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. 1974 May;37(5):502–513. doi: 10.1136/jnnp.37.5.502

Nodal gap substance in diabetic nerve

K N Seneviratne 1, A Weerasuriya 1
PMCID: PMC494694  PMID: 4276085

Abstract

Anoxia and KC1 have been used to inactivate peripheral nerves by depolarization conduction block. Investigation of the inactivation patterns in isolated sciatic nerves of healthy and alloxan-diabetic rats suggests that the paranodal gap substance of healthy nerve behaves as an effective periaxonal diffusion barrier. In diabetic nerve the permeability of this barrier is significantly increased. A marked reduction in the K' binding capacity of the nodal gap substance has been demonstrated in myelinated nerves of human diabetics and alloxan diabetic rats.

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Selected References

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