Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1981 Aug;46(2):168–172. doi: 10.1136/hrt.46.2.168

Arrhythmia in hypertrophic cardiomyopathy. I: Influence on prognosis.

W J McKenna, D England, Y L Doi, J E Deanfield, C Oakley, J F Goodwin
PMCID: PMC482623  PMID: 7196768

Abstract

In order to examine the association between arrhythmia and subsequent prognosis, 72-hour ambulatory electrocardiographic monitoring was performed in 86 unselected patients with hypertrophic cardiomyopathy. During monitoring 23 patients experienced at least one episode of supraventricular tachycardia and 24 had ventricular tachycardia (of whom 10 had more than three episodes). The patients were then followed for a mean of 2.6 years (range one to four). Seven patients died suddenly. Of these, five had exhibited multiform and paired ventricular extrasystoles and ventricular tachycardia. These arrhythmias were significantly associated with sudden death whereas supraventricular arrhythmias were not. The patients who died suddenly were older and had experienced more symptoms than the survivors, and three had a family history of hypertrophic cardiomyopathy and sudden death. This experience provides the basis for the assessment of treatment in patients with hypertrophic cardiomyopathy and serious ventricular arrhythmia.

Full text

PDF
168

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAUNWALD E., LAMBREW C. T., ROCKOFF S. D., ROSS J., Jr, MORROW A. G. IDIOPATHIC HYPERTROPHIC SUBAORTIC STENOSIS. I. A DESCRIPTION OF THE DISEASE BASED UPON AN ANALYSIS OF 64 PATIENTS. Circulation. 1964 Nov;30:SUPPL 4–119. doi: 10.1161/01.cir.29.5s4.iv-3. [DOI] [PubMed] [Google Scholar]
  2. Doi Y. L., McKenna W. J., Gehrke J., Oakley C. M., Goodwin J. F. M mode echocardiography in hypertrophic cardiomyopathy: diagnostic criteria and prediction of obstruction. Am J Cardiol. 1980 Jan;45(1):6–14. doi: 10.1016/0002-9149(80)90213-1. [DOI] [PubMed] [Google Scholar]
  3. Gilbert B. W., Pollick C., Adelman A. G., Wigle E. D. Hypertrophic cardiomyopathy: subclassification by m mode echocardiography. Am J Cardiol. 1980 Apr;45(4):861–872. doi: 10.1016/0002-9149(80)90133-2. [DOI] [PubMed] [Google Scholar]
  4. Hardarson T., De la Calzada C. S., Curiel R., Goodwin J. F. Prognosis and mortality of hypertrophic obstructive cardiomyopathy. Lancet. 1973 Dec 29;2(7844):1462–1467. doi: 10.1016/s0140-6736(73)92730-x. [DOI] [PubMed] [Google Scholar]
  5. Maron B. J., Henry W. L., Clark C. E., Redwood D. R., Roberts W. C., Epstein S. E. Asymetric septal hypertrophy in childhood. Circulation. 1976 Jan;53(1):9–19. doi: 10.1161/01.cir.53.1.9. [DOI] [PubMed] [Google Scholar]
  6. Maron B. J., Lipson L. C., Roberts W. C., Savage D. D., Epstein S. E. "Malignant" hypertrophic cardiomyopathy: identification of a subgroup of families with unusually frequent premature death. Am J Cardiol. 1978 Jun;41(7):1133–1140. doi: 10.1016/0002-9149(78)90870-6. [DOI] [PubMed] [Google Scholar]
  7. Maron B. J., Roberts W. C., Edwards J. E., McAllister H. A., Jr, Foley D. D., Epstein S. E. Sudden death in patients with hypertrophic cardiomyopathy: characterization of 26 patients with functional limitation. Am J Cardiol. 1978 May 1;41(5):803–810. doi: 10.1016/0002-9149(78)90717-8. [DOI] [PubMed] [Google Scholar]
  8. McKenna W. J., Chetty S., Oakley C. M., Goodwin J. F. Arrhythmia in hypertrophic cardiomyopathy: exercise and 48 hour ambulatory electrocardiographic assessment with and without beta adrenergic blocking therapy. Am J Cardiol. 1980 Jan;45(1):1–5. doi: 10.1016/0002-9149(80)90212-x. [DOI] [PubMed] [Google Scholar]
  9. McKenna W., Deanfield J., Faruqui A., England D., Oakley C., Goodwin J. Prognosis in hypertrophic cardiomyopathy: role of age and clinical, electrocardiographic and hemodynamic features. Am J Cardiol. 1981 Mar;47(3):532–538. doi: 10.1016/0002-9149(81)90535-x. [DOI] [PubMed] [Google Scholar]
  10. Ryan M., Lown B., Horn H. Comparison of ventricular ectopic activity during 24-hour monitoring and exercise testing in patients with coronary heart disease. N Engl J Med. 1975 Jan 30;292(5):224–229. doi: 10.1056/NEJM197501302920502. [DOI] [PubMed] [Google Scholar]
  11. Savage D. D., Seides S. F., Maron B. J., Myers D. J., Epstein S. E. Prevalence of arrhythmias during 24-hour electrocardiographic monitoring and exercise testing in patients with obstructive and nonobstructive hypertrophic cardiomyopathy. Circulation. 1979 May;59(5):866–875. doi: 10.1161/01.cir.59.5.866. [DOI] [PubMed] [Google Scholar]
  12. Simon A. L., Ross J., Jr, Gault J. H. Angiographic anatomy of the left ventricle and mitral valve in idiopathic hypertrophic subaortic stenosis. Circulation. 1967 Dec;36(6):852–867. doi: 10.1161/01.cir.36.6.852. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES