Abstract
Twenty-seven cases diagnosed as having malignant melanoma affecting the central nervous system have been studied. In 20 patients the tumours represented secondary spread from elsewhere, but there were six who had a primary melanoma either of the spinal cord, leptomeninges, or brain. Confusion exists in the literature about how to differentiate primary from secondary tumours but this suggests several clinical factors which may indicate that the lesion is probably a primary one. This method of categorizing the cases is supported by the differences in duration of symptoms and survival times for each group and a simple classification can therefore be proposed.
Full text
PDF![526](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b6/492341/3edd5e134e1f/jnnpsyc00168-0012.png)
![527](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b6/492341/228bc619ec37/jnnpsyc00168-0013.png)
![528](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b6/492341/6f47de000d29/jnnpsyc00168-0014.png)
![529](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b6/492341/85fb39da1f60/jnnpsyc00168-0015.png)
![530](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68b6/492341/5c5be2123f1e/jnnpsyc00168-0016.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HIRANO A., CARTON C. A. Primary malignant melanoma of the spinal cord. J Neurosurg. 1960 Nov;17:935–944. doi: 10.3171/jns.1960.17.6.0935. [DOI] [PubMed] [Google Scholar]
- NEILSON J. M., MOFFAT A. D. Hypopituitarism caused by a melanoma of the pituitary gland. J Clin Pathol. 1963 Mar;16:144–149. doi: 10.1136/jcp.16.2.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PAPPENHEIM E., BHATTACHARJI S. K. Primary melanoma of the central nervous system. Clinical-pathological report of a case, with survey and discussion of the literature. Arch Neurol. 1962 Aug;7:101–113. doi: 10.1001/archneur.1962.04210020023003. [DOI] [PubMed] [Google Scholar]
- RICHARDS P., McKISSOCK W. Intracranial metastases. Br Med J. 1963 Jan 5;1(5322):15–18. doi: 10.1136/bmj.1.5322.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Salm R. Primary malignant melanoma of the cerebellum. J Pathol Bacteriol. 1967 Jul;94(1):196–200. doi: 10.1002/path.1700940126. [DOI] [PubMed] [Google Scholar]