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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Jan;44(1):86–89. doi: 10.1136/jnnp.44.1.86

Abnormalities of cerebrospinal fluid amino acids in patients with the Guillain-Barré syndrome.

R N Corston, E H McGale, C Stonier, G M Aber, E C Hutchinson
PMCID: PMC490825  PMID: 7205311

Abstract

Measurements of cerebrospinal fluid (CSF) and plasma amino acid concentrations have been made in 12 patients with the Guillain-Barré syndrome. The CSF protein concentration was normal in seven specimens and raised in 13. Abnormalities of the CSF amino acid profile were found in all specimens but were more marked in those with a raised CSF protein concentration. The possible causes and diagnostic significance of these changes are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asbury A. K., Arnason B. G., Adams R. D. The inflammatory lesion in idiopathic polyneuritis. Its role in pathogenesis. Medicine (Baltimore) 1969 May;48(3):173–215. doi: 10.1097/00005792-196905000-00001. [DOI] [PubMed] [Google Scholar]
  2. Atkins C. J., Kondon J. J., Quismorio F. P., Friou G. J. The choroid plexus in systemic lupus erythematosus. Ann Intern Med. 1972 Jan;76(1):65–72. doi: 10.7326/0003-4819-76-1-65. [DOI] [PubMed] [Google Scholar]
  3. Behan P. O., Lowenstein L. M., Stilmant M., Sax D. S. Landry-Guillain-Barré-Strohl syndrome and immune-complex nephritis. Lancet. 1973 Apr 21;1(7808):850–854. doi: 10.1016/s0140-6736(73)91420-7. [DOI] [PubMed] [Google Scholar]
  4. Corston R. N., McGale E. H., Stonier C., Hutchinson E. C., Aber G. M. Abnormalities of cerebrospinal fluid amino-acids in purulent meningitis. J Neurol Neurosurg Psychiatry. 1979 Oct;42(10):881–886. doi: 10.1136/jnnp.42.10.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cutler R. W., Lorenzo A. V. Transport of 1-aminocyclopentanecarboxylic acid from feline cerebrospinal fluid. Science. 1968 Sep 27;161(3848):1363–1364. doi: 10.1126/science.161.3848.1363. [DOI] [PubMed] [Google Scholar]
  6. Cutler R. W. Transport of lysine from cerebrospinal fluid of the cat. J Neurochem. 1970 Jul;17(7):1017–1027. doi: 10.1111/j.1471-4159.1970.tb02255.x. [DOI] [PubMed] [Google Scholar]
  7. Faber V., Balslov J. T. Immuno-fluorescent studies of renal biopsies in acute polyradiculitis. Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(5):655–656. doi: 10.1111/j.1699-0463.1970.tb04353.x. [DOI] [PubMed] [Google Scholar]
  8. Jensen K. Cerebrospinal fluid proteins in neurological diseases. Studies on agar gel electrophoresis protein profiles. Acta Neurol Scand Suppl. 1978;70:1–268. [PubMed] [Google Scholar]
  9. Kabat E. A., Moore D. H., Landow H. AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS. J Clin Invest. 1942 Sep;21(5):571–577. doi: 10.1172/JCI101335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Koss M. N., Chernack W. J., Griswold W. R., McIntosh R. M. The choroid plexus in acute serum sickness. Morpholgic, ultrastructural, and immunohistologic studies. Arch Pathol. 1973 Nov;96(5):331–334. [PubMed] [Google Scholar]
  11. Lakke J. P., Teelken A. W. Amino acid abnormalities in cerebrospinal fluid of patients with parkinsonism and extrapyramidal disorders. Neurology. 1976 May;26(5):489–493. doi: 10.1212/wnl.26.5.489. [DOI] [PubMed] [Google Scholar]
  12. Lampert P. W., Oldstone M. B. Host immunoglobulin G and complement deposits in the choroid plexus during spontaneous immune complex disease. Science. 1973 Apr 27;180(4084):408–410. doi: 10.1126/science.180.4084.408. [DOI] [PubMed] [Google Scholar]
  13. Lorenzo A. V., Cutler R. W. Amino acid transport by choroid plexus in vitro. J Neurochem. 1969 Apr;16(4):577–585. doi: 10.1111/j.1471-4159.1969.tb06857.x. [DOI] [PubMed] [Google Scholar]
  14. MELNICK S. C. Thirty-eight cases of the Guillain-Barre syndrome: an immunological study. Br Med J. 1963 Feb 9;1(5327):368–373. doi: 10.1136/bmj.1.5327.368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. McGale E. H., Pye I. F., Stonier C., Hutchinson E. C., Aber G. M. Studies of the inter-relationship between cerebrospinal fluid and plasma amino acid concentrations in normal individuals. J Neurochem. 1977 Aug;29(2):291–297. doi: 10.1111/j.1471-4159.1977.tb09621.x. [DOI] [PubMed] [Google Scholar]
  16. McIntosh R. M., Koss M. M. Editorial: The choroid plexus: immunologic injury and disease. Ann Intern Med. 1974 Jul;81(1):111–113. doi: 10.7326/0003-4819-81-1-111. [DOI] [PubMed] [Google Scholar]
  17. Miyazaki M., Fujita M., Genba H., Shimazaki K., Ogawa M. [Study on the blood-cerebrospinal fluid barrir (III). Permeability in the normal state and in polyradiculoneuritis]. Rinsho Shinkeigaku. 1975 Nov;15(11):843–850. [PubMed] [Google Scholar]
  18. Mutani R., Monaco F., Durelli L., Delsedime M. Free amino acids in the cerebrospinal fluid of epileptic subjects. Epilepsia. 1974 Dec;15(4):593–597. doi: 10.1111/j.1528-1157.1974.tb04031.x. [DOI] [PubMed] [Google Scholar]
  19. Pye I. F., Stonier C., McGale H. F. Double-enzymatic assay for determination of glutamine and glutamic acid in cerebrospinal fluid and plasma. Anal Chem. 1978 Jun;50(7):951–953. doi: 10.1021/ac50029a031. [DOI] [PubMed] [Google Scholar]
  20. Rieder H. P., Kaeser H. E., Nusselt L. Liquorproteinveränderungen bei Polyneuritis. Schweiz Med Wochenschr. 1972 Jun 3;102(22):766–772. [PubMed] [Google Scholar]
  21. Rodríguez-Iturbe B., García R., Rubio L., Zabala J., Moros G., Torres R. Acute glomerulonephritis in the Guillain-Barré-Strohl syndrome. Report of nine cases. Ann Intern Med. 1973 Mar;78(3):391–395. doi: 10.7326/0003-4819-78-3-391. [DOI] [PubMed] [Google Scholar]
  22. Schliep G., Felgenhauer K. Serum-CSF protein gradients, the blood-GSF barrier and the local immune response. J Neurol. 1978 May 18;218(2):77–96. doi: 10.1007/BF02402169. [DOI] [PubMed] [Google Scholar]
  23. Snodgrass S. R., Cutler R. W., Kang E. S., Lorenzo A. V. Transport of neutral amino acids from feline cerebrospinal fluid. Am J Physiol. 1969 Oct;217(4):974–980. doi: 10.1152/ajplegacy.1969.217.4.974. [DOI] [PubMed] [Google Scholar]
  24. Snodgrass S. R., Lorenzo A. V. Transport of GABA from the perfused ventricular system of the cat. J Neurochem. 1973 Mar;20(3):761–769. doi: 10.1111/j.1471-4159.1973.tb00037.x. [DOI] [PubMed] [Google Scholar]

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