Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1991 Oct;44(10):840–843. doi: 10.1136/jcp.44.10.840

Oestrogen receptors in conjunctival malignant melanoma: immunocytochemical study using formalin fixed paraffin wax sections.

D A Paridaens 1, R A Alexander 1, J L Hungerford 1, A C McCartney 1
PMCID: PMC496670  PMID: 1960218

Abstract

In a group of 15 women with conjunctival malignant melanoma six cases (40%) were shown to have oestrogen receptor positivity using a monoclonal antibody to oestrogen receptor related antigen (ER-D5, Amersham RPN.710) on formalin fixed, paraffin wax sections. Receptors were also present in the epithelium of these six cases but not in controls and cases without ER-D5 positivity in their tumours. A subset of these aggressive, intractable unilateral tumours may therefore be amenable to hormone treatment.

Full text

PDF
841

Images in this article

841Image
on p.841
841Image
on p.841
842Image
on p.842

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BYRD B. F., Jr, McGANITY W. J. The effect of pregnancy on the clinical course of malignant melanoma. South Med J. 1954 Mar;47(3):196–200. doi: 10.1097/00007611-195403000-00002. [DOI] [PubMed] [Google Scholar]
  2. Börner R., Goder G. Melanoblastom der Uvea und Schwangerschaft. Klin Monbl Augenheilkd. 1966;149(5):684–693. [PubMed] [Google Scholar]
  3. Chaudhuri P. K., Walker M. J., Briele H. A., Beattie C. W., Gupta T. K. Incidence of estrogen receptor in benign nevi and human malignant melanoma. JAMA. 1980 Aug 22;244(8):791–793. [PubMed] [Google Scholar]
  4. Chaudhuri P. K., Walker M. J., Briele H. A., Beattie C. W., Gupta T. K. Incidence of estrogen receptor in benign nevi and human malignant melanoma. JAMA. 1980 Aug 22;244(8):791–793. [PubMed] [Google Scholar]
  5. Coffer A. I., Spiller G. H., Lewis K. M., King R. J. Immunoradiometric studies with monoclonal antibody against a component related to human estrogen receptor. Cancer Res. 1985 Aug;45(8):3694–3698. [PubMed] [Google Scholar]
  6. Colvard D. S., Jankus W. R., Berg N. J., Graham M. L., 2nd, Jiang N. S., Ingle J. N., Spelsberg T. C. Microassay for nuclear binding of steroid receptors with use of intact cells from small samples of avian and human tissue. Clin Chem. 1988 Feb;34(2):363–369. [PubMed] [Google Scholar]
  7. Creagan E. T., Ingle J. N., Ahmann D. L., Green S. J. Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma. Cancer. 1982 Apr 1;49(7):1353–1354. doi: 10.1002/1097-0142(19820401)49:7<1353::aid-cncr2820490707>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  8. Creagan E. T., Ingle J. N., Woods J. E., Pritchard D. J., Jiang N. S. Estrogen receptors in patients with malignant melanoma. Cancer. 1980 Oct 15;46(8):1785–1786. doi: 10.1002/1097-0142(19801015)46:8<1785::aid-cncr2820460815>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  9. Ellerbroek W. C. Oral contraceptives and malignant melanoma. JAMA. 1968 Oct 14;206(3):649–650. doi: 10.1001/jama.1968.03150030105038. [DOI] [PubMed] [Google Scholar]
  10. Frenkel M., Klein H. Z. Malignant melanoma of the choroid in pregnancy. Am J Ophthalmol. 1966 Nov;62(5):910–913. doi: 10.1016/0002-9394(66)91917-9. [DOI] [PubMed] [Google Scholar]
  11. GEORGE P. A., FORTNER J. G., PACK G. T. Melanoma with pregnancy. A report of 115 cases. Cancer. 1960 Jul-Aug;13:854–859. doi: 10.1002/1097-0142(196007/08)13:4<854::aid-cncr2820130431>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  12. Gans L. A., Lee S. F., Lemp M. A., Pepose J. S. Estrogen and progesterone receptors and human conjunctiva. Am J Ophthalmol. 1990 Apr 15;109(4):474–477. doi: 10.1016/s0002-9394(14)74616-1. [DOI] [PubMed] [Google Scholar]
  13. Howanitz J. H. Hormone receptors and breast cancer. Hum Pathol. 1981 Dec;12(12):1057–1059. doi: 10.1016/s0046-8177(81)80327-9. [DOI] [PubMed] [Google Scholar]
  14. Karakousis C. P., Lopez R. E., Bhakoo H. S., Rosen F., Moore R., Carlson M. Estrogen and progesterone receptors and tamoxifen in malignant melanoma. Cancer Treat Rep. 1980 Jun-Jul;64(6-7):819–827. [PubMed] [Google Scholar]
  15. Lerner A. B., Nordlund J. J., Kirkwood J. M. Effects of oral contraceptives and pregnancy on melanomas. N Engl J Med. 1979 Jul 5;301(1):47–47. doi: 10.1056/nejm197907053010114. [DOI] [PubMed] [Google Scholar]
  16. Lopez R. E., Bhakoo H., Paolini N. S., Rosen F., Holyoke E. D., Goldrosen M. H. Effect of estrogen on the growth of B-16 melanoma. Surg Forum. 1978;29:153–154. [PubMed] [Google Scholar]
  17. McCarty K. S., Jr, Wortman J., Stowers S., Lubahn D. B., McCarty K. S., Sr, Seigler H. F. Sex steroid receptor analysis in human melanoma. Cancer. 1980 Sep 15;46(6):1463–1470. doi: 10.1002/1097-0142(19800915)46:6<1463::aid-cncr2820460628>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  18. PACK G. T., SCHARNAGEL I. M. The prognosis for malignant melanoma in the pregnant woman. Cancer. 1951 Mar;4(2):324–334. doi: 10.1002/1097-0142(195103)4:2<324::aid-cncr2820040218>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  19. Poulsen H. S., Ozzello L., King W. J., Greene G. L. The use of monoclonal antibodies to estrogen receptors (ER) for immunoperoxidase detection of ER in paraffin sections of human breast cancer tissue. J Histochem Cytochem. 1985 Feb;33(2):87–92. doi: 10.1177/33.2.2578501. [DOI] [PubMed] [Google Scholar]
  20. Proctor J. W., Auclair B. G., Stokowski L. Endrocrine factors and the growth and spread of B16 melanoma. J Natl Cancer Inst. 1976 Nov;57(5):1197–1198. doi: 10.1093/jnci/57.5.1197. [DOI] [PubMed] [Google Scholar]
  21. SIEGEL R., AINSLIE W. H. Malignant ocular melanoma during pregnancy. JAMA. 1963 Aug 10;185:542–543. doi: 10.1001/jama.1963.03060060140028. [DOI] [PubMed] [Google Scholar]
  22. Sadoff L., Winkley J., Tyson S. Is malignant melanoma an endocrine-dependent tumor? The possible adverse effect of estrogen. Oncology. 1973;27(3):244–257. doi: 10.1159/000224736. [DOI] [PubMed] [Google Scholar]
  23. Seddon J. M., MacLaughlin D. T., Albert D. M., Gragoudas E. S., Ference M., 3rd Uveal melanomas presenting during pregnancy and the investigation of oestrogen receptors in melanomas. Br J Ophthalmol. 1982 Nov;66(11):695–704. doi: 10.1136/bjo.66.11.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Shaw H. M., Milton G. W., Farago G., McCarthy W. H. Endocrine influences on survival from malignant melanoma. Cancer. 1978 Aug;42(2):669–677. doi: 10.1002/1097-0142(197808)42:2<669::aid-cncr2820420238>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  25. Shimada A., Kimura S., Abe K., Nagasaki K., Adachi I., Yamaguchi K., Suzuki M., Nakajima T., Miller L. S. Immunocytochemical staining of estrogen receptor in paraffin sections of human breast cancer by use of monoclonal antibody: comparison with that in frozen sections. Proc Natl Acad Sci U S A. 1985 Jul;82(14):4803–4807. doi: 10.1073/pnas.82.14.4803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Shousha S., Coady A. T., Stamp T., James K. R., Alaghband-Zadeh J. Oestrogen receptors in mucinous carcinoma of the breast: an immunohistological study using paraffin wax sections. J Clin Pathol. 1989 Sep;42(9):902–905. doi: 10.1136/jcp.42.9.902. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Stevens R. G., Lee J. A., Moolgavkar S. H. No association between oral contraceptives and malignant melanomas. N Engl J Med. 1980 Apr 24;302(17):966–966. doi: 10.1056/NEJM198004243021713. [DOI] [PubMed] [Google Scholar]
  28. WHITE L. P., LINDEN G., BRESLOW L., HARZFELD L. Studies on melanoma. The effect of pregnancy on survival in human melanoma. JAMA. 1961 Jul 29;177:235–238. doi: 10.1001/jama.1961.03040300007002. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES