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. 1982 Mar;35(3):257–284. doi: 10.1136/jcp.35.3.257

Bone biopsy in haematological disorders.

R Burkhardt, B Frisch, R Bartl
PMCID: PMC497529  PMID: 7040489

Abstract

Bone marrow biopsies are now widely used in the investigation and follow-up of many diseases. Semi-thin sections of 8216 undecalcified biopsies of patients with haematological disorders were studied. Observations were made on the cytopenias and the myelodysplastic syndromes, the acute leukaemias the myeloproliferative disorders, Hodgkin's disease and the malignant lymphomas including multiple myeloma, hairy cell leukaemia and angioimmunoblastic lymphadenopathy. Bone marrow biopsies are essential for the differential diagnosis of most cytopenias and for the early recognition of fibrosis which most frequently occurred as a consequence of megakaryocytic proliferation in the myeloproliferative disorders. Different patterns of bone marrow involvement were found in the lymphoproliferative disorders and both their type and extent constituted factors of prognostic significance. A survey of the literature is given and the conclusion is drawn that bone marrow biopsies provide indispensible information for the diagnostic evaluation and the follow-up of patients with haematological disorders.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abramson S., Miller R. G., Phillips R. A. The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med. 1977 Jun 1;145(6):1567–1579. doi: 10.1084/jem.145.6.1567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adamson J. W., Fialkow P. J. The pathogenesis of myeloproliferative syndromes. Br J Haematol. 1978 Mar;38(3):299–303. doi: 10.1111/j.1365-2141.1978.tb01048.x. [DOI] [PubMed] [Google Scholar]
  3. Aisenberg A. C. Current concepts in immunology: Cell-surface markers in lymphoproliferative disease. N Engl J Med. 1981 Feb 5;304(6):331–336. doi: 10.1056/NEJM198102053040606. [DOI] [PubMed] [Google Scholar]
  4. Ault K. A. Detection of small numbers of monoclonal B lymphocytes in the blood of patients with lymphoma. N Engl J Med. 1979 Jun 21;300(25):1401–1405. doi: 10.1056/NEJM197906213002501. [DOI] [PubMed] [Google Scholar]
  5. BLOCK M., JACOBSON L. O., BETHARD W. F. Preleukemic acute human leukemia. J Am Med Assoc. 1953 Jul 11;152(11):1018–1028. doi: 10.1001/jama.1953.03690110032010. [DOI] [PubMed] [Google Scholar]
  6. Bain B. Extensive bone marrow infarction followed by myelofibrosis in patient with Ph' positive chronic granulocytic leukaemia. J Clin Pathol. 1980 May;33(5):449–453. doi: 10.1136/jcp.33.5.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bamberg M., Donhuijsen K., Höher P. G., Holfeld H., Hossfeld D. K. Malignant progression of angioimmunoblastic lymphadenopathy. J Cancer Res Clin Oncol. 1979 Apr 12;93(3):255–263. doi: 10.1007/BF00964581. [DOI] [PubMed] [Google Scholar]
  8. Bartl R., Burkhardt R., Vondracek H., Sommerfeld W., Hagemeister E. Rationelle Beckenkamm-Biopsie Längsteilung der Proben zur Anwendung von mehreren Präparationsverfahren ohne Materialverlust. Klin Wochenschr. 1978 Jun 1;56(11):545–550. doi: 10.1007/BF01477250. [DOI] [PubMed] [Google Scholar]
  9. Bearman R. M., Pangalis G. A., Rappaport H. Acute ("malignant") myelosclerosis. Cancer. 1979 Jan;43(1):279–293. doi: 10.1002/1097-0142(197901)43:1<279::aid-cncr2820430141>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  10. Benbassat J., Penchas S., Ligumski M. Splenectomy in patients with agnogenic myeloid metaplasia: an analysis of 321 published cases. Br J Haematol. 1979 Jun;42(2):207–214. doi: 10.1111/j.1365-2141.1979.tb01125.x. [DOI] [PubMed] [Google Scholar]
