Abstract
The finding of virus particles by transmission electron microscopy (TEM) in fixed cervical and vaginal scrape material and their identification as papilloma viruses by negative staining is described. The colposcopic, cytological, and histological appearances in a group of 10 patients in whom virus particles were seen are discussed and the possibly considered of an association between papilloma virus infection and the development of cervical intraepithelial neoplasia (CIN) and multifocal intraepithelial neoplasia of the female lower genital tract.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALMEIDA J. D., HOWATSON A. F., WILLIAMS M. G. Electron microscope study of human warts; sites of virus production and nature of the inclusion bodies. J Invest Dermatol. 1962 Jun;38:337–345. [PubMed] [Google Scholar]
- Buscema J., Woodruff J. D., Parmley T. H., Genadry R. Carcinoma in situ of the vulva. Obstet Gynecol. 1980 Feb;55(2):225–230. [PubMed] [Google Scholar]
- Della Torre G., Pilotti S., de Palo G., Rilke F. Viral particles in cervical condylomatous lesions. Tumori. 1978 Oct 31;64(5):549–553. doi: 10.1177/030089167806400513. [DOI] [PubMed] [Google Scholar]
- Franklin E. W., 3rd, Rutledge F. D. Epidemiology of epidermoid carcinoma of the vulva. Obstet Gynecol. 1972 Feb;39(2):165–172. [PubMed] [Google Scholar]
- Hansen L. H., Collins C. G. Multicentric squamous cell carcinomas of the lower female genital tract. Eleven cases with epidermoid carcinoma of both vulva and cervix. Am J Obstet Gynecol. 1967 Aug 1;98(7):982–986. doi: 10.1016/0002-9378(67)90085-3. [DOI] [PubMed] [Google Scholar]
- Hills E., Laverty C. R. Electron microscopic detection of papilloma virus particles in selected koilocytotic cells in a routine cervical smear. Acta Cytol. 1979 Jan-Feb;23(1):53–56. [PubMed] [Google Scholar]
- Josey W. E., Nahmias A. J., Naib Z. M. Viruses and cancer of the lower genital tract. Cancer. 1976 Jul;38(1 Suppl):526–533. doi: 10.1002/1097-0142(197607)38:1<526::aid-cncr2820380176>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
- Laverty C. R., Booth N., Hills E., Cossart Y., Wills E. J. Noncondylomatous wart virus infection of the postmenopausal cervix. Pathology. 1978 Oct;10(4):373–378. doi: 10.3109/00313027809063526. [DOI] [PubMed] [Google Scholar]
- Laverty C. R., Russell P., Hills E., Booth N. The significance of noncondylomatous wart virus infection of the cervical transformation zone. A review with discussion of two illustrative cases. Acta Cytol. 1978 Jul-Aug;22(4):195–201. [PubMed] [Google Scholar]
- Leckie G. B., Cotton R. E. Simultaneous in situ carcinoma of the cervix, vulva and perineum after immunosuppressive therapy for renal transplantation. Br J Obstet Gynaecol. 1977 Feb;84(2):143–148. doi: 10.1111/j.1471-0528.1977.tb12543.x. [DOI] [PubMed] [Google Scholar]
- Meisels A., Fortin R. Condylomatous lesions of the cervix and vagina. I. Cytologic patterns. Acta Cytol. 1976 Nov-Dec;20(6):505–509. [PubMed] [Google Scholar]
- Meisels A., Fortin R., Roy M. Condylomatous lesions of the cervix. II. Cytologic, colposcopic and histopathologic study. Acta Cytol. 1977 May-Jun;21(3):379–390. [PubMed] [Google Scholar]
- Mickal A., Andonie J. A., Dougherty C. M. Squamous cell carcinoma of the vulva. Obstet Gynecol. 1966 Nov;28(5):670–674. [PubMed] [Google Scholar]
- Oriel J. D., Almeida J. D. Demonstration of virus particles in human genital warts. Br J Vener Dis. 1970 Feb;46(1):37–42. doi: 10.1136/sti.46.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Purola E., Savia E. Cytology of gynecologic condyloma acuminatum. Acta Cytol. 1977 Jan-Feb;21(1):26–31. [PubMed] [Google Scholar]
- Stanbridge D. M., Butler E. B., Langley F. A. Problems in cervicovaginal cytology: fine structure as an aid to diagnosis. Acta Cytol. 1980 Jul-Aug;24(4):335–343. [PubMed] [Google Scholar]
- Syrjänen K. J. Morphologic survey of the condylomatous lesions in dysplastic and neoplastic epithelium of the uterine cervix. Arch Gynecol. 1979 Aug;227(2):153–161. doi: 10.1007/BF02103290. [DOI] [PubMed] [Google Scholar]
- Woodruff J. D., Braun L., Cavalieri R., Gupta P., Pass F., Shah K. V. Immunologic identification of papillomavirus antigen in condyloma tissues from the female genital tract. Obstet Gynecol. 1980 Dec;56(6):727–732. [PubMed] [Google Scholar]
- Woodruff J. D., Davis H. J., Jones H. J., Jr, Recio R. G., Salimi R., Park I. J. Correlated investigative technics of multiple anaplasias in the lower genital canal. Obstet Gynecol. 1969 May;33(5):609–616. [PubMed] [Google Scholar]