Abstract
Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.
Footnotes
These authors contributed equally to the work.
Contributor Information
Guang-Hui Liu, Email: ghliu@ibp.ac.cn.
Weizhou Zhang, Email: weizhou-zhang@uiowa.edu.
Jing Qu, Email: jqu@moon.ibp.ac.cn.
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