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. 1992 Jun 1;89(11):4928–4932. doi: 10.1073/pnas.89.11.4928

Proteasomes are regulated by interferon gamma: implications for antigen processing.

Y Yang 1, J B Waters 1, K Früh 1, P A Peterson 1
PMCID: PMC49201  PMID: 1594596

Abstract

Class I major histocompatibility complex (MHC) molecules present antigenic peptides of cytoplasmic origin to T cells. As the lengths of these peptides seem restricted to eight or nine amino acids, an unusual proteolytic system must play a role in antigen processing. Proteasomes, a major extralysosomal proteolytic system, are responsible for the degradation of cytoplasmic proteins. We demonstrate that several proteasomal subunits, including MHC-encoded subunits, are regulated by interferon gamma. These data and the finding that MHC-encoded and other interferon gamma-regulated proteasomal subunits are uniquely associated with proteasomes strongly suggest that the immune system has recruited proteasomes for antigen processing.

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