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. 1978 Dec;40(12):1371–1375. doi: 10.1136/hrt.40.12.1371

Observations on intravenous administration of lignocaine in patients with myocardial infarction.

N P Campbell, J G Kelly, A A Adgey, D G McDevitt, J F Pantridge
PMCID: PMC483581  PMID: 737094

Abstract

Lignocaine was administered intravenously to 36 patients with acute myocardial infarction. A bolus of 100 mg followed by an infusion of 2 mg/minute failed to maintain plasma levels above 2 microgram/ml. A bolus of 100 mg followed by 4 mg/minute also failed to maintain satisfactory plasma concentrations during the first hour of therapy. A bolus of 75 mg was combined with an infusion of 10 mg/minute for 20 minutes followed by 1.5 mg/minute. Satisfactory plasma concentrations during the first hour were observed in 94 per cent of the estimations. No important adverse side effects occurred during the infusion of 10 mg/minute.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aps C., Bell J. A., Jenkins B. S., Poole-Wilson P. A., Reynolds F. Logical approach to lignocaine therapy. Br Med J. 1976 Jan 3;1(6000):13–15. doi: 10.1136/bmj.1.6000.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bassan M. M., Weinstein S. R., Mandel W. J. Use of lidocaine by continuous infusion. Am Heart J. 1974 Mar;87(3):302–303. doi: 10.1016/0002-8703(74)90069-6. [DOI] [PubMed] [Google Scholar]
  3. Collinsworth K. A., Kalman S. M., Harrison D. C. The clinical pharmacology of lidocaine as an antiarrhythymic drug. Circulation. 1974 Dec;50(6):1217–1230. doi: 10.1161/01.cir.50.6.1217. [DOI] [PubMed] [Google Scholar]
  4. Evans E. F., Proctor J. D., Fratkin M. J., Velandia J., Wasserman A. J. Blood flow in muscle groups and drug absorption. Clin Pharmacol Ther. 1975 Jan;17(1):44–47. doi: 10.1002/cpt197517144. [DOI] [PubMed] [Google Scholar]
  5. Gamble O. W., Cohn K. Effect of propranolol, procainamide, and lidocaine on ventricular automaticity and reentry in experimental myocardial infarction. Circulation. 1972 Sep;46(3):498–506. doi: 10.1161/01.cir.46.3.498. [DOI] [PubMed] [Google Scholar]
  6. Geddes J. S., Webb S. W., Adgey A. A. Letter: Effect of lidocaine on "gating" mechanism. Am Heart J. 1974 Aug;88(2):260–261. doi: 10.1016/0002-8703(74)90024-6. [DOI] [PubMed] [Google Scholar]
  7. Geddes J. S., Webb S., Pantridge J. F. Limitations of lignocaine in control of early ventricular dysrhythmias complicating acute myocardial infarction. Br Heart J. 1972 Sep;34(9):964–965. [PubMed] [Google Scholar]
  8. Greenblatt D. J., Bolognini V., Koch-Weser J., Harmatz J. S. Pharmacokinetic approach to the clinical use of lidocaine intravenously. JAMA. 1976 Jul 19;236(3):273–277. [PubMed] [Google Scholar]
  9. Grossman J. I., Cooper J. A., Frieden J. Cardiovascular effects of infusion of lidocaine on patients with heart disease. Am J Cardiol. 1969 Aug;24(2):191–197. doi: 10.1016/0002-9149(69)90403-2. [DOI] [PubMed] [Google Scholar]
  10. Koch-Weser J. Antiarrhythmic prophylaxis in ambulatory patients with coronary heart disease. Arch Intern Med. 1972 May;129(5):763–772. [PubMed] [Google Scholar]
  11. Levy R. A., Charuzi Y., Mandel W. J. Lignocaine: a new technique for intravenous administration. Br Heart J. 1977 Sep;39(9):1026–1028. doi: 10.1136/hrt.39.9.1026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Schwartz M. L., Meyer M. B., Covino B. G., Narang R. M., Sethi V., Schwartz A. J., Kamp P. Antiarrhythmic effectiveness of intramuscular lidocaine: influence of different injection sites. J Clin Pharmacol. 1974 Feb-Mar;14(2):77–83. doi: 10.1002/j.1552-4604.1974.tb02293.x. [DOI] [PubMed] [Google Scholar]
  13. Sheridan D. J., Crawford L., Rawlins M. D., Julian D. G. Antiarrhythmic action of lignocaine in early myocardial infarction. Plasma levels after combined intramuscular and intravenous administration. Lancet. 1977 Apr 16;1(8016):824–825. doi: 10.1016/s0140-6736(77)92775-1. [DOI] [PubMed] [Google Scholar]
  14. Wagner J. G. A safe method for rapidly achieving plasma concentration plateaus. Clin Pharmacol Ther. 1974 Oct;16(4):691–700. doi: 10.1002/cpt1974164691. [DOI] [PubMed] [Google Scholar]

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