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. 1983 Jan;49(1):26–29. doi: 10.1136/hrt.49.1.26

Alpha 1-antitrypsin in acute myocardial infarction.

H Gilutz, Y Siegel, E Paran, N Cristal, M R Quastel
PMCID: PMC485205  PMID: 6600394

Abstract

Alpha 1-antitrypsin serum levels were measured in 48 patients with acute myocardial infarction and in 19 control patients either with coronary heart disease without necrosis, or with neither coronary disease nor inflammation. Alpha 1-antitrypsin was significantly raised in the group of patients with acute myocardial infarction. As some patients individually showed no change in alpha 1-antitrypsin levels, however, they were divided into two groups according to the maximum serum levels attained. Patients with non-increasing levels of alpha 1-antitrypsin showed increased mortality and a higher incidence of cardiogenic shock, whereas reinfarction occurred more frequently in the group with high alpha 1-antitrypsin levels. Our findings may suggest that the course of a myocardial infarction is determined not only by the severity of the ischaemic event, but also by the response of the "acute" phase reaction" mechanism. We conclude that a failure of alpha 1-antitrypsin levels to increase after myocardial infarction may be associated with a worse clinical course.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Breit S. N., Penny R. The role of alpha 1 protease inhibitor (alpha 1 antitrypsin) in the regulation of immunologic and inflammatory reactions. Aust N Z J Med. 1980 Aug;10(4):449–453. doi: 10.1111/j.1445-5994.1980.tb04101.x. [DOI] [PubMed] [Google Scholar]
  2. Burgert W., Jr Alpha 1-antitrypsin deficiency. Postgrad Med. 1970 May;47(5):63–66. doi: 10.1080/00325481.1970.11697473. [DOI] [PubMed] [Google Scholar]
  3. Clarke H. G., Freeman T., Pryse-Phillips W. Serum protein changes after injury. Clin Sci. 1971 Apr;40(4):337–344. doi: 10.1042/cs0400337. [DOI] [PubMed] [Google Scholar]
  4. Cristal N., Peterburg I., Szwarcberg J. Atrial fibrillation developing in the acute phase of myocardial infarction. Prognostic implications. Chest. 1976 Jul;70(1):8–11. doi: 10.1378/chest.70.1.8. [DOI] [PubMed] [Google Scholar]
  5. Eaton L. W., Weiss J. L., Bulkley B. H., Garrison J. B., Weisfeldt M. L. Regional cardiac dilatation after acute myocardial infarction: recognition by two-dimensional echocardiography. N Engl J Med. 1979 Jan 11;300(2):57–62. doi: 10.1056/NEJM197901113000202. [DOI] [PubMed] [Google Scholar]
  6. Hutchins G. M., Bulkley B. H. Infarct expansion versus extension: two different complications of acute myocardial infarction. Am J Cardiol. 1978 Jun;41(7):1127–1132. doi: 10.1016/0002-9149(78)90869-x. [DOI] [PubMed] [Google Scholar]
  7. Lieberman J. Alpha 1 -antitrypsin deficiency. Med Clin North Am. 1973 May;57(3):691–706. doi: 10.1016/s0025-7125(16)32268-4. [DOI] [PubMed] [Google Scholar]
  8. Morse J. O. alpha1-antitrypsin deficiency (first of two parts). N Engl J Med. 1978 Nov 9;299(19):1045–1048. doi: 10.1056/NEJM197811092991905. [DOI] [PubMed] [Google Scholar]
  9. Neumann F., Meirom R., Rattner D., Trainin Z. Animal model of human disease. Alpha-antitrypsin deficiecy. Animal model: Round heart disease of turkeys. Am J Pathol. 1976 Aug;84(2):427–430. [PMC free article] [PubMed] [Google Scholar]
  10. Norris R. M., Brandt P. W., Caughey D. E., Lee A. J., Scott P. J. A new coronary prognostic index. Lancet. 1969 Feb 8;1(7589):274–278. doi: 10.1016/s0140-6736(69)91035-6. [DOI] [PubMed] [Google Scholar]
  11. Rennie J. A., Crawford G. P., Ogston D. Changes in protease inhibitors after acute myocardial infarction. J Clin Pathol. 1976 Jul;29(7):639–641. doi: 10.1136/jcp.29.7.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ritland S., Blomhoff J. P., Enger S. C., Skrede S., Gjone E. The esterification of cholesterol in plasma after acute myocardial infarction. Scand J Clin Lab Invest. 1975 Mar;35(2):181–187. [PubMed] [Google Scholar]
  13. Torp A. Myocardial biopsy in a case of cardiomyopathy and partial alpha-a antitrypsin deficiency with liver engagement. Acta Med Scand. 1975 Jan-Feb;197(1-2):137–140. doi: 10.1111/j.0954-6820.1975.tb04893.x. [DOI] [PubMed] [Google Scholar]
  14. Werner M. Serum protein changes during the acute phase reaction. Clin Chim Acta. 1969 Aug;25(2):299–305. doi: 10.1016/0009-8981(69)90272-1. [DOI] [PubMed] [Google Scholar]

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