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. 1992 Jan 1;89(1):232–235. doi: 10.1073/pnas.89.1.232

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

S Suematsu 1, T Matsusaka 1, T Matsuda 1, S Ohno 1, J Miyazaki 1, K Yamamura 1, T Hirano 1, T Kishimoto 1
PMCID: PMC48210  PMID: 1729694

Abstract

The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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