Skip to main content
PMC home page
Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1980 Jun;43(6):516–521. doi: 10.1136/jnnp.43.6.516

Influenza A virus and Reye's syndrome in adults.

L E Davis, M Kornfeld
PMCID: PMC490592  PMID: 7205293

Abstract

We report fatal Reye's syndrome in two adults following proven influenza A viral infections. Reye's syndrome is, therefore, not confined to children but may also occur in adults. Many reported cases of postinfluenza A encephalopathy have clinical and pathological features of Reye's syndrome suggesting that they are not due to postinfectious perivenous demyelination.

Full text

PDF
518

Images in this article

517Image
on p.517
518Image
on p.518

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAMATTER F., GAUTIER A., JEANNERET O., PACCAUD M. F., WILDI E. [A case of influenza encephalitis with isolation of virus A/Asia/57 in the central nervous system]. Schweiz Med Wochenschr. 1961 May 13;91:567–571. [PubMed] [Google Scholar]
  2. BENNETT A. E., TURK R. E. Acute encephalitis and death following Asian influenza. Calif Med. 1957 Dec;87(6):411–412. [PMC free article] [PubMed] [Google Scholar]
  3. BESWICK I. P., FINLAYSON R. A renal lesion in association with influenza. J Clin Pathol. 1959 May;12(3):280–285. doi: 10.1136/jcp.12.3.280. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown R. E., Madge G. E. The choroid plexus in Reye's syndrome. Va Med Mon (1918) 1972 Mar;99(3):271–275. [PubMed] [Google Scholar]
  5. Brown T., Hug G., Lansky L., Bove K., Scheve A., Ryan M., Brown H., Schubert W. K., Partin J. C., Lloyd-Still J. Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome. N Engl J Med. 1976 Apr 15;294(16):861–867. doi: 10.1056/NEJM197604152941602. [DOI] [PubMed] [Google Scholar]
  6. Corey L., Rubin R. J., Bregman D., Gregg M. B. Diagnostic criteria for influenza B-associated Reye's syndrome: clinical vs. pathologic criteria. Pediatrics. 1977 Nov;60(5):702–708. [PubMed] [Google Scholar]
  7. Corey L., Rubin R. J., Hattwick M. A., Noble G. R., Cassidy E. A nationwide outbreak of Reye's Syndrome. Its epidemiologic relationship of influenza B. Am J Med. 1976 Nov;61(5):615–625. doi: 10.1016/0002-9343(76)90139-x. [DOI] [PubMed] [Google Scholar]
  8. Crandell R. A., Dowdle W. R., Holcomb T. M., Dahl E. V. A fatal illness associated with two viruses: an intermediate adenovirus type (21-16) and influenza A2. J Pediatr. 1968 Apr;72(4):467–473. doi: 10.1016/s0022-3476(68)80335-x. [DOI] [PubMed] [Google Scholar]
  9. FLEWETT T. H., HOULT J. G. Influenzal encephalopathy and postinfluenzal encephalitis. Lancet. 1958 Jul 5;2(7036):11–15. doi: 10.1016/s0140-6736(58)90003-5. [DOI] [PubMed] [Google Scholar]
  10. Finland M., Barnes M. W., Samper B. A. INFLUENZA VIRUS ISOLATIONS AND SEROLOGICAL STUDIES MADE IN BOSTON DURING THE WINTER OF 1943-1944. J Clin Invest. 1945 Mar;24(2):192–208. doi: 10.1172/JCI101597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Glick T. H., Ditchek N. T., Salitsky S., Freimuth E. J. Acute encephalopathy and hepatic dysfunctionassociated with chickenpox in siblings. Am J Dis Child. 1970 Jan;119(1):68–71. doi: 10.1001/archpedi.1970.02100050070016. [DOI] [PubMed] [Google Scholar]
