Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1984 Dec;52(6):667–673. doi: 10.1136/hrt.52.6.667

Cardiac performance in various stages of renal failure.

S K Pehrsson, R Jonasson, L E Lins
PMCID: PMC481703  PMID: 6508967

Abstract

Cardiac catheterisation was performed to evaluate cardiac function in 12 patients with various stages of renal failure. All patients were studied at rest and during supine exercise to subjective exhaustion. Eight patients had a normal arteriovenous oxygen difference at rest and during exercise whereas three had a low arteriovenous oxygen difference and one a high arteriovenous oxygen difference. Left ventricular stroke work did not increase normally at transition from rest to exercise in most patients with serum creatinine concentrations greater than 500 mumol/l. The left ventricular end diastolic pressure was abnormally raised during exercise in all patients (range 20-42 mm Hg) and also at rest in most of them (range 8-36 mm Hg), indicating myocardial dysfunction. These observations suggest that patients have abnormal cardiac performance at a relatively early stage of renal failure.

Full text

PDF
670

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbasi A. S., Slaughter J. C., Allen M. W. Asymmetric septal hypertrophy in patients on long-term hemodialysis. Chest. 1978 Nov;74(5):548–551. doi: 10.1378/chest.74.5.548. [DOI] [PubMed] [Google Scholar]
  2. Ahearn D. J., Maher J. F. Heart failure as a complication of hemodialysis arteriovenous fistula. Ann Intern Med. 1972 Aug;77(2):201–204. doi: 10.7326/0003-4819-77-2-201. [DOI] [PubMed] [Google Scholar]
  3. Anderson C. B., Codd J. R., Graff R. A., Groce M. A., Harter H. R., Newton W. T. Cardiac failure and upper extremity arteriovenous dialysis fistulas. Case reports and a review of the literature. Arch Intern Med. 1976 Mar;136(3):292–297. [PubMed] [Google Scholar]
  4. Anderson C. B., Groce M. A. Banding of arteriovenous dialysis fistulas to correct high-output cardiac failure. Surgery. 1975 Nov;78(5):552–554. [PubMed] [Google Scholar]
  5. Aström H., Jonsson B. Design of exercise test, with special reference to heart patients. Br Heart J. 1976 Mar;38(3):289–296. doi: 10.1136/hrt.38.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bornstein A., Zambrano S. S., Morrison R. S., Spodick D. H. Cardiac effects of hemodialysis: noninvasive monitoring by systolic time intervals. Am J Med Sci. 1975 Mar-Apr;269(2):189–192. doi: 10.1097/00000441-197503000-00004. [DOI] [PubMed] [Google Scholar]
  7. Burke J. F., Jr, Francos G. C., Moore L. L., Cho S. Y., Lasker N. Accelerated atherosclerosis in chronic-dialysis patients--another look. Nephron. 1978;21(4):181–185. doi: 10.1159/000181391. [DOI] [PubMed] [Google Scholar]
  8. Capelli J. P., Kasparian H. Cardiac work demands and left ventricular function in end-stage renal disease. Ann Intern Med. 1977 Mar;86(3):261–267. doi: 10.7326/0003-4819-86-3-261. [DOI] [PubMed] [Google Scholar]
  9. Cohen M. V., Diaz P., Scheuer J. Echocardiographic assessment of left ventricular function in patients with chronic uremia. Clin Nephrol. 1979 Oct;12(4):156–162. [PubMed] [Google Scholar]
  10. D'Cruz I. A., Bhatt G. R., Cohen H. C., Glick G. Echocardiographic detection of cardiac involvement in patients with chronic renal failure. Arch Intern Med. 1978 May;138(5):720–724. [PubMed] [Google Scholar]
  11. DUSTAN H. P., PAGE I. H. SOME FACTORS IN RENAL AND RENOPRIVAL HYPERTENSION. J Lab Clin Med. 1964 Dec;64:948–959. [PubMed] [Google Scholar]
  12. Dongradi G., Dubois D., Bécart J., Coy J. L., Fendler J. P. Fonction myocardique de l'hémodialysé chronique. Evaluation par la mesure des intervalles de temps systoliques. Nouv Presse Med. 1977 Jun 4;6(23):2039–2042. [PubMed] [Google Scholar]
  13. Drüeke T., Fauchet M., Fleury J., Lesourd P., Toure Y., Le Pailleur C., de Vernejoul P., Crosnier J. Effect of parathyroidectomy on left-ventricular function in haemodialysis patients. Lancet. 1980 Jan 19;1(8160):112–114. doi: 10.1016/s0140-6736(80)90602-9. [DOI] [PubMed] [Google Scholar]
  14. Drüeke T., Le Pailleur C., Meilhac B., Koutoudis C., Zingraff J., Di Matteo J., Crosnier J. Congestive cardiomyopathy in uraemic patients on long term haemodialysis. Br Med J. 1977 Feb 5;1(6057):350–353. doi: 10.1136/bmj.1.6057.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Ejerblad S. Uraemic myocardial disease. An experimental study, with special reference to the effect of parathyroidectomy. Acta Chir Scand. 1979;145(5):345–353. [PubMed] [Google Scholar]
  16. Hull A. R., Long D. L., Prati R. C., Pettinger W. A., Parker T. F., 3rd The control of hypertension in patients undergoing regular maintenance hemodialysis. Kidney Int Suppl. 1975 Jan;(2):184–187. [PubMed] [Google Scholar]
  17. Hung J., Harris P. J., Uren R. F., Tiller D. J., Kelly D. T. Uremic cardiomyopathy--effect of hemodialysis on left ventricular function in end-stage renal failure. N Engl J Med. 1980 Mar 6;302(10):547–551. doi: 10.1056/NEJM198003063021003. [DOI] [PubMed] [Google Scholar]
  18. Ikäheimo M., Huttunen K., Takkunen J. Cardiac effects of chronic renal failure and haemodialysis treatment. Hypertensive versus normotensive patients. Br Heart J. 1981 Jun;45(6):710–716. doi: 10.1136/hrt.45.6.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Ireland M. A., Mehta B. R., Shiu M. F. Acute effects of haemodialysis on left heart dimensions and left ventricular function: an echocardiographic study. Nephron. 1981;29(1-2):73–79. doi: 10.1159/000182243. [DOI] [PubMed] [Google Scholar]
  20. Lai K. N., Barnden L., Mathew T. H. Effect of renal transplantation on left ventricular function in hemodialysis patients. Clin Nephrol. 1982 Aug;18(2):74–78. [PubMed] [Google Scholar]
  21. Lazarus J. M., Hampers C., Merrill J. P. Hypertension in chronic renal failure. Treatment with hemodialysis and nephrectomy. Arch Intern Med. 1974 Jun;133(6):1059–1066. [PubMed] [Google Scholar]
  22. Lazarus J. M., Lowrie E. G., Hampers C. L., Merrill J. P. Cardiovascular disease in uremic patients on hemodialysis. Kidney Int Suppl. 1975 Jan;(2):167–175. [PubMed] [Google Scholar]
  23. Lewis B. S., Milne F. J., Goldberg B. Left ventricular function in chronic renal failure. Br Heart J. 1976 Dec;38(12):1229–1239. doi: 10.1136/hrt.38.12.1229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lindner A., Charra B., Sherrard D. J., Scribner B. H. Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med. 1974 Mar 28;290(13):697–701. doi: 10.1056/NEJM197403282901301. [DOI] [PubMed] [Google Scholar]
  25. Massry S. G., Goldstein D. A. The search for uremic toxin(s) "X" "X" = PTH. Clin Nephrol. 1979 Apr;11(4):181–189. [PubMed] [Google Scholar]
  26. McGrath B. P., Ledingham J. G. Renin, blood volume and response to saralasin in patients on chronic haemodialysis: evidence against volume- and renin-'dependent' hypertension. Clin Sci Mol Med. 1978 Mar;54(3):305–312. doi: 10.1042/cs0540305. [DOI] [PubMed] [Google Scholar]
  27. Miach P. J., Dawborn J. K., Louis W. J., McDonald I. G. Left ventricular function in uremia: echocardiographic assessment in patients on maintenance dialysis. Clin Nephrol. 1981 May;15(5):259–263. [PubMed] [Google Scholar]
  28. Nicholls A. J., Catto G. R., Edward N., Engeset J., Macleod M. Accelerated atherosclerosis in long-term dialysis and renal-transplant patients: fact or fiction? Lancet. 1980 Feb 9;1(8163):276–278. doi: 10.1016/s0140-6736(80)90777-1. [DOI] [PubMed] [Google Scholar]
  29. Pehrsson S. K., Lins L. E. The role of trace elements in uremic heart failure. Nephron. 1983;34(2):93–98. doi: 10.1159/000182989. [DOI] [PubMed] [Google Scholar]
  30. Prosser D., Parsons V. EDITORIAL: The case for a specific uraemic myocardopathy. Nephron. 1975;15(1):4–7. doi: 10.1159/000180487. [DOI] [PubMed] [Google Scholar]
  31. Riley S. M., Jr, Blackstone E. H., Sterling W. A., Diethelm A. G. Echocardiographic assessment of cardiac performance in patients with arteriovenous fistulas. Surg Gynecol Obstet. 1978 Feb;146(2):203–208. [PubMed] [Google Scholar]
  32. Scharf S., Wexler J., Longnecker R. E., Blaufox M. D. Cardiovascular disease in patients on chronic hemodialytic therapy. Prog Cardiovasc Dis. 1980 Mar-Apr;22(5):343–356. doi: 10.1016/0033-0620(80)90027-4. [DOI] [PubMed] [Google Scholar]
  33. Varat M. A., Adolph R. J., Fowler N. O. Cardiovascular effects of anemia. Am Heart J. 1972 Mar;83(3):415–426. doi: 10.1016/0002-8703(72)90445-0. [DOI] [PubMed] [Google Scholar]
  34. Vertes V., Cangiano J. L., Berman L. B., Gould A. Hypertension in end-stage renal disease. N Engl J Med. 1969 May 1;280(18):978–981. doi: 10.1056/NEJM196905012801802. [DOI] [PubMed] [Google Scholar]
  35. Warrier E. R., Balakrishnan K. G., Sankaran K., Gupta G. D. Systolic time intervals in chronic severe anaemia and effect of diuretic and digitalis. Br Heart J. 1981 Jul;46(1):80–83. doi: 10.1136/hrt.46.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Wing A. J., Brunner F. P., Brynger H., Chantler C., Donckerwolcke R. A., Gurland H. J., Hathway R. A., Jacobs C., Selwood N. H. Combined report on regular dialysis and transplantation in Europe, VIII, 1977. Proc Eur Dial Transplant Assoc. 1978;15:2–76. [PubMed] [Google Scholar]
  37. de Planque B. A., Mulder E., Mees E. J. The behaviour of blood and extracellular volume in hypertensive patients with renal insufficiency. Acta Med Scand. 1969 Jul-Aug;186(1-2):75–81. doi: 10.1111/j.0954-6820.1969.tb01442.x. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES