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. 1983 Jan;49(1):90–93. doi: 10.1136/hrt.49.1.90

Effect of intravenous adrenaline on electrocardiogram, blood pressure, and serum potassium.

A D Struthers, J L Reid, R Whitesmith, J C Rodger
PMCID: PMC485215  PMID: 6821616

Abstract

Increased catecholamines after myocardial infarction may contribute to the development of arrhythmias. We have infused adrenaline intravenously in nine normal volunteers to levels similar to those seen after myocardial infarction. Adrenaline caused an increase in systolic blood pressure, a decrease in diastolic blood pressure, and an increase in heart rate. Adrenaline also produced a decrease in T wave amplitude and an increase in the QTc interval. The serum potassium fell dramatically during the adrenaline infusion from a control value of 4.06 mmol/l to 3.22 mmol/l. Hypokalaemia after myocardial infarction is associated with an increased incidence of ventricular arrhythmias. Thus, circulating adrenaline may increase the frequency of arrhythmias both directly via changes in ventricular repolarisation and indirectly via adrenaline induced hypokalaemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abildskov J. A. Adrenergic effects of the QT interval of the electrocardiogram. Am Heart J. 1976 Aug;92(2):210–216. doi: 10.1016/s0002-8703(76)80256-6. [DOI] [PubMed] [Google Scholar]
  2. Atterhög J. H., Eliasson K., Hjemdahl P. Sympathoadrenal and cardiovascular responses to mental stress, isometric handgrip, and cold pressor test in asymptomatic young men with primary T wave abnormalities in the electrocardiogram. Br Heart J. 1981 Sep;46(3):311–319. doi: 10.1136/hrt.46.3.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clausen T., Flatman J. A. Beta 2-adrenoceptors mediate the stimulating effect of adrenaline on active electrogenic Na-K-transport in rat soleus muscle. Br J Pharmacol. 1980 Apr;68(4):749–755. doi: 10.1111/j.1476-5381.1980.tb10868.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Corr P. B., Gillis R. A. Autonomic neural influences on the dysrhythmias resulting from myocardial infarction. Circ Res. 1978 Jul;43(1):1–9. doi: 10.1161/01.res.43.1.1. [DOI] [PubMed] [Google Scholar]
  5. D'Silva J. L. The action of adrenaline on serum potassium. J Physiol. 1934 Nov 12;82(4):393–398. doi: 10.1113/jphysiol.1934.sp003190. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Da Prada M., Zürcher Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci. 1976 Oct 15;19(8):1161–1174. doi: 10.1016/0024-3205(76)90251-4. [DOI] [PubMed] [Google Scholar]
  7. Doroghazi R. M., Childers R. Time-related changes in the Q-T interval in acute myocardial infarction: possible relation to local hypocalcemia. Am J Cardiol. 1978 Apr;41(4):684–688. doi: 10.1016/0002-9149(78)90818-4. [DOI] [PubMed] [Google Scholar]
  8. Dyckner T., Helmers C., Lundman T., Wester P. O. Initial serum potassium level in relation to early complications and prognosis in patients with acute myocardial infarction. Acta Med Scand. 1975 Mar;197(3):207–210. doi: 10.1111/j.0954-6820.1975.tb04903.x. [DOI] [PubMed] [Google Scholar]
  9. Grassi A. O., de Lew M. F., Cingolani H. E., Blesa E. S. Adrenergic beta blockade and changes in plasma potassium following epinephrine administration. Eur J Pharmacol. 1971 Jul;15(2):209–213. doi: 10.1016/0014-2999(71)90175-0. [DOI] [PubMed] [Google Scholar]
  10. Massara F., Tripodina A., Rotunno M. Propranolol block of epinephrine-induced hypokaliaemia in man. Eur J Pharmacol. 1970;10(3):404–407. doi: 10.1016/0014-2999(70)90214-1. [DOI] [PubMed] [Google Scholar]
  11. Taggart P., Donaldson R., Green J., Joseph S. P., Kelly H. B., Marcomichelakis J., Noble D., White J. Interrelation of heart rate and autonomic activity in asymptomatic men with unobstructed coronary arteries. Studies with atrial pacing, adrenaline infusion, and autonomic blockade. Br Heart J. 1982 Jan;47(1):19–25. doi: 10.1136/hrt.47.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Vetter N. J., Strange R. C., Adams W., Oliver M. F. Initial metabolic and hormonal response to acute myocardial infarction. Lancet. 1974 Feb 23;1(7852):284–288. doi: 10.1016/s0140-6736(74)92595-1. [DOI] [PubMed] [Google Scholar]
  13. Videbaek J., Christensen N. J., Sterndorff B. Serial determination of plasma catecholamines in myocardial infarction. Circulation. 1972 Nov;46(5):846–855. doi: 10.1161/01.cir.46.5.846. [DOI] [PubMed] [Google Scholar]
  14. Vincent G. M., Abildskov J. A., Burgess M. J. Q-T interval syndromes. Prog Cardiovasc Dis. 1974 May-Jun;16(6):523–530. doi: 10.1016/0033-0620(74)90016-4. [DOI] [PubMed] [Google Scholar]

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