  11. Berk P. D., Goldberg J. D., Silverstein M. N., Weinfeld A., Donovan P. B., Ellis J. T., Landaw S. A., Laszlo J., Najean Y., Pisciotta A. V. Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. N Engl J Med. 1981 Feb 19;304(8):441–447. doi: 10.1056/NEJM198102193040801. [DOI] [PubMed] [Google Scholar]
  12. Binet J. L., Leporrier M., Dighiero G., Charron D., D'Athis P., Vaugier G., Beral H. M., Natali J. C., Raphael M., Nizet B. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer. 1977 Aug;40(2):855–864. doi: 10.1002/1097-0142(197708)40:2<855::aid-cncr2820400239>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  13. Bird T., Proctor S. J. Malignant myelosclerosis. Myeloproliferative disorder or leukemia? Am J Clin Pathol. 1977 Jun;67(6):512–520. doi: 10.1093/ajcp/67.6.512. [DOI] [PubMed] [Google Scholar]
  14. Bloomfield C. D., Kersey J. H., Brunning R. D., Gajl-Peczalska K. J. Prognostic significance of lymphocytic surface markers and histology in adult non-Hodgkin's lymphoma. Cancer Treat Rep. 1977 Sep;61(6):963–970. [PubMed] [Google Scholar]
  15. Boggs D. R. The hematopoietic microenvironment. N Engl J Med. 1980 Jun 12;302(24):1359–1360. doi: 10.1056/NEJM198006123022409. [DOI] [PubMed] [Google Scholar]
  16. Brearley R. L., Chapman J., Cullen M. H., Horton M. A., Stansfeld A. G., Waters A. H. Haematological features of angioimmunoblastic lymphadenopathy with dysproteinaemia. J Clin Pathol. 1979 Apr;32(4):356–360. doi: 10.1136/jcp.32.4.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Brodsky I. The differential diagnosis of the polycythemic states. Ann Clin Lab Sci. 1980 Jul-Aug;10(4):311–319. [PubMed] [Google Scholar]
  18. Brynes R. K., McKenna R. W., Sundberg R. D. Bone marrow aspiration and trephine biopsy. An approach to a thorough study. Am J Clin Pathol. 1978 Nov;70(5):753–759. doi: 10.1093/ajcp/70.5.753. [DOI] [PubMed] [Google Scholar]
  19. Burkhardt R., Bartl R., Demmler K., Kettner G. Zwölf histobioptische thesen zur pathogenese der primären und sekundären osteoporose. Klin Wochenschr. 1981 Jan 2;59(1):5–18. doi: 10.1007/BF01477325. [DOI] [PubMed] [Google Scholar]
  20. Burkhardt R., Zettl K., Bartl R. Significance of non-specific changes of the bone marrow tissues from the bioptic viewpoint. Bibl Haematol. 1978;45:38–49. doi: 10.1159/000402182. [DOI] [PubMed] [Google Scholar]
  21. Campuzano G., Bedoya V., Restrepo A., Maya L. M. Utilidad de la biopsia de medula ósea en hematologia. Sangre (Barc) 1978;23(2):138–148. [PubMed] [Google Scholar]
  22. Carter A., Tatarsky I. The physiopathological significance of benign monoclonal gammopathy: a study of 64 cases. Br J Haematol. 1980 Dec;46(4):565–574. doi: 10.1111/j.1365-2141.1980.tb06013.x. [DOI] [PubMed] [Google Scholar]
  23. Castro-Malaspina H., Gay R. E., Resnick G., Kapoor N., Meyers P., Chiarieri D., McKenzie S., Broxmeyer H. E., Moore M. A. Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood. 1980 Aug;56(2):289–301. [PubMed] [Google Scholar]
  24. Cawley J. C., Burns G. F., Bevan A., Worman C. P., Smith J. L., Gray L., Barker C. R., Hayhoe F. G. Typical hairy-cell leukaemia with IgGk paraproteinaemia. Br J Haematol. 1979 Oct;43(2):215–221. doi: 10.1111/j.1365-2141.1979.tb03744.x. [DOI] [PubMed] [Google Scholar]
  25. Chabner B. A., Haskell C. M., Canellos G. P. Destructive bone lesions in chronic granulocytic leukemia. Medicine (Baltimore) 1969 Sep;48(5):401–410. doi: 10.1097/00005792-196909000-00003. [DOI] [PubMed] [Google Scholar]
  26. Chambers T. J. The cellular basis of bone resorption. Clin Orthop Relat Res. 1980 Sep;(151):283–293. [PubMed] [Google Scholar]
  27. Charron D., Robert L., Couty M. C., Binet J. L. Biochemical and histological analysis of bone marrow collagen in myelofibrosis. Br J Haematol. 1979 Feb;41(2):151–161. doi: 10.1111/j.1365-2141.1979.tb05843.x. [DOI] [PubMed] [Google Scholar]
  28. Chusid M. J., Dale D. C., West B. C., Wolff S. M. The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 1975 Jan;54(1):1–27. [PubMed] [Google Scholar]
  29. Clough V., Geary C. G., Hashmi K., Davson J., Knowlson T. Myelofibrosis in chronic granulocytic leukaemia. Br J Haematol. 1979 Aug;42(4):515–526. doi: 10.1111/j.1365-2141.1979.tb01164.x. [DOI] [PubMed] [Google Scholar]
  30. Coccia P. F., Krivit W., Cervenka J., Clawson C., Kersey J. H., Kim T. H., Nesbit M. E., Ramsay N. K., Warkentin P. I., Teitelbaum S. L. Successful bone-marrow transplantation for infantile malignant osteopetrosis. N Engl J Med. 1980 Mar 27;302(13):701–708. doi: 10.1056/NEJM198003273021301. [DOI] [PubMed] [Google Scholar]
  31. Conrad M. E., Carpenter J. T. Bone marrow necrosis. Am J Hematol. 1979;7(2):181–189. doi: 10.1002/ajh.2830070211. [DOI] [PubMed] [Google Scholar]
  32. Cowan J. D., Rubin R. N., Kies M. S., Cerezo L. Bone marrow necrosis. Cancer. 1980 Nov 15;46(10):2168–2171. doi: 10.1002/1097-0142(19801115)46:10<2168::aid-cncr2820461011>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  33. DAMESHEK W. Some speculations on the myeloproliferative syndromes. Blood. 1951 Apr;6(4):372–375. [PubMed] [Google Scholar]
  34. Dancey J. T., Brubaker L. H. Neutrophil marrow profiles in patients with rheumatoid arthritis and neutropenia. Br J Haematol. 1979 Dec;43(4):607–617. doi: 10.1111/j.1365-2141.1979.tb03793.x. [DOI] [PubMed] [Google Scholar]
  35. Dancey J. T., Deubelbeiss K. A., Harker L. A., Greenaway J. Section preparation of human marrow for light microscopy. J Clin Pathol. 1976 Aug;29(8):704–710. doi: 10.1136/jcp.29.8.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Dancey J. T., Vadnais-Metz L. H. A quantitative assessment of neutrophil marrow in seven patients with chronic granulocytic leukaemia. Br J Haematol. 1978 Jul;39(3):325–338. doi: 10.1111/j.1365-2141.1978.tb01105.x. [DOI] [PubMed] [Google Scholar]
  37. Delacrétaz F., Schmidt P. M. Intérêt et limites de l'examen combiné cytohistologique de la moelle hématopoïtique. Schweiz Med Wochenschr. 1979 Jan 6;109(1):13–18. [PubMed] [Google Scholar]
  38. Demmler K., Burkhardt R., Prechtel K. Megakaryoblastische Myelose. Klin Wochenschr. 1970 Oct 1;48(19):1168–1173. doi: 10.1007/BF01486634. [DOI] [PubMed] [Google Scholar]
  39. Demmler K., Burkhardt R. Relations between fatty tissue, cancellous bone and vascular pattern of the iliac bone in aplastic anaemia. Bibl Haematol. 1978;45:109–117. doi: 10.1159/000402191. [DOI] [PubMed] [Google Scholar]
  40. Difford J. A simplified method for the preparation of methyl methacrylate embedding medium for undecalcified bone. Med Lab Technol. 1974 Jan;31(1):79–81. [PubMed] [Google Scholar]
  41. Dodsworth H. Primary thrombocythaemia in monozygotic twins. Br Med J. 1980 Jun 21;280(6230):1506–1506. doi: 10.1136/bmj.280.6230.1506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Dosik H., Rosner F., Sawitsky A. Acquired lipidosis: Gaucher-like cells and "blue cells" in chronic granulocytic leukemia. Semin Hematol. 1972 Jul;9(3):309–316. [PubMed] [Google Scholar]
  43. Dubner H. N., Crowley J. J., Schilling R. F. Prognostic value of nucleoli and cell size in chronic lymphocytic leukemia. Am J Hematol. 1978;4(4):337–341. doi: 10.1002/ajh.2830040405. [DOI] [PubMed] [Google Scholar]
  44. Duhamel G., Muratore R., Bryon P., Horschowski N. Histological prognosis in aplastic anaemia. Bibl Haematol. 1978;45:87–95. doi: 10.1159/000402188. [DOI] [PubMed] [Google Scholar]
  45. Fitchen J. H., Cline M. J. Recent developments in understanding the pathogenesis of aplastic anemia. Am J Hematol. 1978;5(4):365–372. doi: 10.1002/ajh.2830050412. [DOI] [PubMed] [Google Scholar]
  46. Foucar K., McKenna R. W., Frizzera G., Brunning R. D. Incidence and patterns of bone marrow and blood involvement by lymphoma in relationship to the Lukes-Collins classification. Blood. 1979 Dec;54(6):1417–1422. [PubMed] [Google Scholar]
  47. Garrett J. V., Scarffe J. H., Newton R. K. Abnormal peripheral blood lymphocytes and bone marrow infiltration in non-Hodgkin's lymphoma. Br J Haematol. 1979 May;42(1):41–50. doi: 10.1111/j.1365-2141.1979.tb03696.x. [DOI] [PubMed] [Google Scholar]
  48. Georgii A., Thiele J., Vykoupil K. F. Osteomyelofibrosis/-sclerosis: a histological and cytogenetic study on core biopsies of the bone marrow. Virchows Arch A Pathol Anat Histol. 1980;389(3):269–286. doi: 10.1007/BF00430655. [DOI] [PubMed] [Google Scholar]
  49. Georgii A., Vykoupil K. F., Thiele J. Chronic megakaryocytic granulocytic myelosis-CMGM. A subtype of chronic myeloid leukemia. Virchows Arch A Pathol Anat Histol. 1980;389(3):253–268. doi: 10.1007/BF00430654. [DOI] [PubMed] [Google Scholar]
  50. Goasguen J., Mignot J., Quennehen F., Ferrand B., Le Prise P. Y., Leblay R., Guérin D., Richier J. L. Etude de la myélofibrose des maladies du sang par analyse automatique d'image. Nouv Rev Fr Hematol. 1979;21(1):17–29. [PubMed] [Google Scholar]
  51. Golde D. W., Hocking W. G., Quan S. G., Sparkes R. S., Gale R. P. Origin of human bone marrow fibroblasts. Br J Haematol. 1980 Feb;44(2):183–187. doi: 10.1111/j.1365-2141.1980.tb01200.x. [DOI] [PubMed] [Google Scholar]
  52. Gordon M. Y., King J. A., Gordon-Smith E. C. Bone marrow fibroblasts, fat cells and colony-stimulating activity. Br J Haematol. 1980 Sep;46(1):151–152. doi: 10.1111/j.1365-2141.1980.tb05948.x. [DOI] [PubMed] [Google Scholar]
  53. Gray J. L., Jacobs A., Block M. Bone marrow and peripheral blood lymphocytosis in the prognosis of chronic lymphocytic leukemia. Cancer. 1974 Apr;33(4):1169–1178. doi: 10.1002/1097-0142(197404)33:4<1169::aid-cncr2820330441>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  54. Griffiths D. A. Radioautographic studies of the lymphocytic bone marrow. Blood. 1969 Nov;34(5):696–700. [PubMed] [Google Scholar]
  55. Groopman J. E. The pathogenesis of myelofibrosis in myeloproliferative disorders. Ann Intern Med. 1980 Jun;92(6):857–858. doi: 10.7326/0003-4819-92-6-857. [DOI] [PubMed] [Google Scholar]
  56. Gutensohn N., Cole P. Childhood social environment and Hodgkin's disease. N Engl J Med. 1981 Jan 15;304(3):135–140. doi: 10.1056/NEJM198101153040302. [DOI] [PubMed] [Google Scholar]
  57. Habeshaw J. A., Catley P. F., Stansfeld A. G., Brearley R. L. Surface phenotyping, histology and the nature of non-Hodgkin lymphoma in 157 patients. Br J Cancer. 1979 Jul;40(1):11–34. doi: 10.1038/bjc.1979.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Hagler L., Pastore R. A., Bergin J. J., Wrensch M. R. Aplastic anemia following viral hepatitis: report of two fatal cases and literature review. Medicine (Baltimore) 1975 Mar;54(2):139–164. [PubMed] [Google Scholar]
  59. Hahner U., Burkhardt R. Knochenmarksdiagnostik bei Haarzell-Leukämie. Klin Wochenschr. 1977 Oct 1;55(19):933–944. doi: 10.1007/BF01479225. [DOI] [PubMed] [Google Scholar]
  60. Heidrecheid N., Charron D., d'Athis P., Raphael M., Binet J. L. Etude quantitative des adipocytes de la moelle dans l'insuffisance médullaire. Pathol Biol (Paris) 1979 Apr;27(4):215–217. [PubMed] [Google Scholar]
  61. Helleberg-Rasmussen I., Sondergaard-Petersen H. Bone-marrow biopsy with the bordier trephine. Scand J Haematol. 1975 Apr;14(2):123–128. doi: 10.1111/j.1600-0609.1975.tb00305.x. [DOI] [PubMed] [Google Scholar]
  62. Hernandez-Nieto L., Montserrat-Costa E., Muncunill J., Rozman C. Bone-marrow patterns and clinical staging in chronic lymphocytic leukaemia. Lancet. 1977 Jun 11;1(8024):1269–1269. doi: 10.1016/s0140-6736(77)92489-8. [DOI] [PubMed] [Google Scholar]
  63. Hill D. R., Benak S. B., Phillips T. L., Price D. C. Bone marrow regeneration following fractionated radiation therapy. Int J Radiat Oncol Biol Phys. 1980 Sep;6(9):1149–1155. doi: 10.1016/0360-3016(80)90167-4. [DOI] [PubMed] [Google Scholar]
  64. Holm G., Mellstedt H., Pettersson D., Biberfeld R. Idiotypic immunoglobulin structures on blood lymphocytes in human plasma cell myeloma. Immunol Rev. 1977;34:139–164. doi: 10.1111/j.1600-065x.1977.tb00371.x. [DOI] [PubMed] [Google Scholar]
  65. Hull M. T., Griep J. A. Mixed leukemia, lymphatic and myelomonocytic. Am J Clin Pathol. 1980 Oct;74(4):473–475. doi: 10.1093/ajcp/74.4.473. [DOI] [PubMed] [Google Scholar]
  66. Hyun B. H., Kwa D., Gabaldon H., Ashton J. K. Reactive plasmacytic lesions of the bone marrow. Am J Clin Pathol. 1976 Jun;65(6):921–928. doi: 10.1093/ajcp/65.6.921. [DOI] [PubMed] [Google Scholar]
  67. Ironside P., Cornell F. N. Immunoblastic lymphadenopathy. A clinico-pathological study of 16 cases. Pathology. 1979 Jan;11(1):27–37. doi: 10.3109/00313027909063534. [DOI] [PubMed] [Google Scholar]
  68. Islam A., Catovsky D., Galton D. A. Histological study of bone marrow regeneration following chemotherapy for acute myeloid leukaemia and chronic granulocytic leukaemia in blast transformation. Br J Haematol. 1980 Aug;45(4):535–540. doi: 10.1111/j.1365-2141.1980.tb07175.x. [DOI] [PubMed] [Google Scholar]
  69. Jamshidi K., Swaim W. R. Bone marrow biopsy with unaltered architecture: a new biopsy device. J Lab Clin Med. 1971 Feb;77(2):335–342. [PubMed] [Google Scholar]
  70. Joyner M. V., Cassuto J. P., Dujardin P., Schneider M., Ziegler G., Euller L., Masseyeff R. Non-excretory multiple myeloma. Br J Haematol. 1979 Dec;43(4):559–566. doi: 10.1111/j.1365-2141.1979.tb03788.x. [DOI] [PubMed] [Google Scholar]
  71. Katayama I., Yang J. P. Tartrate-resistant acid phosphatase reactions not specific for hairy cell leukemia. Am J Clin Pathol. 1979 Apr;71(4):482–482. doi: 10.1093/ajcp/71.4.482. [DOI] [PubMed] [Google Scholar]
  72. Kelemen E., Krasznai G., Endes P., Szinay G. Chronic idiopathic myelofibrosis. A reversible disease?. Acta Haematol. 1977;57(3):171–177. doi: 10.1159/000207878. [DOI] [PubMed] [Google Scholar]
  73. Kerndrup G., Pallesen G., Melsen F., Mosekilde L. Histomorphometrical determination of bone marrow cellularity in iliac crest biopsies. Scand J Haematol. 1980 Feb;24(2):110–114. doi: 10.1111/j.1600-0609.1980.tb02353.x. [DOI] [PubMed] [Google Scholar]
  74. Kitchens C. S. Clinical observations of human bone marrow macrophages. Medicine (Baltimore) 1977 Nov;56(6):503–513. doi: 10.1097/00005792-197711000-00005. [DOI] [PubMed] [Google Scholar]
  75. Koeffler H. P., Golde D. W. Human preleukemia. Ann Intern Med. 1980 Aug;93(2):347–353. doi: 10.7326/0003-4819-93-2-347. [DOI] [PubMed] [Google Scholar]
  76. Korman L. Y., Smith J. R., Landaw S. A., Davey F. R. Hodgkin's disease: intramedullary phagocytosis with pancytopenia. Ann Intern Med. 1979 Jul;91(1):60–61. doi: 10.7326/0003-4819-91-1-60. [DOI] [PubMed] [Google Scholar]
  77. Kosmidis P. A., Palacas C. G., Axelrod A. R. Diffuse purely osteolytic lesions in myelofibrosis. Cancer. 1980 Nov 15;46(10):2263–2265. doi: 10.1002/1097-0142(19801115)46:10<2263::aid-cncr2820461025>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  78. Krause J. R., Brubaker D., Kaplan S. Comparison of stainable iron in aspirated and needle-biopsy specimens of bone marrow. Am J Clin Pathol. 1979 Jul;72(1):68–70. doi: 10.1093/ajcp/72.1.68. [DOI] [PubMed] [Google Scholar]
  79. Krause J. R., Stolc V. Serum ferritin and bone marrow biopsy iron stores. II. Correlation with low serum iron and Fe/TIBC ratio less than 15%. Am J Clin Pathol. 1980 Oct;74(4):461–464. doi: 10.1093/ajcp/74.4.461. [DOI] [PubMed] [Google Scholar]
  80. Kurnick J. E., Mahmood T., Napoli N., Block M. H. Extension of myeloid tissue into the lower extremities in polycythemia. Am J Clin Pathol. 1980 Oct;74(4):427–431. doi: 10.1093/ajcp/74.4.427. [DOI] [PubMed] [Google Scholar]
  81. Landys K., Stenram U. Bone marrow biopsy of the posterior iliac crest with Gidlund's instrument in malignant diseases. Scand J Haematol. 1975 Sep;15(2):104–108. doi: 10.1111/j.1600-0609.1975.tb01061.x. [DOI] [PubMed] [Google Scholar]
  82. Lee C. H., Morris T. C. Bone marrow necrosis and extramedullary myeloid tumour necrosis in aggressive chronic myeloid leukaemia. Pathology. 1979 Jul;11(3):551–556. doi: 10.3109/00313027909059030. [DOI] [PubMed] [Google Scholar]
  83. Leimert J. T., Armitage J. O., Dick F. R. Myeloid metaplasia and osteolytic lesions. Am J Clin Pathol. 1978 Oct;70(4):706–708. doi: 10.1093/ajcp/70.4.706. [DOI] [PubMed] [Google Scholar]
  84. Leimert J. T., Burns C. P., Wiltse C. G., Armitage J. O., Clarke W. R. Prognostic influence of pretreatment characteristics in adult acute lymphoblastic leukemia. Blood. 1980 Sep;56(3):510–515. [PubMed] [Google Scholar]
  85. Lennert K., Parwaresch M. R. Mast cells and mast cell neoplasia: a review. Histopathology. 1979 Sep;3(5):349–365. doi: 10.1111/j.1365-2559.1979.tb03017.x. [DOI] [PubMed] [Google Scholar]
  86. Levine A. M., Lichtenstein A., Gresik M. V., Taylor C. R., Feinstein D. I., Lukes R. J. Clinical and immunologic spectrum of plasmacytoid lymphocytic lymphoma without serum monoclonal IgM. Br J Haematol. 1980 Oct;46(2):225–233. doi: 10.1111/j.1365-2141.1980.tb05961.x. [DOI] [PubMed] [Google Scholar]
  87. Leyssen M. H., Verwilghen R. L. Diagnosis of bone marrow necrosis. Clin Lab Haematol. 1979;1(3):197–202. doi: 10.1111/j.1365-2257.1979.tb00468.x. [DOI] [PubMed] [Google Scholar]
  88. Lipshutz M. D., Mir R., Rai K. R., Sawitsky A. Bone marrow biopsy and clinical staging in chronic lymphocytic leukemia. Cancer. 1980 Sep 15;46(6):1422–1427. doi: 10.1002/1097-0142(19800915)46:6<1422::aid-cncr2820460623>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  89. Lukes R. J. Criteria for involvement of lymph node, bone marrow, spleen, and liver in Hodgkin's disease. Cancer Res. 1971 Nov;31(11):1755–1767. [PubMed] [Google Scholar]
  90. Lukes R. J., Parker J. W., Taylor C. R., Tindle B. H., Cramer A. D., Lincoln T. L. Immunologic approach to non-Hodgkin lymphomas and related leukemias. Analysis of the results of multiparameter studies of 425 cases. Semin Hematol. 1978 Oct;15(4):322–351. [PubMed] [Google Scholar]
  91. Mann R. B., Jaffe E. S., Berard C. W. Malignant lymphomas--a conceptual understanding of morphologic diversity. A review. Am J Pathol. 1979 Jan;94(1):105–192. [PMC free article] [PubMed] [Google Scholar]
  92. Manoharan A., Horsley R., Pitney W. R. The reticulin content of bone marrow in acute leukaemia in adults. Br J Haematol. 1979 Oct;43(2):185–190. doi: 10.1111/j.1365-2141.1979.tb03740.x. [DOI] [PubMed] [Google Scholar]
  93. McMillan P., Mundy G., Mayer P. Hypercalcaemia and osteolytic bone lesions in chronic lymphocytic leukaemia. Br Med J. 1980 Oct 25;281(6248):1107–1107. doi: 10.1136/bmj.281.6248.1107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Mennemeyer R. P., Kjeldsberg C. R. Isolated lymphoid hyperplasia of the bone marrow simulating malignant lymphoma. Am J Clin Pathol. 1976 Jan;65(1):45–48. doi: 10.1093/ajcp/65.1.45. [DOI] [PubMed] [Google Scholar]
  95. Mertelsmann R., Tzvi Thaler H., To L., Gee T. S., McKenzie S., Schauer P., Friedman A., Arlin Z., Cirrincione C., Clarkson B. Morphological classification, response to therapy, and survival in 263 adult patients with acute nonlymphoblastic leukemia. Blood. 1980 Nov;56(5):773–781. [PubMed] [Google Scholar]
  96. Milder M. S., Cook J. D., Stray S., Finch C. A. Idiopathic hemochromatosis, an interim report. Medicine (Baltimore) 1980 Jan;59(1):34–49. doi: 10.1097/00005792-198001000-00002. [DOI] [PubMed] [Google Scholar]
  97. Mora J. J., Heron J. F., L'Hirondel J. L., Loyau G. Lésion ostéolytique au cours de la leucémie myéloïde chronique. Nouv Presse Med. 1979 Oct 15;8(39):3171–3171. [PubMed] [Google Scholar]
  98. Morgan E., Pang K. M., Goldwasser E. Hodgkin disease and red cell aplasia. Am J Hematol. 1978;5(1):71–75. doi: 10.1002/ajh.2830050110. [DOI] [PubMed] [Google Scholar]
  99. Mundy G. R., Raisz L. G., Cooper R. A., Schechter G. P., Salmon S. E. Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med. 1974 Nov 14;291(20):1041–1046. doi: 10.1056/NEJM197411142912001. [DOI] [PubMed] [Google Scholar]
  100. Nathwani B. N. A critical analysis of the classifications of non-Hodgkin's lymphomas. Cancer. 1979 Aug;44(2):347–384. doi: 10.1002/1097-0142(197908)44:2<347::aid-cncr2820440202>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  101. Nawab R. A., Azar H. A. The laboratory diagnosis of plasma cell myeloma and related disorders. Orthop Clin North Am. 1979 Apr;10(2):391–404. [PubMed] [Google Scholar]
  102. Noseda G., Reiner M., Scali G. Haarzell-Leukämie und Myelom. Schweiz Med Wochenschr. 1980 Oct 11;110(41):1494–1498. [PubMed] [Google Scholar]
  103. Okita H., Block M. Osteomalacic new bone formation during chemotherapy of acute granulocytic leukemia. Am J Clin Pathol. 1979 Jun;71(6):645–650. doi: 10.1093/ajcp/71.6.645. [DOI] [PubMed] [Google Scholar]
  104. Olah A. J., Simon A., Gaudy M., Herrmann W., Schenk R. K. Differential staining of calcified tissues in plastic embedded microtome sections by a modification of Movat's pentachrome stain. Stain Technol. 1977 Nov;52(6):331–337. doi: 10.3109/10520297709116809. [DOI] [PubMed] [Google Scholar]
  105. Owen M. The origin of bone cells in the postnatal organism. Arthritis Rheum. 1980 Oct;23(10):1073–1080. doi: 10.1002/art.1780231002. [DOI] [PubMed] [Google Scholar]
  106. Pangalis G. A., Moran E. M., Rappaport H. Blood and bone marrow findings in angioimmunoblastic lymphadenopathy. Blood. 1978 Jan;51(1):71–83. [PubMed] [Google Scholar]
  107. Patel A. R., Shah P. C., Rhee H. L. Acute myelofibrosis and acute myeloblastic leukaemia. Br Med J. 1976 Nov 20;2(6046):1232–1232. doi: 10.1136/bmj.2.6046.1232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Pearl E. R., Vogler L. B., Okos A. J., Crist W. M., Lawton A. R., 3rd, Cooper M. D. B lymphocyte precursors in human bone marrow: an analysis of normal individuals and patients with antibody-deficiency states. J Immunol. 1978 Apr;120(4):1169–1175. [PubMed] [Google Scholar]
  109. Pettit J. E., Lewis S. M., Nicholas A. W. Transitional myeloproliferative disorder. Br J Haematol. 1979 Oct;43(2):167–184. doi: 10.1111/j.1365-2141.1979.tb03739.x. [DOI] [PubMed] [Google Scholar]
