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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1971 Aug;34(4):461–468. doi: 10.1136/jnnp.34.4.461

An electrophysiological study of Duchenne dystrophy

A J McComas 1,1, R E P Sica 1,2, S Currie 1
PMCID: PMC493834  PMID: 4938134

Abstract

An electrophysiological study has been made of extensor digitorum brevis muscles in 19 boys with Duchenne dystrophy. The isometric twitches of the dystrophic muscles developed less tension and were usually slower than those in controls. Impulse conduction velocity appeared to be reduced in distal regions of nerve axons but was normal proximally. The most interesting finding was a reduction in the number of functioning units in all but one of the patients. The sizes of the surviving units suggested that the results could be explained more easily in terms of a neurogenic process than a primary myopathic one.

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Selected References

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  1. BOTELHO S. Y., BECKETT S. B., BENDLER E. Mechanical and electrical responses of intact thenar muscles to indirect stimuli: study of patients with pseudohypertrophic muscular dystrophy. Neurology. 1960 Jun;10:601–612. doi: 10.1212/wnl.10.6.601. [DOI] [PubMed] [Google Scholar]
  2. Caspary E. A., Currie S., Field E. J. Sensitized lymphocytes in muscular dystrophy: evidence for a neural factor in pathogenesis. J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):353–356. doi: 10.1136/jnnp.34.3.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Desmedt J. E., Emeryk B. Disorder of muscle contraction processes in sex-linked (Duchenne) muscular dystrophy, with correlative electromyographic study of myopathic involvement in small hand muscles. Am J Med. 1968 Dec;45(6):853–872. doi: 10.1016/0002-9343(68)90184-8. [DOI] [PubMed] [Google Scholar]
  4. Jayam A. V., Raju T. N., Pandya S. S., Desai A. D. Motor nerve conduction in Duchenne type of muscular dystrophy. Neurol India. 1970 Mar;18(1):8–12. [PubMed] [Google Scholar]
  5. Jedrzejowska-Kulakowska, Hausmanowa-Petrusewicz I., Gawlik Z., Rafalowska J., Slucka C. Zweryfikowany sekcyjnie przypadek postepujacej dystrofii mieśniowej typu Duchenne'a. Neuropatol Pol. 1968 Jan-Mar;6(1):71–85. [PubMed] [Google Scholar]
  6. Mc Comas A. J., Sica R. E., Currie S. Muscular dystrophy: evidence for a neural factor. Nature. 1970 Jun 27;226(5252):1263–1264. doi: 10.1038/2261263a0. [DOI] [PubMed] [Google Scholar]
  7. McComas A. J., Campbell M. J., Sica R. E. Electrophysiological study of dystrophia myotonica. J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):132–139. [PMC free article] [PubMed] [Google Scholar]
  8. McComas A. J., Fawcett P. R., Campbell M. J., Sica R. E. Electrophysiological estimation of the number of motor units within a human muscle. J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):121–131. doi: 10.1136/jnnp.34.2.121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McComas A. J., Thomas H. C. A study of the muscle twitch in the Duchenne type muscular dystrophy. J Neurol Sci. 1968 Sep-Oct;7(2):309–312. doi: 10.1016/0022-510x(68)90151-2. [DOI] [PubMed] [Google Scholar]
  10. NORRIS F. H., Jr, CHATFIELD P. O. Some electrophysiological aspects of muscular dystrophy. Electroencephalogr Clin Neurophysiol. 1955 Aug;7(3):391–397. doi: 10.1016/0013-4694(55)90011-0. [DOI] [PubMed] [Google Scholar]
  11. Nakao K., Kito S., Muro T., Tomonaga M., Mozai T. Nervous system involvement in progressive muscular dystrophy. Proc Aust Assoc Neurol. 1968;5(3):557–564. [PubMed] [Google Scholar]
  12. Sica R. E., McComas A. J. Fast and slow twitch units in a human muscle. J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):113–120. doi: 10.1136/jnnp.34.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]

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