  12. HORNER F. A. Neurologic disorders after Asian influenza. N Engl J Med. 1958 May 15;258(20):983–985. doi: 10.1056/NEJM195805152582004. [DOI] [PubMed] [Google Scholar]
  13. HORVATH S., BALAZS V. Ein Fall fataler asiatischer Influenza mit Encephalitissymptomen. Wien Klin Wochenschr. 1959 Apr 3;71(14):239–240. [PubMed] [Google Scholar]
  14. Hall B. D., Hughes W. T., Jr, Kmetz D. Reye's syndrome: an association with influenza A infection. J Ky Med Assoc. 1969 Apr;67(4):269–271. [PubMed] [Google Scholar]
  15. Harris H. B., Vogler L. B., Cassady G. Reye's syndrome in a neonate. South Med J. 1976 Nov;69(11):1511–1512. doi: 10.1097/00007611-197611000-00034. [DOI] [PubMed] [Google Scholar]
  16. Joshi V. V., Escobar M. R., Stewart L., Bates R. D. Fatal influenza A2 viral pneumonia in a newborn infant. Am J Dis Child. 1973 Dec;126(6):839–840. doi: 10.1001/archpedi.1973.02110190681021. [DOI] [PubMed] [Google Scholar]
  17. KAJI M., OSEASOHN R., JORDAN W. S., Jr, DINGLE J. H. Isolation of Asian virus from extrapulmonary tissues in fatal human influenza. Proc Soc Exp Biol Med. 1959 Feb;100(2):272–275. doi: 10.3181/00379727-100-24597. [DOI] [PubMed] [Google Scholar]
  18. KAPILA C. C., KAUL S., KAPUR S. C., KALAYANAM T. S., BANERJEE D. Neurological and hepatic disorders associated with influenza. Br Med J. 1958 Nov 29;2(5108):1311–1314. doi: 10.1136/bmj.2.5108.1311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Murphy A. M., Hawkes R. A. Neurological complications of influenza A2-Hong Kong-68 virus. Med J Aust. 1970 Sep 12;2(11):511–511. doi: 10.5694/j.1326-5377.1970.tb50147.x. [DOI] [PubMed] [Google Scholar]
  20. Nicholls S., Gill D., Craske J. Reye's syndrome associated with acute tubular necrosis. Arch Dis Child. 1975 Dec;50(12):960–962. doi: 10.1136/adc.50.12.960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. OSEASOHN R., ADELSON L., KAJI M. Clinicopathologic study of thirty-three fatal cases of Asian influenza. N Engl J Med. 1959 Mar 12;260(11):509–518. doi: 10.1056/NEJM195903122601101. [DOI] [PubMed] [Google Scholar]
  22. Ongerboer De Visser B. W., Dankmeijer H. F., Bots A. M., Endtz L. J. Hypothalamic polio-encephalitis in influenza A preceded by mononucleosis. J Neurol Sci. 1976 Sep;29(1):33–38. doi: 10.1016/0022-510x(76)90078-2. [DOI] [PubMed] [Google Scholar]
  23. Papageorgiou A., Wiglesworth F. W., Schiff D., Stern L. Reye's syndrome in a newborn infant. Can Med Assoc J. 1973 Oct 20;109(8):717–720. [PMC free article] [PubMed] [Google Scholar]
  24. REYE R. D., MORGAN G., BARAL J. ENCEPHALOPATHY AND FATTY DEGENERATION OF THE VISCERA. A DISEASE ENTITY IN CHILDHOOD. Lancet. 1963 Oct 12;2(7311):749–752. doi: 10.1016/s0140-6736(63)90554-3. [DOI] [PubMed] [Google Scholar]
  25. Ruben F. L., Michaels R. H. Reye syndrome with associated influenza A and B infection. JAMA. 1975 Oct 27;234(4):410–412. [PubMed] [Google Scholar]
  26. Thaler M. M. Pathogenesis of Reye's syndrome: A working hypothesis. Pediatrics. 1975 Dec;56(6):1081–1084. [PubMed] [Google Scholar]
  27. Varma R. R., Riedel D. R., Komorowski R. A., Harrington G. J., Nowak T. V. Reye's syndrome in nonpediatric age groups. JAMA. 1979 Sep 28;242(13):1373–1375. [PubMed] [Google Scholar]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Publishing Group

RESOURCES