Abstract
The value of CSF enzyme estimations as indices of the extent of brain damage was studied in the experimental situation. Standard cold lesions of different severity were induced in cats. The activities of the enzymes CPK, HBDH, LDH, GOT, AND ChE were studied at half hour intervals in the cerebrospinal fluid (CSF). The ventricular and cisternal fluid pressure, and the arterial blood pressure were monitored continuously. Significantly higher enzyme levels were found in the animals with more severe injuries of the brain.
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Selected References
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- CLASEN R. A., COOKE P. M., PANDOLFIS, BOYD D., RAIMONDI A. J. Experimental cerebral edema produced by focal freezing. 1. An anatomic study utilizing vital dye techniques. J Neuropathol Exp Neurol. 1962 Oct;21:579–596. doi: 10.1097/00005072-196210000-00006. [DOI] [PubMed] [Google Scholar]
- Dubo H., Park D. C., Pennington R. J., Kalbag R. M., Walton J. N. Serum-creatine-kinase in cases of stroke, head injury, and meningitis. Lancet. 1967 Oct 7;2(7519):743–748. doi: 10.1016/s0140-6736(67)91946-0. [DOI] [PubMed] [Google Scholar]
- Go K. G., Ebels E. J., Beks J. W., ter Weeme C. A. The spreading of cerebral edema from a cold injury in cats. Psychiatr Neurol Neurochir. 1967 Sep-Oct;70(5):403–411. [PubMed] [Google Scholar]
- Jennett B. Prognosis after severe head injury. Clin Neurosurg. 1972;19:200–207. doi: 10.1093/neurosurgery/19.cn_suppl_1.200. [DOI] [PubMed] [Google Scholar]
- KLATZO I., PIRAUX A., LASKOWSKI E. J. The relationship between edema, blood-brain-barrier and tissue elements in a local brain injury. J Neuropathol Exp Neurol. 1958 Oct;17(4):548–564. doi: 10.1097/00005072-195810000-00002. [DOI] [PubMed] [Google Scholar]
- Kaltiala E. H., Heikkinen E. S., Kärki N. T., Larmi T. K. Cerebrospinal fluid and serum transaminases and lactic dehydrogenase after head injury. Acta Neurol Scand. 1968;44(1):124–129. doi: 10.1111/j.1600-0404.1968.tb07449.x. [DOI] [PubMed] [Google Scholar]
- Klun B. Spinal fluid and blood serum enzyme activity in brain injuries. J Neurosurg. 1974 Aug;41(2):224–228. doi: 10.3171/jns.1974.41.2.0224. [DOI] [PubMed] [Google Scholar]
- Lindblom U., Aberg B. The pattern of S-LDH isoenzymes and S-GOT after traumatic brain injury. Scand J Rehabil Med. 1972;4(2):61–72. [PubMed] [Google Scholar]
- Maas A. I. Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury. J Neurol Neurosurg Psychiatry. 1977 Jul;40(7):655–665. doi: 10.1136/jnnp.40.7.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rabow L., Hebbe B., Liedén G. Enzyme analysis for evaluating acute head injury. Acta Chir Scand. 1971;137(4):305–309. [PubMed] [Google Scholar]
- Rabow L. Iso-enzyme of lactic dehydrogenase as a prognosticon in patients with contusio cerebri. Scand J Rehabil Med. 1972;4(2):90–92. [PubMed] [Google Scholar]
- SMITH S. E., CAMMACK K. V., DODDS M. E., CURRY G. J. Glutamic-oxalacetic transaminase in the evaluation of acute injury to the head. Am J Surg. 1960 May;99:713–716. doi: 10.1016/0002-9610(60)90019-2. [DOI] [PubMed] [Google Scholar]
- Thomas D. G., Rowan T. D. Lactic dehydrogenase isoenzymes following head injury. Injury. 1976 May;7(4):258–262. doi: 10.1016/s0020-1383(75)80003-9. [DOI] [PubMed] [Google Scholar]
- WAKIM K. G., FLEISHER G. A. The effect of experimental cerebral infarction on transaminase activity in serum, cerebrospinal fluid and infarcted tissue. Proc Staff Meet Mayo Clin. 1956 Jun 27;31(13):391–399. [PubMed] [Google Scholar]