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. 1970 Jun;33(3):319–329. doi: 10.1136/jnnp.33.3.319

Mapping of motor units in experimentally reinnervated rat muscle

Interpretation of histochemical and atrophic fibre patterns in neurogenic lesions

Eric Kugelberg 1, Lars Edström 1, Michele Abbruzzese 1,1
PMCID: PMC493476  PMID: 4246999

Abstract

The distribution of fibres in the motor units of reinnervated muscle is demonstrated. As shown in some experimental models, the histochemical and atrophic fibre patterns in neurogenic lesions are determined by the morphology of the specific motor units involved. This also helps to explain the alterations of motor unit action currents in neurogenic lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAJUSZ E. "RED" SKELETAL MUSCLE FIBERS: RELATIVE INDEPENDENCE OF NEURAL CONTROL. Science. 1964 Aug 28;145(3635):938–939. doi: 10.1126/science.145.3635.938. [DOI] [PubMed] [Google Scholar]
  2. Dubowitz V. Pathology of experimentally re-innervated skeletal muscle. J Neurol Neurosurg Psychiatry. 1967 Apr;30(2):99–110. doi: 10.1136/jnnp.30.2.99. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. EDDS M. V., Jr Collateral nerve regeneration. Q Rev Biol. 1953 Sep;28(3):260–276. doi: 10.1086/399699. [DOI] [PubMed] [Google Scholar]
  4. ERMINIO F., BUCHTHAL F., ROSENFALCK P. Motor unit territory and muscle fiber concentration in paresis due to peripheral nerve injury and anterior horn cell involvement. Neurology. 1959 Oct;9:657–671. doi: 10.1212/wnl.9.10.657. [DOI] [PubMed] [Google Scholar]
  5. Edgerton V. R., Gerchman L., Carrow R. Histochemical changes in rat skeletal muscle after exercise. Exp Neurol. 1969 May;24(1):110–123. doi: 10.1016/0014-4886(69)90009-0. [DOI] [PubMed] [Google Scholar]
  6. Edström L., Kugelberg E. Histochemical composition, distribution of fibres and fatiguability of single motor units. Anterior tibial muscle of the rat. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):424–433. doi: 10.1136/jnnp.31.5.424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Edström L., Kugelberg E. Histochemical mapping of motor units in experimentally re-innervated skeletal muscle. Experientia. 1969 Oct 15;25(10):1044–1045. doi: 10.1007/BF01901417. [DOI] [PubMed] [Google Scholar]
  8. Edström L., Torlegard K. Area estimation of transversely sectioned muscle fibres. Z Wiss Mikrosk. 1969 Jun;69(3):166–178. [PubMed] [Google Scholar]
  9. Engel W. K., Brooke M. H., Nelson P. G. Histochemical studies of denervated or tenotomized cat muscle: illustrating difficulties in relating experimental animal conditions to human neuromuscular diseases. Ann N Y Acad Sci. 1966 Sep 9;138(1):160–185. doi: 10.1111/j.1749-6632.1966.tb41164.x. [DOI] [PubMed] [Google Scholar]
  10. Gutmann E., Young J. Z. The re-innervation of muscle after various periods of atrophy. J Anat. 1944 Jan;78(Pt 1-2):15–43. [PMC free article] [PubMed] [Google Scholar]
  11. HOFFMAN H. Local re-innervation in partially denervated muscle; a histophysiological study. Aust J Exp Biol Med Sci. 1950 Jul;28(4):383–397. doi: 10.1038/icb.1950.39. [DOI] [PubMed] [Google Scholar]
  12. Karpati G., Engel W. K. "Type grouping" in skeletal muscles after experimental reinnervation. Neurology. 1968 May;18(5):447–455. doi: 10.1212/wnl.18.5.447. [DOI] [PubMed] [Google Scholar]
  13. Karpati G., Engel W. K. Histochemical investigation of fiber type ratios with the myofibrillar ATP-ase reaction in normal and denervated skeletal muscles of guinea pig. Am J Anat. 1968 Jan;122(1):145–155. doi: 10.1002/aja.1001220109. [DOI] [PubMed] [Google Scholar]
  14. Kugelberg E., Edström L. Differential histochemical effects of muscle contractions on phosphorylase and glycogen in various types of fibres: relation to fatigue. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):415–423. doi: 10.1136/jnnp.31.5.415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. PADYKULA H. A., HERMAN E. The specificity of the histochemical method for adenosine triphosphatase. J Histochem Cytochem. 1955 May;3(3):170–195. doi: 10.1177/3.3.170. [DOI] [PubMed] [Google Scholar]
  16. Robbins N., Karpati G., Engel W. K. Histochemical and contractile properties in the cross-innervated guinea pig soleus muscle. Arch Neurol. 1969 Mar;20(3):318–329. doi: 10.1001/archneur.1969.00480090106015. [DOI] [PubMed] [Google Scholar]
  17. Romanul F. C., Van der Meulen J. P. Reversal of the enzyme profiles of muscle fibres in fast and slow muscles by cross-innervation. Nature. 1966 Dec 17;212(5068):1369–1370. doi: 10.1038/2121369a0. [DOI] [PubMed] [Google Scholar]
  18. Romanul F. C., Van der Meulen J. P. Slow and fast muscles after cross innervation. Enzymatic and physiological changes. Arch Neurol. 1967 Oct;17(4):387–402. doi: 10.1001/archneur.1967.00470280053006. [DOI] [PubMed] [Google Scholar]
  19. STEIN J. M., PADYKULA H. A. Histochemical classification of individual skeletal muscle fibers of the rat. Am J Anat. 1962 Mar;110:103–123. doi: 10.1002/aja.1001100203. [DOI] [PubMed] [Google Scholar]
  20. VAN HARREVELD A. Re-innervation of paretic muscle by collateral branching of the residual motor innervation. J Comp Neurol. 1952 Oct;97(2):385–407. doi: 10.1002/cne.900970206. [DOI] [PubMed] [Google Scholar]
  21. WOHLFART G. Collateral regeneration in partially denervated muscles. Neurology. 1958 Mar;8(3):175–180. doi: 10.1212/wnl.8.3.175. [DOI] [PubMed] [Google Scholar]
  22. YAHR M. D., HERZ E., MOLDAVER J., GRUNDFEST H. Electromyographic patterns in reinnervated muscle. Arch Neurol Psychiatry. 1950 May;63(5):728–738. doi: 10.1001/archneurpsyc.1950.02310230050004. [DOI] [PubMed] [Google Scholar]
  23. Yellin H. Neural regulation of enzymes in muscle fibers of red and white muscle. Exp Neurol. 1967 Sep;19(1):92–103. doi: 10.1016/0014-4886(67)90009-x. [DOI] [PubMed] [Google Scholar]

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