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. 1992 Apr;45(4):319–323. doi: 10.1136/jcp.45.4.319

Helicobacter pylori infection and chronic gastritis in gastric cancer.

P Sipponen 1, T U Kosunen 1, J Valle 1, M Riihelä 1, K Seppälä 1
PMCID: PMC495272  PMID: 1577969

Abstract

AIMS: To investigate the prevalence of Helicobacter pylori associated chronic gastritis in patients with gastric cancer. METHODS: Serum IgG antibodies for H pylori were determined in 54 consecutive patients with gastric carcinoma. The prevalence of H pylori in gastric mucosa was also examined histologically (modified Giemsa) in 32 patients from whom adequate biopsy specimens of the antrum and corpus were available. Thirty five patients with gastrointestinal tumours outside the stomach and 48 with non-gastrointestinal malignancies served as controls. RESULTS: Of the 54 patients, 38 (70%) had H pylori antibodies (IgG) in their serum (three additional patients had H pylori antibodies IgA, class specific but not IgG specific). This prevalence was significantly higher (p less than 0.05) than that (49%) in the 35 controls. No differences in prevalence of H pylori antibodies were found between gastric cancer cases of intestinal (IGCA) or diffuse (DGCA) type, both these types showing H pylori antibodies (IgG) in 71% of the patients. In the subgroup of 32 subjects, five patients had normal gastric mucosa and four showed corpus limited atrophy ("pernicious anaemia type" atrophy of type A). All of these nine patients had no evidence of current or previous H pylori infection in serum (no IgG antibodies) or in tissue sections (negative Giemsa staining). The remaining 23 patients had antral or pangastritis, and all had evidence of current or previous H pylori infection. CONCLUSIONS: H pylori associated chronic gastritis was the associated disease in 75% of the patients with gastric cancer occurring equally often in both IGCA and DGCA groups. About 25% of cases seem to have a normal stomach or severe corpus limited atrophy, neither of which showed evidence of concomitant H pylori infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andreica V., Dumitrascu D., Sască N., Toganel E., Suciu A., Drăghici A., Pascu O., Sască C., Suciu M., Andreica M. Helicobacter-like organisms in gastroduodenal diseases. Gastroenterol Clin Biol. 1990;14(5):437–441. [PubMed] [Google Scholar]
  2. Christiansen J. The intestinal phase of gastric acid secretion in man. Scand J Gastroenterol. 1978;13(1):1–2. doi: 10.3109/00365527809179799. [DOI] [PubMed] [Google Scholar]
  3. Correa P., Fox J., Fontham E., Ruiz B., Lin Y. P., Zavala D., Taylor N., Mackinley D., de Lima E., Portilla H. Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risks. Cancer. 1990 Dec 15;66(12):2569–2574. doi: 10.1002/1097-0142(19901215)66:12<2569::aid-cncr2820661220>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  4. Flejou J. F., Bahame P., Smith A. C., Stockbrugger R. W., Rode J., Price A. B. Pernicious anaemia and Campylobacter like organisms; is the gastric antrum resistant to colonisation? Gut. 1989 Jan;30(1):60–64. doi: 10.1136/gut.30.1.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Forman D., Sitas F., Newell D. G., Stacey A. R., Boreham J., Peto R., Campbell T. C., Li J., Chen J. Geographic association of Helicobacter pylori antibody prevalence and gastric cancer mortality in rural China. Int J Cancer. 1990 Oct 15;46(4):608–611. doi: 10.1002/ijc.2910460410. [DOI] [PubMed] [Google Scholar]
  6. Fox J. G., Correa P., Taylor N. S., Zavala D., Fontham E., Janney F., Rodriguez E., Hunter F., Diavolitsis S. Campylobacter pylori-associated gastritis and immune response in a population at increased risk of gastric carcinoma. Am J Gastroenterol. 1989 Jul;84(7):775–781. [PubMed] [Google Scholar]
  7. Howson C. P., Hiyama T., Wynder E. L. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27. doi: 10.1093/oxfordjournals.epirev.a036288. [DOI] [PubMed] [Google Scholar]
  8. JARVI O., LAUREN P. On the role of heterotopias of the intestinal epithelium in the pathogenesis of gastric cancer. Acta Pathol Microbiol Scand. 1951;29(1):26–44. [PubMed] [Google Scholar]
