Skip to main content
British Heart Journal logoLink to British Heart Journal
. 1977 Sep;39(9):967–973. doi: 10.1136/hrt.39.9.967

Origin of ventricular reflexes caused by coronary arteriography.

F Perez-Gomez, A Garcia-Aguado
PMCID: PMC483355  PMID: 907775

Abstract

Left ventricular reflexes have in the past been investigated in anaesthetised animals, generally using an open chest technique. We have studied the degree of bradycardia occurring during coronary arteriography in 200 patients with a view to localising the origin of the ventricular reflexes. We have correlated the decrease of sinus rate with the anatomical distribution and integrity of the coronary tree. The degree of bradycardia was not influenced by the origin of the sinus node or the AV node arteries, while there was a good correlation with the injection of contrast medium into the artery which supplied the inferior wall of the left ventricle. The occurrence of transient sinus arrest was also correlated with the injection into the same artery. The results suggest that the parasympathetic receptors are located mainly in the inferior wall of the left ventricle. This may well be the explanation for the clinical picture of bradycardia, hypotension, and peripheral vasodilatation often seen in acute inferior myocardial infarction.

Full text

PDF
970

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AGRESS C. M., GLASSNER H. F., BINDER M. J., FIELDS J. Hemodynamic measurements in experimental coronary shock. J Appl Physiol. 1957 May;10(3):469–475. doi: 10.1152/jappl.1957.10.3.469. [DOI] [PubMed] [Google Scholar]
  2. Adgey A. A., Geddes J. S., Mulholland H. C., Keegan D. A., Pantridge J. F. Incidence, significance, and management of early bradyarrhythmia complicating acute myocardial infarction. Lancet. 1968 Nov 23;2(7578):1097–1101. doi: 10.1016/s0140-6736(68)91577-8. [DOI] [PubMed] [Google Scholar]
  3. COSTANTIN L. Extracardiac factors contributing to hypotension during coronary occlusion. Am J Cardiol. 1963 Feb;11:205–217. doi: 10.1016/0002-9149(63)90062-6. [DOI] [PubMed] [Google Scholar]
  4. Carson R. P., Lazzara R. Hemodynamic responses initiated by coronary stretch receptors with special reference to coronary arteriography. Am J Cardiol. 1970 May;25(5):571–578. doi: 10.1016/0002-9149(70)90596-5. [DOI] [PubMed] [Google Scholar]
  5. Fluck D. C., Olsen E., Pentecost B. L., Thomas M., Fillmore S. J., Shillingford J. P., Mounsey J. P. Natural history and clinical significance of arrhythmias after acute cardiac infarction. Br Heart J. 1967 Mar;29(2):170–189. doi: 10.1136/hrt.29.2.170. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. George M., Greenwood T. W. Relation between bradycardia and the site of myocardial infarction. Lancet. 1967 Oct 7;2(7519):739–740. doi: 10.1016/s0140-6736(67)91944-7. [DOI] [PubMed] [Google Scholar]
  7. Hanley H. G., Costin J. C., Skinner N. S., Jr Differential reflex adjustments in cutaneous and muscle vascular beds during experimental coronary artery occlusion. Am J Cardiol. 1971 May;27(5):513–521. doi: 10.1016/0002-9149(71)90414-0. [DOI] [PubMed] [Google Scholar]
  8. Hanley H. G., Raizner A. E., Inglesby T. V., Skinner N. S., Jr Response of the renal vascular bed to acute experimental coronary arterial occlusion. Am J Cardiol. 1972 Jun;29(6):803–808. doi: 10.1016/0002-9149(72)90498-5. [DOI] [PubMed] [Google Scholar]
  9. JULIAN D. G., VALENTINE P. A., MILLER G. G. DISTURBANCES OF RATE, RHYTHM AND CONDUCTION IN ACUTE MYOCARDIAL INFARCTION: A PROSPECTIVE STUDY OF 100 CONSECUTIVE UNSELECTED PATIENTS WITH THE AID OF ELECTROCARDIOGRAPHIC MONITORING. Am J Med. 1964 Dec;37:915–927. doi: 10.1016/0002-9343(64)90133-0. [DOI] [PubMed] [Google Scholar]
  10. Judkins M. P. Percutaneous transfemoral selective coronary arteriography. Radiol Clin North Am. 1968 Dec;6(3):467–492. [PubMed] [Google Scholar]
  11. Kezdi P., Kordenat R. K., Misra S. N. Reflex inhibitory effects of vagal afferents in experimental myocardial infarction. Am J Cardiol. 1974 Jun;33(7):853–860. doi: 10.1016/0002-9149(74)90632-8. [DOI] [PubMed] [Google Scholar]
  12. Kuhn L. A. The treatment of cardiogenic shock. I. The nature of cardiogenic shock. Am Heart J. 1967 Oct;74(4):578–581. doi: 10.1016/0002-8703(67)90019-1. [DOI] [PubMed] [Google Scholar]
  13. Liden R. J. Reflexes from the heart. Prog Cardiovasc Dis. 1975 Nov-Dec;18(3):201–221. doi: 10.1016/0033-0620(75)90011-0. [DOI] [PubMed] [Google Scholar]
  14. Oberg B., Thorén P. Studies on left ventricular receptors, signalling in non-medullated vagal afferents. Acta Physiol Scand. 1972 Jun;85(2):145–163. doi: 10.1111/j.1748-1716.1972.tb05246.x. [DOI] [PubMed] [Google Scholar]
  15. SONES F. M., Jr, SHIREY E. K. Cine coronary arteriography. Mod Concepts Cardiovasc Dis. 1962 Jul;31:735–738. [PubMed] [Google Scholar]
  16. Sleight P., Widdicombe J. G. Action potentials in fibres from receptors in the epicardium and myocardium of the dog's left ventricle. J Physiol. 1965 Nov;181(2):235–258. doi: 10.1113/jphysiol.1965.sp007758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thomas M., Woodgate D. Effect of atropine on bradycardia and hypotension in acute myocardial infarction. Br Heart J. 1966 May;28(3):409–413. doi: 10.1136/hrt.28.3.409. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES