.2.5246.200. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES