Abstract
A consecutive series is presented of 100 cases of malignant lymphoma in which a correlation could be made between the histological findings and the cytology of pleural or peritoneal fluid or both. Using the Kiel classification, 80 cases could be given a histological label, while 20 remain unclassified. In those cases in which lymphoma cells were identifiable in the serous fluid, their morphology was studied and was found in general to correlate well with the cell-type expected from the histology. It is not claimed that the type of lymphoma can be reliably diagnosed from the cytology of pleural or peritoneal fluid, but an opinion can be provided as to the grade (high or low), and in some cases it is also possible to give an indication of the cell-type involved.
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- Billingham M. E., Rawlinson D. G., Berry P. F., Kempson R. L. The cytodiagnosis of malignant lymphomas and Hodgkin's disease in cerebrospinal, pleural and ascitic fluids. Acta Cytol. 1975 Nov-Dec;19(6):547–556. [PubMed] [Google Scholar]
- Catovsky D., Galetto J., Okos A., Miliani E., Galton D. A. Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia. J Clin Pathol. 1974 Oct;27(10):767–771. doi: 10.1136/jcp.27.10.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAWE C. J., WOOLNER L. B., PARKHILL E. M., McDONALD J. R. Cytologic studies of sputum, secretions and serous fluids in malignant lymphoma. Am J Clin Pathol. 1955 May;25(5):480–488. doi: 10.1093/ajcp/25.5.480. [DOI] [PubMed] [Google Scholar]
- Dick F., Bloomfield C. D., Brunning R. D. Incidence cytology, and histopathology of non-Hodgkin's lymphomas in the bone marrow. Cancer. 1974 May;33(5):1382–1398. doi: 10.1002/1097-0142(197405)33:5<1382::aid-cncr2820330525>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- Feinberg M. R., Bhaskar A. G., Bourne P. Differential diagnosis of malignant lymphomas by imprint cytology. Acta Cytol. 1980 Jan-Feb;24(1):16–25. [PubMed] [Google Scholar]
- HUMBLE J. G., JAYNE W. H., PULVERTAFT R. J. Biological interaction between lymphocytes and other cells. Br J Haematol. 1956 Jul;2(3):283–294. doi: 10.1111/j.1365-2141.1956.tb06700.x. [DOI] [PubMed] [Google Scholar]
- Histopathological definition of Burkitt's tumour. Bull World Health Organ. 1969 Apr;40(4):601–607. [PMC free article] [PubMed] [Google Scholar]
- Hossfeld D. K., Schmidt C. G. Chromosome findings in effusions from patients with Hodgkin's disease. Int J Cancer. 1978 Feb 15;21(2):147–156. doi: 10.1002/ijc.2910210204. [DOI] [PubMed] [Google Scholar]
- IOACHIM H., FURTH J. INTRARETICULAR CELL MULTIPLICATION OF LEUKEMIC LYMPHOBLASTS IN THYMIC TISSUE CULTURES. J Natl Cancer Inst. 1964 Feb;32:339–359. [PubMed] [Google Scholar]
- Johnson W. D. The cytological diagnosis of cancer in serous effusions. Acta Cytol. 1966 May-Jun;10(3):161–172. [PubMed] [Google Scholar]
- LENNERT K. Uber die Erkennung von Keimzentrumszellen im Lymphknotenausstrich. Klin Wochenschr. 1957 Nov 15;35(22):1130–1132. doi: 10.1007/BF01489419. [DOI] [PubMed] [Google Scholar]
- LUSE S. A., REAGAN J. W. A histocytologic and electron microscopic study of effusions associated with malignant disease. Ann N Y Acad Sci. 1956 Mar 30;63(6):1331–1347. doi: 10.1111/j.1749-6632.1956.tb32141.x. [DOI] [PubMed] [Google Scholar]
- LUSE S. A., REAGAN J. W. A histocytological study of effusions. II. Effusions associated with malignant tumors. Cancer. 1954 Nov;7(6):1167–1181. doi: 10.1002/1097-0142(195411)7:6<1167::aid-cncr2820070607>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
- Li C. Y., Yam L. T., Lam K. W. Acid phosphatase isoenzyme in human leukocytes in normal and pathologic conditions. J Histochem Cytochem. 1970 Jul;18(7):473–481. doi: 10.1177/18.7.473. [DOI] [PubMed] [Google Scholar]
- Lipsky P. E., Rosenthal A. S. Macrophage-lymphocyte interaction. I. Characteristics of the antigen-independent-binding of guinea pig thymocytes and lymphocytes to syngeneic macrophages. J Exp Med. 1973 Oct 1;138(4):900–924. doi: 10.1084/jem.138.4.900. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOESCHLIN S. Phasenkontrastuntersuchungen in der Hämatologie. Acta Haematol. 1949 Dec;2(6):399–426. doi: 10.1159/000203485. [DOI] [PubMed] [Google Scholar]
- McKenna R. W., Bloomfield C. D., Brunning R. D. Nodular lymphoma: bone marrow and blood manifestations. Cancer. 1975 Aug;36(2):428–440. doi: 10.1002/1097-0142(197508)36:2<428::aid-cncr2820360218>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- McKenna R. W., Brynes R. K., Nesbit M. E., Bloomfield C. D., Kersey J. H., Spanjers E., Brunning R. D. Cycochemical profiles in acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol. 1979 Fall;1(3):263–275. doi: 10.1097/00043426-197923000-00011. [DOI] [PubMed] [Google Scholar]
- Murad T. M. Electron microscopic studies of cells in pleural and peritoneal effusions. Acta Cytol. 1973 Sep-Oct;17(5):401–409. [PubMed] [Google Scholar]
- Pinkel D., Johnson W., Aur R. J. Non-Hodgkin's lymphoma in children. Br J Cancer Suppl. 1975 Mar;2:298–323. [PMC free article] [PubMed] [Google Scholar]
- ROSENTHAL N., DRESKIN O. H., VURAL I. L., ZAK F. G. The significance of hematogones in blood, bone marrow and lymph node aspiration in giant follicular lymphoblastoma. Acta Haematol. 1952 Dec;8(6):368–377. doi: 10.1159/000204186. [DOI] [PubMed] [Google Scholar]
- Reynoso G., Chu T. M., Guinan P., Murphy G. P. Carcinoembryonic antigen in patients with tumors of the urogenital tract. Cancer. 1972 Jul;30(1):1–4. doi: 10.1002/1097-0142(197207)30:1<1::aid-cncr2820300102>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
- Rilke F., Pilotti S., Carbone A., Lombardi L. Morphology of lymphatic cells and of their derived tumours. J Clin Pathol. 1978 Nov;31(11):1009–1056. doi: 10.1136/jcp.31.11.1009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woyke S., Domagala W. Ocena cytologiczna płynów z jam ciała. 3. Komórki chłoniaków złośliwych (lymphoma malignum) Nowotwory. 1971 Jan-Mar;21(1):31–36. [PubMed] [Google Scholar]
















