Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1981 Jul;46(1):80–83. doi: 10.1136/hrt.46.1.80

Systolic time intervals in chronic severe anaemia and effect of diuretic and digitalis.

E R Warrier, K G Balakrishnan, K Sankaran, G D Gupta
PMCID: PMC482606  PMID: 7272117

Abstract

Systolic time intervals were measured from simultaneous high speed recordings of the electrocardiogram, phonocardiogram, and carotid artery pulse in 15 men with chronic severe anaemia not in heart failure and with a normal heart size, and in 15 normal men. Heart rates, electromechanical systole (QS2), pre-ejection period index (PEPI), left ventricular ejection time index (LVETI), and the ratio of pre-ejection period to left ventricular ejection time (PEP/LVET) did not differ significantly in the two groups. After the intravenous administration of frusemide in 10 of the anaemic patients, the pre-ejection period index was prolonged, the PEP/LVET ratio increased, heart rate increased, and the left ventricular ejection time index shortened. Intravenous digoxin did not alter the QS2 interval and heart rate significantly in the anaemic subjects. Left ventricular function in chronic severe anaemia as measured by systolic time intervals does not differ from that of normal controls. The effect of frusemide on the systolic time intervals is explained as an effect of the fall in preload, bringing cardiac function further down on the ascending limb of the Frank-Starling curve. Other related studies are discussed.

Full text

PDF
83

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdullah A. K., Siddiqui M. A., Tajuddin M. Systolic time intervals in chronic anemia. Am Heart J. 1977 Sep;94(3):287–291. doi: 10.1016/s0002-8703(77)80470-5. [DOI] [PubMed] [Google Scholar]
  2. Ahmed S. S., Jaferi G. A., Narang R. M., Regan T. J. Preclinical abnormality of left ventricular function in diabetes mellitus. Am Heart J. 1975 Feb;89(2):153–158. doi: 10.1016/0002-8703(75)90039-3. [DOI] [PubMed] [Google Scholar]
  3. EICHNA L. W., FARBER S. J., BERGER A. R., RADER B., SMITH W. W., ALBERT R. E. Non-cardiac circulatory congestion simulating congestive heart failure. Trans Assoc Am Physicians. 1954;67:72–85. [PubMed] [Google Scholar]
  4. EICHNA L. W. The George E. Brown Memorial Lecture: Circulatory congestion and heart failure. Circulation. 1960 Nov;22:864–886. doi: 10.1161/01.cir.22.5.864. [DOI] [PubMed] [Google Scholar]
  5. Escobar E., Jones N. L., Rapaport E., Murray J. F. Ventricular performance in acute normovolemic anemia and effects of beta blockade. Am J Physiol. 1966 Oct;211(4):877–884. doi: 10.1152/ajplegacy.1966.211.4.877. [DOI] [PubMed] [Google Scholar]
  6. Guleria J. S., Pande J. N., Markose M. M., Gupta R. G., Jain B. P. Pulmonary function in chronic severe anaemia. Clin Sci. 1971 Apr;40(4):317–325. doi: 10.1042/cs0400317. [DOI] [PubMed] [Google Scholar]
  7. HARRISON T. R., DIXON K., RUSSELL R. O., Jr, BIDWAI P. S., COLEMAN H. N. THE RELATION OF AGE TO THE DURATION OF CONTRACTION, EJECTION, AND RELAXATION OF THE NORMAL HUMAN HEART. Am Heart J. 1964 Feb;67:189–199. doi: 10.1016/0002-8703(64)90370-9. [DOI] [PubMed] [Google Scholar]
  8. Manchanda S. C., Bansal R., Soni V., Roy S. B. Systolic time intervals in chronic severe anaemia. Indian Heart J. 1974 Jan;26(1):32–34. [PubMed] [Google Scholar]
  9. McConahay D. R., Martin C. M., Cheitlin M. D. Resting and exercise systolic time intervals. Correlations with ventricular performance in patients with coronary artery disease. Circulation. 1972 Mar;45(3):592–601. doi: 10.1161/01.cir.45.3.592. [DOI] [PubMed] [Google Scholar]
  10. RANKIN J., McNEILL R. S., FORSTER R. E. The effect of anemia on the alveolar-capillary exchange of carbon monoxide in man. J Clin Invest. 1961 Jul;40:1323–1330. doi: 10.1172/JCI104362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SOMERS K. Acute reversible heart failure in severe iron-deficiency anemia associated with hookworm infestation in Uganda Africans. Circulation. 1959 May;19(5):672–675. doi: 10.1161/01.cir.19.5.672. [DOI] [PubMed] [Google Scholar]
  12. Weissler A. M., Garrard C. L., Jr Systolic time intervals in cardiac disease. I. Mod Concepts Cardiovasc Dis. 1971 Jan;40(1):1–4. [PubMed] [Google Scholar]
  13. Weissler A. M., Harris W. S., Schoenfeld C. D. Bedside technics for the evaluation of ventricular function in man. Am J Cardiol. 1969 Apr;23(4):577–583. doi: 10.1016/0002-9149(69)90012-5. [DOI] [PubMed] [Google Scholar]
  14. Weissler A. M., Harris W. S., Schoenfeld C. D. Systolic time intervals in heart failure in man. Circulation. 1968 Feb;37(2):149–159. doi: 10.1161/01.cir.37.2.149. [DOI] [PubMed] [Google Scholar]
  15. Weissler A. M., Schoenfeld C. D. Effect of digitalis on systolic time intervals in heart failure. Am J Med Sci. 1970 Jan;259(1):4–20. doi: 10.1097/00000441-197001000-00002. [DOI] [PubMed] [Google Scholar]
  16. Willems J. L., Roelandt J., De Geest H., Kesteloot H., Joossens J. V. The left ventricular ejection time in elderly subjects. Circulation. 1970 Jul;42(1):37–42. doi: 10.1161/01.cir.42.1.37. [DOI] [PubMed] [Google Scholar]
  17. Wu C. F., Sudhaker M., Ghazanfar J., Ahmed S. S., Regan T. J. Preclinical cardiomyopathy in chronic alcoholics: a sex difference. Am Heart J. 1976 Mar;91(3):281–286. doi: 10.1016/s0002-8703(76)80209-8. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES