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. 1981 Aug;34(8):819–835. doi: 10.1136/jcp.34.8.819

Examination of products of conception from previable human pregnancies.

D I Rushton
PMCID: PMC493949  PMID: 7024313

Abstract

The incidence, aetiology, and mechanisms of spontaneous abortion are outlined. A simplified classification of products of conception specifically orientated for routine histopathological laboratories rather than research centres is presented. Its introduction should not in itself greatly increase the work load of a service laboratory already examining such material. Specific practical problems are discussed and these are related to the clinical situation. The importance is emphasised of proper examination of tissues from pregnancies aborting after diagnostic amniocentesis, as well as those from therapeutic terminations performed for fetal abnormality or disease. Special techniques are suggested for processing suspected procured abortions. Finally the value is stressed of routine examination of spontaneously aborted material in the current and future management of the patient, in the furtherance of our knowledge of fetal diseases and of some of the major contributory factors to perinatal morbidity and mortality.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abaci F., Aterman K. Changes of the placenta and embryo in early spontaneous abortion. Am J Obstet Gynecol. 1968 Sep 15;102(2):252–263. doi: 10.1016/0002-9378(68)90328-1. [DOI] [PubMed] [Google Scholar]
  2. Berry C. L. The examination of embryonic and fetal material in diagnostic histopathology laboratories. J Clin Pathol. 1980 Apr;33(4):317–326. doi: 10.1136/jcp.33.4.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buchanan R., Sworn M. J., Noble A. D. Abortion associated with intrauterine infection by candida albicans. Case report. Br J Obstet Gynaecol. 1979 Sep;86(9):741–744. doi: 10.1111/j.1471-0528.1979.tb11278.x. [DOI] [PubMed] [Google Scholar]
  4. Butler L. J., Snodgrass G. J., Sinclair L., France N. E., Russell A. E (16-18) trisomy syndrome: analysis of 13 cases. Arch Dis Child. 1965 Dec;40(214):600–611. doi: 10.1136/adc.40.214.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dudgeon J. A. Viral infections. J Clin Pathol Suppl (R Coll Pathol) 1976;10:99–106. [PMC free article] [PubMed] [Google Scholar]
  6. Duff G. B., Evans J. J., Legge M. A study of investigations used to predict outcome of pregnancy after threatened abortion. Br J Obstet Gynaecol. 1980 Mar;87(3):194–198. doi: 10.1111/j.1471-0528.1980.tb04517.x. [DOI] [PubMed] [Google Scholar]
  7. Elston C. W., Bagshawe K. D. The diagnosis of trophoblastic tumours from uterine curettings. J Clin Pathol. 1972 Feb;25(2):111–118. [PMC free article] [PubMed] [Google Scholar]
  8. Fox M., Saunders N. R. Significance of loin pain in women. A study of 100 consecutive cases referred to a urological clinic. Lancet. 1978 Jan 21;1(8056):115–116. doi: 10.1016/s0140-6736(78)90416-6. [DOI] [PubMed] [Google Scholar]
  9. Friedman S., Gans B., Eckerling B., Goldman J., Kaufman H., Rumnny M. Placental hormone activity after removal of the fetus in a case of advanced abdominal pregnancy. J Obstet Gynaecol Br Commonw. 1969 Jun;76(6):554–558. doi: 10.1111/j.1471-0528.1969.tb05881.x. [DOI] [PubMed] [Google Scholar]
  10. Fujikura T., Froehlich L. A., Driscoll S. G. A simplified anatomic classification of abortions. Am J Obstet Gynecol. 1966 Aug 1;95(7):902–905. doi: 10.1016/0002-9378(66)90537-0. [DOI] [PubMed] [Google Scholar]
  11. Gosden C. M., Wright M. O., Paterson W. G., Grant K. A. Clinical details, cytogenic studies,and cellular physiology of a 69, XXX fetus, with comments on the biological effect of triploidy in man. J Med Genet. 1976 Oct;13(5):371–380. doi: 10.1136/jmg.13.5.371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Honoré L. H., Dill F. J., Poland B. J. Placental morphology in spontaneous human abortuses with normal and abnormal karyotypes. Teratology. 1976 Oct;14(2):151–166. doi: 10.1002/tera.1420140206. [DOI] [PubMed] [Google Scholar]
  13. Kajii T., Ohama K. Androgenetic origin of hydatidiform mole. Nature. 1977 Aug 18;268(5621):633–634. doi: 10.1038/268633a0. [DOI] [PubMed] [Google Scholar]
  14. Mikamo K. Anatomic and chromosomal anomalies in spontaneous abortion. Possible correlation with overripeness of oocytes. Am J Obstet Gynecol. 1970 Jan 15;106(2):243–254. doi: 10.1016/0002-9378(70)90269-3. [DOI] [PubMed] [Google Scholar]
  15. Miller J. F., Williamson E., Glue J., Gordon Y. B., Grudzinskas J. G., Sykes A. Fetal loss after implantation. A prospective study. Lancet. 1980 Sep 13;2(8194):554–556. doi: 10.1016/s0140-6736(80)91991-1. [DOI] [PubMed] [Google Scholar]
  16. NILSSON L. Hydatidiform degeneration in aborted ova; a histopathological and clinical study. Acta Obstet Gynecol Scand Suppl. 1957;36(Suppl 7):1–80. doi: 10.3109/00016345709155052. [DOI] [PubMed] [Google Scholar]
  17. Nishimura H., Takano K., Tanimura T., Yasuda M. Normal and abnormal development of human embryos: first report of the analysis of 1,213 intact embryos. Teratology. 1968 Aug;1(3):281–290. doi: 10.1002/tera.1420010306. [DOI] [PubMed] [Google Scholar]
  18. Park W. W. Possible functions of nonvillous trophoblast. Eur J Obstet Gynecol Reprod Biol. 1975;5(1-2):35–46. doi: 10.1016/0028-2243(75)90129-x. [DOI] [PubMed] [Google Scholar]
  19. Poland B. J., Miller J. R., Jones D. C., Trimble B. K. Reproductive counseling in patients who have had a spontaneous abortion. Am J Obstet Gynecol. 1977 Apr 1;127(7):685–691. doi: 10.1016/0002-9378(77)90240-x. [DOI] [PubMed] [Google Scholar]
  20. RAPPAPORT F., RABINOVITZ M., TOAFF R., KROCHIK N. Genital listeriosis as a cause of repeated abortion. Lancet. 1960 Jun 11;1(7137):1273–1275. doi: 10.1016/s0140-6736(60)92253-4. [DOI] [PubMed] [Google Scholar]
  21. Robertson W. B. Uteroplacental vasculature. J Clin Pathol Suppl (R Coll Pathol) 1976;10:9–17. doi: 10.1136/jcp.s3-10.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Rushton D. I., Faed M. J., Bain A. D. The fetal manifestations of the 45XO karyotype. J Obstet Gynaecol Br Commonw. 1969 Mar;76(3):266–272. doi: 10.1111/j.1471-0528.1969.tb05832.x. [DOI] [PubMed] [Google Scholar]
  23. Sheppard B. L., Bonnar J. The ultrastructure of the arterial supply of the human placenta in pregnancy complicated by fetal growth retardation. Br J Obstet Gynaecol. 1976 Dec;83(12):948–959. doi: 10.1111/j.1471-0528.1976.tb00781.x. [DOI] [PubMed] [Google Scholar]
  24. Vassilakos P., Riotton G., Kajii T. Hydatidiform mole: two entities. A morphologic and cytogenetic study with some clinical consideration. Am J Obstet Gynecol. 1977 Jan 15;127(2):167–170. doi: 10.1016/s0002-9378(16)33244-6. [DOI] [PubMed] [Google Scholar]
  25. WEINMAN D. Toxoplasma and abortion: a field for further investigation. Fertil Steril. 1960 Sep-Oct;11:525–530. doi: 10.1016/s0015-0282(16)33913-9. [DOI] [PubMed] [Google Scholar]
  26. Wigglesworth J. S. Vascular organization of the human placenta. Nature. 1967 Dec 16;216(5120):1120–1121. doi: 10.1038/2161120a0. [DOI] [PubMed] [Google Scholar]

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