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. 1981 Oct;34(10):1147–1154. doi: 10.1136/jcp.34.10.1147

Effect of oxygen on the lungs after blast injury and burns.

P S Hasleton, P Penna, J Torry
PMCID: PMC494381  PMID: 7309895

Abstract

In March 1979 there was an explosion in a coalmine in Lancashire. As a result three men were found dead down the mine and a further seven men, all with extensive burns, died between the third and thirteenth day after the explosion. The lungs were studied in all the cases. Pulmonary infection was the commonest cause of death. Despite high levels of oxygen being given to these seven men, only one case showed a focal intra-alveolar fibrosis. In this case the inspired oxygen requirement came down before death. The toxicity of oxygen in the short term management of patients with severe trauma is questioned.

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Selected References

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  1. Aabo K., Hansen K. B. Megakaryocytes in pulmonary blood vessels. I. Incidence at autopsy, clinicopathological relations especially to disseminated intravascular coagulation. Acta Pathol Microbiol Scand A. 1978 Jul;86(4):285–291. [PubMed] [Google Scholar]
  2. Barber R. E., Hamilton W. K. Oxygen toxicity in man. A A/Barber RE, Lee J, Hamilton WK: Oxygen toxicity in man. A prospective study in patients with irreversible brain damage. N Engl J Med. 1970 Dec 31;283(27):1478–1484. doi: 10.1056/NEJM197012312832702. [DOI] [PubMed] [Google Scholar]
  3. Blaisdell F. W., Stallone R. J. The mechanism of pulmonary damage following traumatic shock. Surg Gynecol Obstet. 1970 Jan;130(1):15–22. [PubMed] [Google Scholar]
  4. Bredenberg C. E., James P. M., Collins J., Anderson R. W., Martin A. M., Jr, Hardaway R. M., 3rd Respiratory failure in shock. Ann Surg. 1969 Mar;169(3):392–403. doi: 10.1097/00000658-196903000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown L. J., Stalker A. L., Hall J. J. Experimental defibrination. II. Histological studies by light and electron microscopy. Microvasc Res. 1969 Apr;1(3):295–307. doi: 10.1016/0026-2862(69)90032-6. [DOI] [PubMed] [Google Scholar]
  6. Corrin B. Lung pathology in septic shock. J Clin Pathol. 1980 Sep;33(9):891–894. doi: 10.1136/jcp.33.9.891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Deneke S. M., Fanburg B. L. Normobaric oxygen toxicity of the lung. N Engl J Med. 1980 Jul 10;303(2):76–86. doi: 10.1056/NEJM198007103030204. [DOI] [PubMed] [Google Scholar]
  8. Johnson D. W., Kvale P. A., Afable V. L., Stewart S. D., Halverson C. W., Holmes K. K. Single-dose antibiotic treatment of asymptomatic gonorrhea in hospitalized women. N Engl J Med. 1970 Jul 2;283(1):1–6. doi: 10.1056/NEJM197007022830101. [DOI] [PubMed] [Google Scholar]
  9. Kistler G. S., Caldwell P. R., Weibel E. R. Development of fine structural damage to alveolar and capillary lining cells in oxygen-poisoned rat lungs. J Cell Biol. 1967 Mar;32(3):605–628. doi: 10.1083/jcb.32.3.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Martin A. M., Jr, Soloway H. B., Simmons R. L. Pathologic anatomy of the lungs following shock and trauma. J Trauma. 1968 Sep;8(5):687–699. doi: 10.1097/00005373-196809000-00007. [DOI] [PubMed] [Google Scholar]
  11. McCaughey W., Coppel D. L., Dundee J. W. Blast injuries to the lungs. A report of two cases. Anaesthesia. 1973 Jan;28(1):2–9. doi: 10.1111/j.1365-2044.1973.tb00277.x. [DOI] [PubMed] [Google Scholar]
  12. PRATT P. C. Pulmonary capillary proliferation induced by oxygen inhalation. Am J Pathol. 1958 Nov-Dec;34(6):1033–1049. [PMC free article] [PubMed] [Google Scholar]
  13. Sevitt S. Diffuse and focal oxygen pneumonitis. A preliminary report on the threshold of pulmonary oxygen toxicity in man. J Clin Pathol. 1974 Jan;27(1):21–30. doi: 10.1136/jcp.27.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Van De Water J. M., Kagey K. S., Miller I. T., Parker D. A., O'Connor N. E., Sheh J. M., MacArthur J. D., Zollinger R. M., Jr, Moore F. D. Response of the lung to six to 12 hours of 100 per cent oxygen inhalation in normal man. N Engl J Med. 1970 Sep 17;283(12):621–626. doi: 10.1056/NEJM197009172831203. [DOI] [PubMed] [Google Scholar]
  15. Veith F. J., Sinha S. B., Graves J. S., Boley S. J., Dougherty J. C. Ischemic tolerance of the lung. The effect of ventilation and inflation. J Thorac Cardiovasc Surg. 1971 May;61(5):804–810. [PubMed] [Google Scholar]
  16. Wolfe W. G., DeVries W. C. Oxygen toxicity. Annu Rev Med. 1975;26:203–217. doi: 10.1146/annurev.me.26.020175.001223. [DOI] [PubMed] [Google Scholar]

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