Abstract
Two patients are described who developed action, reflex myoclonus during acute renal failure. In both cases the myoclonus was abolished after the intravenous administration of clonazepam. We suggest that the characteristic action myoclonus, which occurs in both acute renal failure and postanoxic encephalopathy, is caused by a disturbance of function in the lower brainstem reticular formation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chadwick D., Hallett M., Harris R., Jenner P., Reynolds E. H., Marsden C. D. Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. Brain. 1977 Sep;100(3):455–487. doi: 10.1093/brain/100.3.455. [DOI] [PubMed] [Google Scholar]
- Hallett M., Chadwick D., Adam J., Marsden C. D. Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. J Neurol Neurosurg Psychiatry. 1977 Mar;40(3):253–264. doi: 10.1136/jnnp.40.3.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LANCE J. W., ADAMS R. D. The syndrome of intention or action myoclonus as a sequel to hypoxic encephalopathy. Brain. 1963 Mar;86:111–136. doi: 10.1093/brain/86.1.111. [DOI] [PubMed] [Google Scholar]
- LOCKE S., MERRILL J. P., TYLER H. R. Neurologic complications of acute uremia. Arch Intern Med. 1961 Oct;108:519–530. doi: 10.1001/archinte.1961.03620100011003. [DOI] [PubMed] [Google Scholar]
- Tyler H. R. Neurologic disorders in renal failure. Am J Med. 1968 May;44(5):734–748. doi: 10.1016/0002-9343(68)90255-6. [DOI] [PubMed] [Google Scholar]
- WOHLFART G., HOOK O. A clinical analysis of myoclonus epilepsy (Unverricht-Lundborg), myoclonic cerebellar dyssynergy (Hunt) and hepatolenticular degeneration (Wilson). Acta Psychiatr Neurol Scand. 1951;26(2):219–245. doi: 10.1111/j.1600-0447.1951.tb09671.x. [DOI] [PubMed] [Google Scholar]