  9. Jaskiewicz K., Louwrens H. D., Woodroof C. W., van Wyk M. J., Price S. K. The association of Campylobacter pylori with mucosal pathological changes in a population at risk for gastric cancer. S Afr Med J. 1989 May 6;75(9):417–419. [PubMed] [Google Scholar]
  10. Karnes W. E., Jr, Samloff I. M., Siurala M., Kekki M., Sipponen P., Kim S. W., Walsh J. H. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991 Jul;101(1):167–174. doi: 10.1016/0016-5085(91)90474-y. [DOI] [PubMed] [Google Scholar]
  11. Kato I., Tominaga S., Ito Y., Kobayashi S., Yoshii Y., Matsuura A., Kameya A., Kano T. A comparative case-control analysis of stomach cancer and atrophic gastritis. Cancer Res. 1990 Oct 15;50(20):6559–6564. [PubMed] [Google Scholar]
  12. Kekki M., Siurala M., Varis K., Sipponen P., Sistonen P., Nevanlinna H. R. Classification principles and genetics of chronic gastritis. Scand J Gastroenterol Suppl. 1987;141:1–28. [PubMed] [Google Scholar]
  13. Kosunen T. U., Hök J., Rautelin H. I., Myllylä G. Age-dependent increase of Campylobacter pylori antibodies in blood donors. Scand J Gastroenterol. 1989 Jan;24(1):110–114. doi: 10.3109/00365528909092247. [DOI] [PubMed] [Google Scholar]
  14. Kubo T. Histologic appearance of gastric carcinoma in high and low mortality countries: comparison between Kyushu, Japan and Minnesota, USA. Cancer. 1971 Sep;28(3):726–734. doi: 10.1002/1097-0142(197109)28:3<726::aid-cncr2820280331>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  15. Loffeld R. J., Willems I., Flendrig J. A., Arends J. W. Helicobacter pylori and gastric carcinoma. Histopathology. 1990 Dec;17(6):537–541. doi: 10.1111/j.1365-2559.1990.tb00793.x. [DOI] [PubMed] [Google Scholar]
  16. Mecklin J. P., Nordling S., Saario I. Carcinoma of the stomach and its heredity in young patients. Scand J Gastroenterol. 1988 Apr;23(3):307–311. doi: 10.3109/00365528809093870. [DOI] [PubMed] [Google Scholar]
  17. Price A. B. The Sydney System: histological division. J Gastroenterol Hepatol. 1991 May-Jun;6(3):209–222. doi: 10.1111/j.1440-1746.1991.tb01468.x. [DOI] [PubMed] [Google Scholar]
  18. Robey-Cafferty S. S., Ro J. Y., Cleary K. R. The prevalence of Campylobacter pylori in gastric biopsies from cancer patients. Mod Pathol. 1989 Sep;2(5):473–476. [PubMed] [Google Scholar]
  19. Sipponen P., Järvi O., Kekki M., Siurala M. Decreased incidences of intestinal and diffuse types of gastric carcinoma in Finland during a 20-year period. Scand J Gastroenterol. 1987 Sep;22(7):865–871. doi: 10.3109/00365528708991927. [DOI] [PubMed] [Google Scholar]
  20. Sipponen P., Kekki M., Haapakoski J., Ihamäki T., Siurala M. Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. Int J Cancer. 1985 Feb 15;35(2):173–177. doi: 10.1002/ijc.2910350206. [DOI] [PubMed] [Google Scholar]
  21. Sipponen P., Kekki M., Siurala M. Increased risk of gastric cancer in males affects the intestinal type of cancer and is independent of age, location of the tumour and atrophic gastritis. Br J Cancer. 1988 Mar;57(3):332–336. doi: 10.1038/bjc.1988.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sitas F., Forman D., Yarnell J. W., Burr M. L., Elwood P. C., Pedley S., Marks K. J. Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut. 1991 Jan;32(1):25–28. doi: 10.1136/gut.32.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Siurala M., Sipponen P., Kekki M. Campylobacter pylori in a sample of Finnish population: relations to morphology and functions of the gastric mucosa. Gut. 1988 Jul;29(7):909–915. doi: 10.1136/gut.29.7.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Siurala M., Sipponen P., Kekki M. Chronic gastritis: dynamic and clinical aspects. Scand J Gastroenterol Suppl. 1985;109:69–76. doi: 10.3109/00365528509103939. [DOI] [PubMed] [Google Scholar]
  25. Siurala M., Varis K., Kekki M. New aspects on epidemiology, genetics, and dynamics of chronic gastritis. Front Gastrointest Res. 1980;6:148–166. doi: 10.1159/000403329. [DOI] [PubMed] [Google Scholar]
  26. Teh M., Lee Y. S. Intestinal and diffuse carcinoma of the stomach among the ethnic and dialect groups in Singapore. Cancer. 1987 Aug 15;60(4):921–925. doi: 10.1002/1097-0142(19870815)60:4<921::aid-cncr2820600435>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]

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