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. 1976 Jul;39(7):656–662. doi: 10.1136/jnnp.39.7.656

Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.

C D Frith, E C Johnston, M H Joseph, R J Powell, R W Watts
PMCID: PMC492397  PMID: 792398

Abstract

5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.

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Selected References

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