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. 1978 May;41(5):404–407. doi: 10.1136/jnnp.41.5.404

Therapeutic trials in muscular dystrophy. 1. Gold in murine dystrophy.

A Enomoto, W G Bradley
PMCID: PMC493045  PMID: 96218

Abstract

A trial of sodium aurothiomalate as an antiproteinase drug in the treatment of murine muscular dystrophy is reported. A blind controlled comparison of high (25 microgram/10 g body weight) and low dose gold (5 microgram/10 g body weight) with saline-injected control animals was made, all injections being given three times weekly. The body weights and functional ability of the mice were assessed at weekly intervals. No significant difference between the groups was observed. A trial of very high dose chrysotherapy (500 microgram of gold/10 g body weight) also showed no therapeutic benefit.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ennis R. S., Granda J. L., Posner A. S. Effect of gold salts and other drugs on the release and activity of lysosomal hydrolases. Arthritis Rheum. 1968 Dec;11(6):756–764. doi: 10.1002/art.1780110605. [DOI] [PubMed] [Google Scholar]
  2. Enomoto A., Bradley W. G. Therapeutic trials in muscular dystrophy. III. Studies of microbial proteinase inhibitors in murine dystrophy. Arch Neurol. 1977 Dec;34(12):771–773. doi: 10.1001/archneur.1977.00500240059010. [DOI] [PubMed] [Google Scholar]
  3. Enomoto A., Bradley W. G. Therapeutic trials in muscular dystrophy: II. Ethylene and its derivatives. Ann Neurol. 1977 Oct;2(4):267–270. doi: 10.1002/ana.410020402. [DOI] [PubMed] [Google Scholar]
  4. Gerber R. C., Paulus H. E., Jennrich R. I., Lederer M., Bluestone R., Blahd W. H., Pearson C. M. Gold kinetics following aurothiomalate therapy: use of a whole-body radiation counter. J Lab Clin Med. 1974 May;83(5):778–789. [PubMed] [Google Scholar]
  5. Gottlieb N. L., Smith P. M., Smith E. M. Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy. Arthritis Rheum. 1972 Jan-Feb;15(1):16–22. doi: 10.1002/art.1780150103. [DOI] [PubMed] [Google Scholar]
  6. JEFFREY M. R., FREUNDLICH H. F., BALLEY D. M. Distribution and excretion of radiogold in animals. Ann Rheum Dis. 1958 Mar;17(1):52–60. doi: 10.1136/ard.17.1.52. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Janoff A. Inhibition of human granulocyte elastase by gold sodium thiomalate. Biochem Pharmacol. 1970 Feb;19(2):626–628. doi: 10.1016/0006-2952(70)90222-4. [DOI] [PubMed] [Google Scholar]
  8. Jessop J. D., Vernon-Roberts B., Harris J. Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exudates studied by a "skin-window" technique in rheumatoid and control patients. Ann Rheum Dis. 1973 Jul;32(4):294–300. doi: 10.1136/ard.32.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kar N. C., Pearson C. M. Acid, neutral and alkaline cathepsins in normal and diseased human muscle. Enzyme. 1972;13(4):188–196. doi: 10.1159/000459660. [DOI] [PubMed] [Google Scholar]
  10. LOCKIE L. M., NORCROSS B. M., RIORDAN D. J. Gold in the treatment of rheumatoid arthritis. J Am Med Assoc. 1958 Jul 5;167(10):1204–1207. doi: 10.1001/jama.1958.02990270010003. [DOI] [PubMed] [Google Scholar]
  11. Mascarenhas B. R., Granda J. L., Freyberg R. H. Gold metabolism in patients with rheumatoid arthritis treated with gold compounds--reinvestigated. Arthritis Rheum. 1972 Jul-Aug;15(4):391–402. doi: 10.1002/art.1780150410. [DOI] [PubMed] [Google Scholar]
  12. McGowan E. B., Shafiq S. A., Stracher A. Delayed degeneration of dystrophic and normal muscle cell cultures treated with pepstatin, leupeptin, and antipain. Exp Neurol. 1976 Mar;50(3):649–657. doi: 10.1016/0014-4886(76)90034-0. [DOI] [PubMed] [Google Scholar]
  13. McQueen E. G., Dykes P. W. Transport of gold in the body. Ann Rheum Dis. 1969 Jul;28(4):437–442. doi: 10.1136/ard.28.4.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pennington R. J. Biochemistry of dystrophic muscle. 2. Some enzyme changes in dystrophic mouse muscle. Biochem J. 1963 Jul;88(1):64–68. doi: 10.1042/bj0880064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Persellin R. H., Ziff M. The effect of gold salt on lysosomal enzymes of the peritoneal macrophage. Arthritis Rheum. 1966 Feb;9(1):57–65. doi: 10.1002/art.1780090107. [DOI] [PubMed] [Google Scholar]
  16. SMITH R. T., PEAK W. P., KRON K. M., HERMANN I. F., DELTORO R. A., GOLDMAN M. Increasing the effectiveness of gold therapy in rheumatoid arthritis. J Am Med Assoc. 1958 Jul 5;167(10):1197–1204. doi: 10.1001/jama.1958.02990270003002. [DOI] [PubMed] [Google Scholar]
  17. TAPPEL A. L., ZALKIN H., CALDWELL K. A., DESAI I. D., SHIBKO S. Increased lysosomal enzymes in genetic muscular dystrophy. Arch Biochem Biophys. 1962 Feb;96:340–346. doi: 10.1016/0003-9861(62)90418-6. [DOI] [PubMed] [Google Scholar]
  18. Vernon-Roberts B., Jessop J. D., Doré J. Effects of gold salts and prednisolone on inflammatory cells. II. Suppression of inflammation and phagocytosis in the rat. Ann Rheum Dis. 1973 Jul;32(4):301–307. doi: 10.1136/ard.32.4.301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. WEINSTOCK I. M., EPSTEIN S., MILHORAT A. T. Enzyme studies in muscular dystrophy. III. In hereditary muscular dystrophy in mice. Proc Soc Exp Biol Med. 1958 Oct;99(1):272–276. doi: 10.3181/00379727-99-24320. [DOI] [PubMed] [Google Scholar]
  20. Yarom R., Behar A. J., Yanko L., Hall T. A., Peters P. D. Gold tracer studies of muscle regeneration. J Neuropathol Exp Neurol. 1976 Jul;35(4):445–457. doi: 10.1097/00005072-197607000-00005. [DOI] [PubMed] [Google Scholar]

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