Abstract
Twelve spastic patients received single oral doses of a new anti-spastic drug DS103-282 (Sandoz) 6 mg, baclofen 20 mg, and placebo on three separate days. Passive stretch responses were measured before administration and for four hours afterwards. DS103-282 was more effective than baclofen, and both drugs were more effective than placebo. Analysis of the recordings confirmed that DS103-282 had a specific effect upon stretch reflexes independent of its effect on resting muscle tone. Its action appeared at 30 to 45 minutes after ingestion, with maximum activity at 60-90 minutes. Unwanted effects of DS103-282 were drowsiness and (in one case) potentiation of antihypertensive therapy.
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- McLellan D. L., Selwyn M., Cooper I. S. Time course of clinical and physiological effects of stimulation of the cerebellar surface in patients with spasticity. J Neurol Neurosurg Psychiatry. 1978 Feb;41(2):150–160. doi: 10.1136/jnnp.41.2.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ringwald E., Campean S. J., Gerstenbrand F., Lorincz A., Lörincz P., Ludin H. P. Klinische Erfahrungen mit einem neuartigen Myotonolytikum (DS 103-282 Sandoz). Nervenarzt. 1977 Jul;48(7):355–358. [PubMed] [Google Scholar]
- Sayers A. C., Bürki H. R., Eichenberger E. The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (DS 103-282), a novel myotonolytic agent. Arzneimittelforschung. 1980;30(5):793–803. [PubMed] [Google Scholar]