Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1975 May;37(5):486–492. doi: 10.1136/hrt.37.5.486

Effect of quinidine on maintaining sinus rhythm after conversion of atrial fibrillation or flutter. A multicentre study from Stockholm.

T Södermark, B Jonsson, A Olsson, L Orö, H Wallin, O Edhag, A Sjögren, M Danielsson, G Rosenhamer
PMCID: PMC482826  PMID: 1093559

Abstract

In a controlled study comprising 176 patients, quinidine in the form of Kinidin Durules was found to reduced significantly the recurrence of the atrial fibrillation during a 1-year follow-up period after successful electric shock conversion. After one year, 51 per cent (52/101) of the patients in the quinidine group, and 28 per cent (21/75) in the control group remained in sinus rhythm (P smaller than 0.001). No less than 43 per cent of the patients converted to sinus rhythm during treatment with maintenance doses of quinidine sulphate before intended DC conversion. Gastrointestinal side-effects were not uncommon, and caused interruption of quinidine treatment in some cases.

Full text

PDF
486

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjerkelund C., Orning O. M. An evaluation of DC shock treatment of atrial arrhythmias. Acta Med Scand. 1968 Dec;184(6):481–491. doi: 10.1111/j.0954-6820.1968.tb02489.x. [DOI] [PubMed] [Google Scholar]
  2. Byrne-Quinn E., Wing A. J. Maintenance of sinus rhythm after DC reversion of atrial fibrilllation. A double-blind controlled trial of long-acting quinidine bisulphate. Br Heart J. 1970 May;32(3):370–376. doi: 10.1136/hrt.32.3.370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CRAMER G., VARNAUSKAS E., WERKO L. A new quinidine preparation with sustained release. Acta Med Scand. 1963 Apr;173:511–519. doi: 10.1111/j.0954-6820.1963.tb17435.x. [DOI] [PubMed] [Google Scholar]
  4. Gunning J. F., Kristinsson A., Miller G., Saunders K. Long-term follow-up of direct current cardioversion after cardiac surgery with special reference to quinidine. Br Heart J. 1970 Jul;32(4):462–466. doi: 10.1136/hrt.32.4.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hall J. I., Wood D. R. Factors affecting cardioversion of atrial arrhythmias with special reference to quinidine. Br Heart J. 1968 Jan;30(1):84–90. doi: 10.1136/hrt.30.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Halmos P. B. Direct current conversion of atrial fibrillation. Br Heart J. 1966 May;28(3):302–308. doi: 10.1136/hrt.28.3.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hillestad L., Dale J., Storstein O. Quinidine before direct current countershock. A controlled study. Br Heart J. 1972 Feb;34(2):139–142. doi: 10.1136/hrt.34.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Härtel G., Louhija A., Konttinen A., Halonen P. I. Value of quinidine in maintenance of sinus rhythm after electric conversion of atrial fibrillation. Br Heart J. 1970 Jan;32(1):57–60. doi: 10.1136/hrt.32.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. LOWN B., AMARASINGHAM R., NEUMAN J. New method for terminating cardiac arrhythmias. Use of synchronized capacitor discharge. JAMA. 1962 Nov 3;182:548–555. [PubMed] [Google Scholar]
  10. Lown B. Electrical reversion of cardiac arrhythmias. Br Heart J. 1967 Jul;29(4):469–489. doi: 10.1136/hrt.29.4.469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. ORAM S., DAVIES J. P. FURTHER EXPERIENCE OF ELECTRICAL CONVERSION OF ATRIAL FIBRILLATION TO SINUS RHYTHM: ANALYSIS OF 100 PATIENTS. Lancet. 1964 Jun 13;1(7346):1294–1298. doi: 10.1016/s0140-6736(64)91692-7. [DOI] [PubMed] [Google Scholar]
  12. ROKSETH R. CLINICAL CONSIDERATIONS IN QUINIDINE THERAPY OF CHRONIC AURICULAR FIBRILLATION. A STUDY OF 200 UNSELECTED PATIENTS--WITH FOLLOW-UP. Acta Med Scand. 1963 Aug;174:171–178. doi: 10.1111/j.0954-6820.1963.tb07908.x. [DOI] [PubMed] [Google Scholar]
  13. Resnekov L., Gibson D., Waich S., Muir J., McDonald L. Sustained-release quinidine (Kinidin Durules) in maintaining sinus rhythm after electroversion of atrial dysrhythmias. Br Heart J. 1971 Mar;33(2):220–225. doi: 10.1136/hrt.33.2.220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Resnekov L., McDonald L. Electroversion of lone atrial fibrillation and flutter including haemodynamic studies at rest and on exercise. Br Heart J. 1971 May;33(3):339–350. doi: 10.1136/hrt.33.3.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rossi M., Lown B. The use of quinidine in cardioversion. Am J Cardiol. 1967 Feb;19(2):234–238. doi: 10.1016/0002-9149(67)90539-5. [DOI] [PubMed] [Google Scholar]
  16. SANDOE E., HANSEN P. F., ARNFRED E., OLESEN K. H. DEFIBRILLERING AF KRONISK ATRIEFLIMREN. RESULTATER OG KOMPLIKATIONER. Ugeskr Laeger. 1965 Mar 11;127:346–351. [PubMed] [Google Scholar]
  17. Szekely P., Sideris D. A., Batson G. A. Maintenance of sinus rhythm after atrial defibrillation. Br Heart J. 1970 Nov;32(6):741–746. doi: 10.1136/hrt.32.6.741. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Takkunen J., Oilinki O., Salokannel J., Vuopala U. Mortality of patients with atrial fibrillation before and after introduction of DC counter shock therapy. Acta Med Scand. 1970 Jul-Aug;1-2(1):127–131. doi: 10.1111/j.0954-6820.1970.tb08015.x. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES