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. 1990 Dec;53(12):1024–1028. doi: 10.1136/jnnp.53.12.1024

Life events and difficulties preceding stroke.

A House 1, M Dennis 1, L Mogridge 1, K Hawton 1, C Warlow 1
PMCID: PMC488307  PMID: 2292691

Abstract

Life events and difficulties were recorded for the year before stroke, using a standardised semi-structured interview, in 113 surviving patients seen after their first ever in a lifetime stroke. An age and sex-matched control group (n = 109) was also interviewed about the preceding year. The stroke patients reported fewer non-threatening events and events with only a short-term threat, while difficulties were reported with equal frequency by the two groups. However, events which were severely threatening in the long-term were significantly more common in the stroke patients (in the 52 weeks before stroke 26% versus 13%, odds ratio 2.3, 95% confidence interval 1.1-4.9). The increased rate was apparent throughout the year and not just in the weeks immediately before stroke onset. The number of stroke patients experiencing severe events in the follow up year fell to the level found in the control group. Recognised risk factors for stroke were found equally in those patients with and without severe events before onset, except that hypertension was rather less common in the patients who had experienced a severe event. It therefore appears that severe life events may be one of the determinants of stroke onset.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bamford J., Sandercock P., Dennis M., Warlow C., Jones L., McPherson K., Vessey M., Fowler G., Molyneux A., Hughes T. A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project 1981-86. 1. Methodology, demography and incident cases of first-ever stroke. J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1373–1380. doi: 10.1136/jnnp.51.11.1373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Carasso R., Yehuda S., Ben-Uriah Y. Personality type, life events and sudden cerebrovascular attack. Int J Neurosci. 1981;14(3-4):223–225. doi: 10.3109/00207458108985837. [DOI] [PubMed] [Google Scholar]
  3. Craig T. K., Brown G. W. Goal frustration and life events in the aetiology of painful gastrointestinal disorder. J Psychosom Res. 1984;28(5):411–421. doi: 10.1016/0022-3999(84)90073-4. [DOI] [PubMed] [Google Scholar]
  4. Creed F. Life events and appendicectomy. Lancet. 1981 Jun 27;1(8235):1381–1385. doi: 10.1016/s0140-6736(81)92567-8. [DOI] [PubMed] [Google Scholar]
  5. ECKER A. Emotional stress before strokes: a preliminary report of 20 cases. Ann Intern Med. 1954 Jan;40(1):49–56. doi: 10.7326/0003-4819-40-1-49. [DOI] [PubMed] [Google Scholar]
  6. Engel G. L. Sudden and rapid death during psychological stress. Folklore or folk wisdom? Ann Intern Med. 1971 May;74(5):771–782. doi: 10.7326/0003-4819-74-5-771. [DOI] [PubMed] [Google Scholar]
  7. Gentry W. D., Jenkins C. D., Kaplan B. H., Heyman A., Breslin M. S., Gianturco D. T. The A behavior pattern and ischemic cerebrovascular disease. Heart Lung. 1979 Nov-Dec;8(6):1113–1116. [PubMed] [Google Scholar]
  8. Grant I., Brown G. W., Harris T., McDonald W. I., Patterson T., Trimble M. R. Severely threatening events and marked life difficulties preceding onset or exacerbation of multiple sclerosis. J Neurol Neurosurg Psychiatry. 1989 Jan;52(1):8–13. doi: 10.1136/jnnp.52.1.8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Henry J. P. Mechanisms by which stress can lead to coronary heart disease. Postgrad Med J. 1986 Jul;62(729):687–693. doi: 10.1136/pgmj.62.729.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Levine S. P., Towell B. L., Suarez A. M., Knieriem L. K., Harris M. M., George J. N. Platelet activation and secretion associated with emotional stress. Circulation. 1985 Jun;71(6):1129–1134. doi: 10.1161/01.cir.71.6.1129. [DOI] [PubMed] [Google Scholar]
  11. Morris J. A., Gardner M. J. Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates. Br Med J (Clin Res Ed) 1988 May 7;296(6632):1313–1316. doi: 10.1136/bmj.296.6632.1313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Murphy E., Brown G. W. Life events, psychiatric disturbance and physical illness. Br J Psychiatry. 1980 Apr;136:326–338. doi: 10.1192/bjp.136.4.326. [DOI] [PubMed] [Google Scholar]
  13. Murphy E. Social origins of depression in old age. Br J Psychiatry. 1982 Aug;141:135–142. doi: 10.1192/bjp.141.2.135. [DOI] [PubMed] [Google Scholar]
  14. Penrose R. J. Life events before subarachnoid haemorrhage. J Psychosom Res. 1972 Aug;16(5):329–333. doi: 10.1016/0022-3999(72)90085-2. [DOI] [PubMed] [Google Scholar]
  15. Storey P. B. The precipitation of subarachnoid haemorrhage. J Psychosom Res. 1969 Jun;13(2):175–182. doi: 10.1016/0022-3999(69)90060-9. [DOI] [PubMed] [Google Scholar]
  16. Storey P. Emotional aspects of cerebrovascular disease. Adv Psychosom Med. 1985;13:71–84. doi: 10.1159/000411300. [DOI] [PubMed] [Google Scholar]

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