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. 1981 May;45(5):487–493. doi: 10.1136/hrt.45.5.487

Critical analysis of endomyocardial biopsies from patients suspected of having cardiomyopathy. II: Comparison of histology and clinical/haemodynamic information.

U Baandrup, R A Florio, M Rehahn, P J Richardson, E G Olsen
PMCID: PMC482554  PMID: 7195269

Abstract

Endomyocardial biopsies showing histological evidence of "ordinary" hypertrophy or changes compatible with congestive cardiomyopathy (COCM) were obtained from 125 patients. Statistical analysis compared histological/morphometric data with clinical/haemodynamic findings such as ejection fraction, left ventricular end-diastolic pressure, and length of history. Patients were grouped either according to the histological description or the clinical diagnosis. Comparison of the morphological description with the final clinical diagnosis was also undertaken. Follow-up of the patients was between two and 66 months. The results of the statistical analyses showed no correlation between quantitative, morphological assessment and either clinical information, that is length of history and subsequent course, or the haemodynamic variables. In 86 per cent of cases a rough agreement between the morphological description and the clinical diagnosis was obtained, but no specific pattern permitting a morphological diagnosis of COCM was established. The findings suggest that pronounced topographic variation in biopsy material exists and that, therefore, the severity of COCM or its prognosis cannot be assessed from histological changes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Billingham M. E. Some recent advances in cardiac pathology. Hum Pathol. 1979 Jul;10(4):367–386. doi: 10.1016/s0046-8177(79)80043-x. [DOI] [PubMed] [Google Scholar]
  2. Davies M. J., Brooksby I. A., Jenkins B. S., Darracott S. C., Swanton R. H., Coltart J., Webb-Peploe M. M. Left ventricular endomyocardial biopsy. II: the value of light microscopy. Cathet Cardiovasc Diagn. 1977;3(2):123–130. doi: 10.1002/ccd.1810030205. [DOI] [PubMed] [Google Scholar]
  3. Gau G. T., Goodwin J. F., Oakley C. M., Olsen E. G., Rahimtoola S. H., Raphael M. J., Steiner R. E. Q waves and coronary arteriography in cardiomyopathy. Br Heart J. 1972 Oct;34(10):1034–1041. doi: 10.1136/hrt.34.10.1034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greene D. G., Carlisle R., Grant C., Bunnell I. L. Estimation of left ventricular volume by one-plane cineangiography. Circulation. 1967 Jan;35(1):61–69. doi: 10.1161/01.cir.35.1.61. [DOI] [PubMed] [Google Scholar]
  5. Hatle L., Melbye O. J. Immunoglobulins and complement in chronic myocardial disease. A myocardial biopsy study. Acta Med Scand. 1976;200(5):385–389. doi: 10.1111/j.0954-6820.1976.tb08251.x. [DOI] [PubMed] [Google Scholar]
  6. KONNO S., SAKAKIBARA S. ENDO-MYOCARDIAL BIOPSY. Dis Chest. 1963 Oct;44:345–350. doi: 10.1378/chest.44.4.345. [DOI] [PubMed] [Google Scholar]
  7. MacKay E. H., Littler W. A., Sleight P. Critical assessment of diagnostic value of endomyocardial biopsy. Assessment of cardiac biopsy. Br Heart J. 1978 Jan;40(1):69–78. doi: 10.1136/hrt.40.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Olsen E. G. Diagnostic value of the endomyocardial bioptome. Lancet. 1974 Apr;1(7859):658–660. doi: 10.1016/s0140-6736(74)93203-6. [DOI] [PubMed] [Google Scholar]
  9. Peters T. J., Brooksby I. A., Webb-Peploe M. M., Wells G., Jenkins B. S., Coltart D. J. Enzymic analysis of cardiac biopsy material from patients with valvular heart-disease. Lancet. 1976 Feb 7;1(7954):269–270. doi: 10.1016/s0140-6736(76)91401-x. [DOI] [PubMed] [Google Scholar]
  10. Peters T. J., Wells G., Oakley C. M., Brooksby I. A., Jenkins B. S., Webb-Peploe M. M., Coltart D. J. Enzymic analysis of endomyocardial biopsy specimens from patients with cardiomyopathies. Br Heart J. 1977 Dec;39(12):1333–1339. doi: 10.1136/hrt.39.12.1333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Richardson P. J., Livesley B., Oram S., Olsen E. G., Armstrong P. Angina pectoris with normal coronary arteries. Transvenous myocardial biopsy in diagnosis. Lancet. 1974 Sep 21;2(7882):677–680. doi: 10.1016/s0140-6736(74)93260-7. [DOI] [PubMed] [Google Scholar]
  12. SAKAKIBARA S., KONNO S. Endomyocardial biopsy. Jpn Heart J. 1962 Nov;3:537–543. doi: 10.1536/ihj.3.537. [DOI] [PubMed] [Google Scholar]
  13. SELDINGER S. I. Catheter replacement of the needle in percutaneous arteriography; a new technique. Acta radiol. 1953 May;39(5):368–376. doi: 10.3109/00016925309136722. [DOI] [PubMed] [Google Scholar]
  14. Sandler H., Dodge H. T. The use of single plane angiocardiograms for the calculation of left ventricular volume in man. Am Heart J. 1968 Mar;75(3):325–334. doi: 10.1016/0002-8703(68)90089-6. [DOI] [PubMed] [Google Scholar]
  15. Sekiguchi M., Konno S. Diagnosis and classification of primary myocardial disease with the aid of endomyocardial biopsy. Jpn Circ J. 1971 Jul;35(7):737–754. doi: 10.1253/jcj.35.737. [DOI] [PubMed] [Google Scholar]
  16. Somers K., Hutt M. S., Patel A. K., D'Arbela P. G. Endomyocardial biopsy in diagnosis of cardiomyopathies. Br Heart J. 1971 Nov;33(6):822–832. doi: 10.1136/hrt.33.6.822. [DOI] [PMC free article] [PubMed] [Google Scholar]

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