Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1981 Oct;34(10):1138–1146. doi: 10.1136/jcp.34.10.1138

Pneumocystis carinii pneumonia: a light microscopical and ultrastructural study.

P S Hasleton, A Curry, E M Rankin
PMCID: PMC494380  PMID: 6975781

Abstract

A case of Pneumocystis carinii pneumonia developing a patient with treated diffuse lymphocytic lymphoma is described. The electron microscopic features and life cycle of the organism are illustrated. The patient died twenty-four hours after the biopsy had been taken. Septrin appeared to have affected the trophozoite stage. Pneumocystis carinii appears to induce interstitial pulmonary oedema and fibrosis. A discussion of the role of electron microscopy in early diagnosis of the disease is presented.

Full text

PDF
1143

Images in this article

1139Image
on p.1139
1139Image
on p.1139
1140Image
on p.1140
1141Image
on p.1141
1141Image
on p.1141
1142Image
on p.1142
1142Image
on p.1142
1143Image
on p.1143
1143Image
on p.1143
1144Image
on p.1144
1145Image
on p.1145

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burke B. A., Good R. A. Pneumocystis carinii infection. Medicine (Baltimore) 1973 Jan;52(1):23–51. doi: 10.1097/00005792-197301000-00002. [DOI] [PubMed] [Google Scholar]
  2. DeVita V. T., Jr, Goodell B., Hubbard S., Geelhoed G. W., Young R. C. Pneumocystis pneumonia in patients with cancer: clinical setting. Natl Cancer Inst Monogr. 1976 Oct;43:41–47. [PubMed] [Google Scholar]
  3. Dutz W., Post C., Vessal K., Kohout E. Endemic infantile pneumocystis carinii infection: the Shiraz study. Natl Cancer Inst Monogr. 1976 Oct;43:31–40. [PubMed] [Google Scholar]
  4. HUNEYCUTT H. C., ANDERSON W. R., HENDRY W. S. PNEUMOCYSTIS CARINII PNEUMONIA. CASE STUDIES WITH ELECTRON MICROSCOPY. Am J Clin Pathol. 1964 Apr;41:411–418. doi: 10.1093/ajcp/41.4.411. [DOI] [PubMed] [Google Scholar]
  5. HUNEYCUTT H. C., ANDERSON W. R., HENDRY W. S. PNEUMOCYSTIS CARINII PNEUMONIA. CASE STUDIES WITH ELECTRON MICROSCOPY. Am J Clin Pathol. 1964 Apr;41:411–418. doi: 10.1093/ajcp/41.4.411. [DOI] [PubMed] [Google Scholar]
  6. Harris M. Differential diagnosis of spindle cell tumours by electron microscopy--personal experience and a review. Histopathology. 1981 Jan;5(1):81–105. doi: 10.1111/j.1365-2559.1981.tb01769.x. [DOI] [PubMed] [Google Scholar]
  7. Heath D., Smith P., Hasleton P. S. Effects of chlorphentermine on the rat lung. Thorax. 1973 Sep;28(5):551–558. doi: 10.1136/thx.28.5.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hughes W. T. Pneumocystis carinii pneumonia. N Engl J Med. 1977 Dec 22;297(25):1381–1383. doi: 10.1056/NEJM197712222972505. [DOI] [PubMed] [Google Scholar]
  9. Littler W. A., Kay J. M., Hasleton P. S., Heath D. Busulphan lung. Thorax. 1969 Nov;24(6):639–655. doi: 10.1136/thx.24.6.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Price R. A., Hughes W. T. Histopathology of Pneumocystis carinii infestation and infection in malignant disease in childhood. Hum Pathol. 1974 Nov;5(6):737–752. doi: 10.1016/s0046-8177(74)80043-2. [DOI] [PubMed] [Google Scholar]
  11. Reinhardt D. J., Kaplan W., Chandler F. W. Morphologic resemblance of zygomycete spores to Pneumocystis carinii cysts in tissue. Am Rev Respir Dis. 1977 Jan;115(1):170–172. doi: 10.1164/arrd.1977.115.1.170. [DOI] [PubMed] [Google Scholar]
  12. Rowden G., Lewis M. G. Experience with a three-hour electron microscopy biopsy service. J Clin Pathol. 1974 Jun;27(6):505–510. doi: 10.1136/jcp.27.6.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Sevitt S. Diffuse and focal oxygen pneumonitis. A preliminary report on the threshold of pulmonary oxygen toxicity in man. J Clin Pathol. 1974 Jan;27(1):21–30. doi: 10.1136/jcp.27.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sueishi K., Hisano S., Sumiyoshi A., Tanaka K. Scanning and transmission electron microscopic study of human pulmonary pneumocystosis. Chest. 1977 Aug;72(2):213–216. doi: 10.1378/chest.72.2.213. [DOI] [PubMed] [Google Scholar]
  15. Tamura T., Ueda K., Furuta T., Goto Y., Fujiwara K. Electron microscopy of spontaneous pneumocystosis in a nude mouse. Jpn J Exp Med. 1978 Aug;48(4):363–368. [PubMed] [Google Scholar]
  16. Vavra J., Kucera K. Pneumocystis carinii delanoë, its ultrastructure and ultrastructural affinities. J Protozool. 1970 Aug;17(3):463–483. doi: 10.1111/j.1550-7408.1970.tb04715.x. [DOI] [PubMed] [Google Scholar]
  17. Walzer P. D., Perl D. P., Krogstad D. J., Rawson P. G., Schultz M. G. Pneumocystis carinii pneumonia in the United States. Epidemiologic, diagnostic, and clinical features. Ann Intern Med. 1974 Jan;80(1):83–93. doi: 10.7326/0003-4819-80-1-83. [DOI] [PubMed] [Google Scholar]
  18. Young R. C., DeVita V. T., Jr Treatment of Pneumocystis carinii pneumonia: current status of the regimens of pentamidine isethionate and pyrimethamine-sulfadiazine. Natl Cancer Inst Monogr. 1976 Oct;43:193–200. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES