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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1981 Jun;44(6):476–484. doi: 10.1136/jnnp.44.6.476

Improved estimates of conduction velocity distributions using single unit action potentials.

T E Milner, R B Stein, J Gillespie, B Hanley
PMCID: PMC491027  PMID: 7276960

Abstract

Single unit potentials were recorded from sural and medial gastrocnemius nerves. Action potential amplitude, integrated area and half-width (duration) were approximately proportional to conduction velocity, raised to the powers 1.5, 1 and -0.5 respectively with the sural nerve, and 2, 1.5 and -0.5 for the medial gastrocnemius nerve. These empirical relationships were applied to the computation of whole nerve conduction velocity distributions based on the relative number of single unit potentials of various conduction latencies required to reconstruct a recorded compound action potential. Conduction velocity distributions, which were converted to fibre diameter distributions, were in close agreement with the corresponding distributions determined histologically.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker A. T., Brown B. H., Freeston I. L. Determination of the distribution of conduction velocities in human nerve trunks. IEEE Trans Biomed Eng. 1979 Feb;26(2):76–81. doi: 10.1109/tbme.1979.326512. [DOI] [PubMed] [Google Scholar]
  2. Boyd I. A., Kalu K. U. Scaling factor relating conduction velocity and diameter for myelinated afferent nerve fibres in the cat hind limb. J Physiol. 1979 Apr;289:277–297. doi: 10.1113/jphysiol.1979.sp012737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cummins K. L., Dorfman L. J., Perkel D. H. Nerve fiber conduction-velocity distributions. II. Estimation based on two compound action potentials. Electroencephalogr Clin Neurophysiol. 1979 Jun;46(6):647–658. doi: 10.1016/0013-4694(79)90102-0. [DOI] [PubMed] [Google Scholar]
  4. Cummins K. L., Perkel D. H., Dorfman L. J. Nerve fiber conduction-velocity distributions. I. Estimation based on the single-fiber and compound action potentials. Electroencephalogr Clin Neurophysiol. 1979 Jun;46(6):634–646. doi: 10.1016/0013-4694(79)90101-9. [DOI] [PubMed] [Google Scholar]
  5. Kovacs Z. L., Johnson T. L., Sax D. S. Estimation of the distribution of conduction velocities in peripheral nerves. Comput Biol Med. 1979;9(4):281–293. doi: 10.1016/0010-4825(79)90035-0. [DOI] [PubMed] [Google Scholar]
  6. Landau W. M., Clare M. H., Bishop G. H. Reconstruction of myelinated nerve tract action potentials: an arithmetic method. Exp Neurol. 1968 Nov;22(3):480–490. doi: 10.1016/0014-4886(68)90012-5. [DOI] [PubMed] [Google Scholar]
  7. Lee R. G., Ashby P., White D. G., Aguayo A. J. Analysis of motor conduction velocity in the human median nerve by computer simulation of compound muscle action potentials. Electroencephalogr Clin Neurophysiol. 1975 Sep;39(3):225–237. doi: 10.1016/0013-4694(75)90144-3. [DOI] [PubMed] [Google Scholar]
  8. Milner T. E., Stein R. B. The effects of axotomy on the conduction of action potentials in peripheral sensory and motor nerve fibres. J Neurol Neurosurg Psychiatry. 1981 Jun;44(6):485–496. doi: 10.1136/jnnp.44.6.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Paintal A. S. The influence of diameter of medullated nerve fibres of cats on the rising and falling phases of the spike and its recovery. J Physiol. 1966 Jun;184(4):791–811. doi: 10.1113/jphysiol.1966.sp007948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Stein R. B., Nichols T. R., Jhamandas J., Davis L., Charles D. Stable long-term recordings from cat peripheral nerves. Brain Res. 1977 Jun 3;128(1):21–38. doi: 10.1016/0006-8993(77)90233-5. [DOI] [PubMed] [Google Scholar]
  11. Stein R. B., Pearson K. G. Predicted amplitude and form of action potentials recorded from unmyelinated nerve fibres. J Theor Biol. 1971 Sep;32(3):539–558. doi: 10.1016/0022-5193(71)90155-x. [DOI] [PubMed] [Google Scholar]

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