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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1977 Oct;40(10):967–969. doi: 10.1136/jnnp.40.10.967

Measurement of prostaglandin E2 in cerebrospinal fluid in patients suffering from stroke.

R L Carasso, J Vardi, J M Rabay, U Zor, M Streifler
PMCID: PMC492877  PMID: 591974

Abstract

In 16 patients suffering from cerebrovascular events, prostaglandin (PG) E2 was measured in their cerebrospinal fluid and correlated with their clinical status and evolution. Prostaglandin E2 ranged from 200-3000 pg (picogram)/ml of cerebrospinal fluid. A positive correlation was found between PG E2 levels and the severity and clinical outcome of the stroke.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauminger S., Zor U., Lindner H. R. Radioimmunological assay of prostaglandin synthetase activity. Prostaglandins. 1973 Sep;4(3):313–324. doi: 10.1016/0090-6980(73)90019-1. [DOI] [PubMed] [Google Scholar]
  2. Bito L. Z. Accumulation and apparent active transport of prostaglandins by some rabbit tissues in vitro. J Physiol. 1972 Mar;221(2):371–387. doi: 10.1113/jphysiol.1972.sp009756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bito L. Z. Comparative study of concentrative prostaglandin accumulation by various tissues of mammals and marine vertebrates and invertebrates. Comp Biochem Physiol A Comp Physiol. 1972 Sep 1;43(1):65–82. doi: 10.1016/0300-9629(72)90470-7. [DOI] [PubMed] [Google Scholar]
  4. Denton I. C., Jr, White R. P., Robertson J. T. The effects of prostaglandins E 1 , A 1 , and F 2a on the cerebral circulation of dogs and monkeys. J Neurosurg. 1972 Jan;36(1):34–42. doi: 10.3171/jns.1972.36.1.0034. [DOI] [PubMed] [Google Scholar]
  5. Greenberg S., Wilson W. R., Howard L. Mechanism of the vasoconstrictor action of prostaglandin B. J Pharmacol Exp Ther. 1974 Jul;190(1):59–69. [PubMed] [Google Scholar]
  6. Hoedt-Rasmussen K., Skinhoj E., Paulson O., Ewald J., Bjerrum J. K., Fahrenkrug A., Lassen N. A. Regional cerebral blood flow in acute apoplexy. The "luxury perfusion syndrome" of brain tissue. Arch Neurol. 1967 Sep;17(3):271–281. doi: 10.1001/archneur.1967.00470270049007. [DOI] [PubMed] [Google Scholar]
  7. Holmes S. W., Horton E. W. The identification of four prostaglandins in dog brain and their regional distribution in the central nervous system. J Physiol. 1968 Apr;195(3):731–741. doi: 10.1113/jphysiol.1968.sp008485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. La Torre E., Patrono C., Fortuna A., Grossi-Belloni D. Role of prostaglandin F2 in human cerebral vasospasm. J Neurosurg. 1974 Sep;41(3):293–299. doi: 10.3171/jns.1974.41.3.0293. [DOI] [PubMed] [Google Scholar]
  9. Lavyne M. H., Moskowitz M. A., Larin F., Zervas N. T., Wurtman R. J. Brain H-3-catecholamine metabolism in experimental cerebral ischemia. Neurology. 1975 May;25(5):483–485. doi: 10.1212/wnl.25.5.483. [DOI] [PubMed] [Google Scholar]
  10. Nakano J., Chang A. C., Fisher R. G. Effects of prostaglandins E 1 , E 2 , A 1 , A 2 , and F 2 on canine carotid arterial blood flow, cerebrospinal fluid pressure, and intraocular pressure. J Neurosurg. 1973 Jan;38(1):32–39. doi: 10.3171/jns.1973.38.1.0032. [DOI] [PubMed] [Google Scholar]
  11. Nakano J., Prancan A. V., Moore S. E. Metabolism of prostaglandin E 1 in the cerebral cortex and cerebellum of the dog and rat. Brain Res. 1972 Apr 28;39(2):545–548. doi: 10.1016/0006-8993(72)90462-3. [DOI] [PubMed] [Google Scholar]
  12. Paulson O. B., Lassen N. A., Skinhoj E. Regional cerebral blood flow in apoplexy without arterial occlusion. Neurology. 1970 Feb;20(2):125–138. doi: 10.1212/wnl.20.2.125. [DOI] [PubMed] [Google Scholar]
  13. Pelofsky S., Jacobson E. D., Fisher R. G. Effects of prostaglandin E 1 on experimental cerebral vasospasm. J Neurosurg. 1972 May;36(5):634–639. doi: 10.3171/jns.1972.36.5.0634. [DOI] [PubMed] [Google Scholar]
  14. Pennink M., White R. P., Crockarell J. R., Robertson J. T. Role of prostaglandin F 2 in the genesis of experimental cerebral vasospasm. Angiographic study in dogs. J Neurosurg. 1972 Oct;37(4):398–406. doi: 10.3171/jns.1972.37.4.0398. [DOI] [PubMed] [Google Scholar]
  15. White R. P., Heaton J. A., Denton I. C. Pharmacological comparison of prostaglandin F 2a' serotonin and norepinephrine on cerebrovascular tone of monkey. Eur J Pharmacol. 1971;15(3):300–309. doi: 10.1016/0014-2999(71)90096-3. [DOI] [PubMed] [Google Scholar]
  16. Wurtman R. J., Zervas N. T. Monoamine neurotransmitters and the pathophysiology of stroke and central nervous system trauma. J Neurosurg. 1974 Jan;40(1):34–36. doi: 10.3171/jns.1974.40.1.0034. [DOI] [PubMed] [Google Scholar]
  17. Yamamoto Y. L., Feindel W., Wolfe L. S., Katoh H., Hodge C. P. Experimental vasoconstriction of cerebral arteries by prostaglandins. J Neurosurg. 1972 Oct;37(4):385–397. doi: 10.3171/jns.1972.37.4.0385. [DOI] [PubMed] [Google Scholar]

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