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. 1975 May;38(5):483–492. doi: 10.1136/jnnp.38.5.483

Contractility and supersensitivity to adrenaline in dystrophic muscle.

M Takamori
PMCID: PMC492001  PMID: 1151415

Abstract

In the adductor pollicis muscle of patients with limb-girdle and facioscapulohumeral muscular dystrophies and possible carriers of Duchenne type muscular dystrophy, abnormal active state properties were found at the time when there was no alteration of needle electromyography and evoked muscle action potentials. Adrenaline induced a marked reduction of incomplete tetanus via beta receptors without change in neuromuscular transmission.

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Selected References

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  1. BAKER N., WILSON L., OLDENDORF W., BLAHD W. H. Supersensitivity to neostigmine and resistance to d-tubocurarine in mice with hereditary myopathy. Am J Physiol. 1960 May;198:926–930. doi: 10.1152/ajplegacy.1960.198.5.926. [DOI] [PubMed] [Google Scholar]
  2. BOWMAN W. C., GOLDBERG A. A., RAPER C. A comparison between the effects of a tetanus and the effects of sympathomimetic amines on fast- and slow-contracting mammalian muscles. Br J Pharmacol Chemother. 1962 Dec;19:464–484. doi: 10.1111/j.1476-5381.1962.tb01451.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BOWMAN W. C., RAPER C. THE EFFECTS OF ADRENALINE AND OTHER DRUGS AFFECTING CARBOHYDRATE METABOLISM ON CONTRACTIONS OF THE RAT DIAPHRAGM. Br J Pharmacol Chemother. 1964 Aug;23:184–200. doi: 10.1111/j.1476-5381.1964.tb01578.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BOWMAN W. C., RAPER C. THE EFFECTS OF SYMPATHOMIMETIC AMINES ON CHRONICALLY DENERVATED SKELETAL MUSCLES. Br J Pharmacol Chemother. 1965 Feb;24:98–109. doi: 10.1111/j.1476-5381.1965.tb02083.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BROWN M. C., MATTHEWS P. B. The effect on a muscle twitch of the back-response of its motor nerve fibres. J Physiol. 1960 Feb;150:332–346. doi: 10.1113/jphysiol.1960.sp006391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BULLER A. J., LEWIS D. M. FURTHER OBSERVATIONS ON THE DIFFERENTIATION OF SKELETAL MUSCLES IN THE KITTEN HIND LIMB. J Physiol. 1965 Feb;176:355–370. doi: 10.1113/jphysiol.1965.sp007555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bowman W. C., Nott M. W. Actions of sympathomimetic amines and their antagonists on skeletal muscle. Pharmacol Rev. 1969 Mar;21(1):27–72. [PubMed] [Google Scholar]
  8. Bowman W. C., Raper C. Effects of sympathomimetic amines on neuromuscular transmission. Br J Pharmacol Chemother. 1966 Aug;27(2):313–331. doi: 10.1111/j.1476-5381.1966.tb01665.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CLOSE R. DYNAMIC PROPERTIES OF FAST AND SLOW SKELETAL MUSCLES OF THE RAT DURING DEVELOPMENT. J Physiol. 1964 Sep;173:74–95. doi: 10.1113/jphysiol.1964.sp007444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Close R. I. Dynamic properties of mammalian skeletal muscles. Physiol Rev. 1972 Jan;52(1):129–197. doi: 10.1152/physrev.1972.52.1.129. [DOI] [PubMed] [Google Scholar]
  11. Close R., Hoh J. F. The after-effects of repetitive stimulation on the isometric twitch contraction of rat fast skeletal muscle. J Physiol. 1968 Jul;197(2):461–477. doi: 10.1113/jphysiol.1968.sp008570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Desmedt J. E., Emeryk B. Disorder of muscle contraction processes in sex-linked (Duchenne) muscular dystrophy, with correlative electromyographic study of myopathic involvement in small hand muscles. Am J Med. 1968 Dec;45(6):853–872. doi: 10.1016/0002-9343(68)90184-8. [DOI] [PubMed] [Google Scholar]
  13. Desmedt J. E., Hainaut K. Kinetics of myofilament activation in potentiated contraction: staircase phenomenon in human skeletal muscle. Nature. 1968 Feb 10;217(5128):529–532. doi: 10.1038/217529a0. [DOI] [PubMed] [Google Scholar]
  14. Evans R. H., Smith J. W. Mode of action of catecholamines on skeletal muscle. J Physiol. 1973 Jul;232(2):81P–82P. [PubMed] [Google Scholar]
  15. Hinterbuchner L. P., Angyan A., Hirsch M. Effects of series of tetani on dystrophic and normal muscles of mouse. Am J Physiol. 1966 Oct;211(4):915–918. doi: 10.1152/ajplegacy.1966.211.4.915. [DOI] [PubMed] [Google Scholar]
  16. Howell J. N., Fairhurst A. S., Jenden D. J. Alterations of the calcium accumulating ability of striated muscle following denervation. Life Sci. 1966 Mar;5(5):439–446. doi: 10.1016/0024-3205(66)90159-7. [DOI] [PubMed] [Google Scholar]
  17. MACPHERSON L., WILKIE D. R. The duration of the active state in a muscle twitch. J Physiol. 1954 May 28;124(2):292–299. doi: 10.1113/jphysiol.1954.sp005107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MERTON P. A. Interaction between muscle fibres in a twitch. J Physiol. 1954 May 28;124(2):311–324. doi: 10.1113/jphysiol.1954.sp005110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Margreth A., Salviati G., Carraro U. Neural control on the activity of the calcium-transport system in sarcoplasmic reticulum of rat skeletal muscle. Nature. 1973 Jan 26;241(5387):285–286. doi: 10.1038/241285a0. [DOI] [PubMed] [Google Scholar]
  20. Marsden C. D., Meadows J. C. The effect of adrenaline on the contraction of human muscle. J Physiol. 1970 Apr;207(2):429–448. doi: 10.1113/jphysiol.1970.sp009071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. McComas A. J., Sica R. E., Upton A. R. Multiple muscle analysis of motor units in muscular dystrophy. Arch Neurol. 1974 Mar;30(3):249–251. doi: 10.1001/archneur.1974.00490330057009. [DOI] [PubMed] [Google Scholar]
  22. Mommaerts W. F., Buller A. J., Seraydarian K. The modification of some biochemical properties of muscle by cross-innervation. Proc Natl Acad Sci U S A. 1969 Sep;64(1):128–133. doi: 10.1073/pnas.64.1.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rasmussen H., Goodman D. B., Tenenhouse A. The role of cyclic AMP and calcium in cell activation. CRC Crit Rev Biochem. 1972 Feb;1(1):95–148. doi: 10.3109/10409237209102545. [DOI] [PubMed] [Google Scholar]
  24. Sandow A. Excitation-contraction coupling in skeletal muscle. Pharmacol Rev. 1965 Sep;17(3):265–320. [PubMed] [Google Scholar]
  25. Sandow A. Skeletal muscle. Annu Rev Physiol. 1970;32:87–138. doi: 10.1146/annurev.ph.32.030170.000511. [DOI] [PubMed] [Google Scholar]
  26. Sandow A., Taylor S. R., Preiser H. Role of the action potential in excitation-contraction coupling. Fed Proc. 1965 Sep-Oct;24(5):1116–1123. [PubMed] [Google Scholar]
  27. Slomić A., Rosenfalck A., Buchthal F. Electrical and mechanical responses of normal and myasthenic muscle. Brain Res. 1968 Aug 5;10(1):1–78. doi: 10.1016/0006-8993(68)90227-8. [DOI] [PubMed] [Google Scholar]
  28. Sreter F. A. Effect of denervation on fragmented sarcoplasmic reticulum of white and red muscle. Exp Neurol. 1970 Oct;29(1):52–64. doi: 10.1016/0014-4886(70)90036-1. [DOI] [PubMed] [Google Scholar]
  29. Sullivan A., Zaimis E. The effect of isoprenaline on cyclic AMP concentrations in skeletal muscle. J Physiol. 1973 Jun;231(2):102P–103P. [PubMed] [Google Scholar]
  30. Takamori M. Caffeine, calcium, and Eaton-Lambert syndrome. Arch Neurol. 1972 Oct;27(4):285–291. doi: 10.1001/archneur.1972.00490160013002. [DOI] [PubMed] [Google Scholar]
  31. Takamori M., Gutmann L., Crosby T. W., Martin J. D. Myasthenic syndromes in hypothyroidism. Electrophysiological study of neuromuscular transmission and muscle contraction in two patients. Arch Neurol. 1972 Apr;26(4):326–335. doi: 10.1001/archneur.1972.00490100056005. [DOI] [PubMed] [Google Scholar]
  32. Takamori M., Gutmann L., Shane S. R. Contractile properties of human skeletal muscle. Normal and thyroid disease. Arch Neurol. 1971 Dec;25(6):535–546. doi: 10.1001/archneur.1971.00490060069007. [DOI] [PubMed] [Google Scholar]
  33. Takamori M., Ishii N., Mori M. The role of cyclic 3',5'-adenosine monophosphate in neuromuscular transmission. Arch Neurol. 1973 Dec;29(6):420–424. doi: 10.1001/archneur.1973.00490300082011. [DOI] [PubMed] [Google Scholar]
  34. Tashiro N. Effects of isoprenaline on contractions of directly stimulated fast and slow skeletal muscles of the guinea-pig. Br J Pharmacol. 1973 May;48(1):121–131. doi: 10.1111/j.1476-5381.1973.tb08229.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Taylor S. R., Preiser H., Sandow A. Mechanical threshold as a factor in excitation-contraction coupling. J Gen Physiol. 1969 Sep;54(3):352–368. doi: 10.1085/jgp.54.3.352. [DOI] [PMC free article] [PubMed] [Google Scholar]

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