  110. Polliack A., Prokocimer M., Matzner Y. Lymphoblastic leukemic transformation (lymphoblastic crisis) in myelofibrosis and myeloid metaplasia. Am J Hematol. 1980;9(2):211–220. doi: 10.1002/ajh.2830090209. [DOI] [PubMed] [Google Scholar]
  111. Presentey B., Jerushalmy Z., Mintz U. Eosinophilic leukaemia: morphological, cytochemical, and electron microscopic studies. J Clin Pathol. 1979 Mar;32(3):261–271. doi: 10.1136/jcp.32.3.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Rai K. R., Sawitsky A., Cronkite E. P., Chanana A. D., Levy R. N., Pasternack B. S. Clinical staging of chronic lymphocytic leukemia. Blood. 1975 Aug;46(2):219–234. [PubMed] [Google Scholar]
  113. Raina V. Normal osteoid tissue. J Clin Pathol. 1972 Mar;25(3):229–232. doi: 10.1136/jcp.25.3.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  114. Raisz L. G. What marrow does to bone. N Engl J Med. 1981 Jun 11;304(24):1485–1486. doi: 10.1056/NEJM198106113042410. [DOI] [PubMed] [Google Scholar]
  115. Rassiga A. L. Advances in adult non-Hodgkin's lymphoma. Current concepts of classification, diagnosis, and management. Arch Intern Med. 1980 Dec;140(12):1647–1651. [PubMed] [Google Scholar]
  116. Ratnoff W. D., Gress R. E. The familial occurrence of polycythemia vera: report of a father and son, with consideration of the possible etiologic role of exposure to organic solvents, including tetrachloroethylene. Blood. 1980 Aug;56(2):233–236. [PubMed] [Google Scholar]
  117. Reimer R. R., Chabner B. A., Young R. C., Reddick R., Johnson R. E. Lymphoma presenting in bone: results of histopathology, staging, and therapy. Ann Intern Med. 1977 Jul;87(1):50–55. doi: 10.7326/0003-4819-87-1-50. [DOI] [PubMed] [Google Scholar]
  118. Risdall R., Hoppe R. T., Warnke R. Non-Hodgkin's lymphoma: a study of the evolution of the disease based upon 92 autopsied cases. Cancer. 1979 Aug;44(2):529–542. doi: 10.1002/1097-0142(197908)44:2<529::aid-cncr2820440222>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  119. Rizzo S. C., Fontana G., Ricevuti G., Balduini C. L. Osteolytic lesions in chronic granulocytic leukemia: a report of four cases. Haematologica. 1977 Feb;62(1):61–74. [PubMed] [Google Scholar]
  120. Roberts B. E., Woods C. G., Miles D. W., Paterson C. R. Bone changes in polycythaemia vera and myelosclerosis. J Clin Pathol. 1969 Nov;22(6):696–700. doi: 10.1136/jcp.22.6.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Robertson J. H., Burnside P., Salmon D. C. Marrow hypoplasia with splenomegaly in adolescence. J Clin Pathol. 1980 Aug;33(8):730–734. doi: 10.1136/jcp.33.8.730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Rosenberg S. A. Current concepts in cancer: non-Hodgkin's lymphoma--selection of treatment on the basis of histologic type. N Engl J Med. 1979 Oct 25;301(17):924–928. doi: 10.1056/NEJM197910253011706. [DOI] [PubMed] [Google Scholar]
  123. Roth D. G., Richman C. M., Rowley J. D. Chronic myelodysplastic syndrome (preleukemia) with the Philadelphia chromosome. Blood. 1980 Aug;56(2):262–264. [PubMed] [Google Scholar]
  124. Rowe D. J., Hausmann E. Quantitative analyses of osteoclast changes in resorbing bone organ cultures. Calcif Tissue Res. 1977 Oct 20;23(3):283–289. doi: 10.1007/BF02012798. [DOI] [PubMed] [Google Scholar]
  125. Rywlin A. M., Ortega R. S., Dominguez C. J. Lymphoid nodules of bone marrow: normal and abnormal. Blood. 1974 Mar;43(3):389–400. [PubMed] [Google Scholar]
  126. Safai B., Good R. A. Lymphoproliferative disorders of the T-cell series. A review. Medicine (Baltimore) 1980 Sep;59(5):335–351. doi: 10.1097/00005792-198009000-00002. [DOI] [PubMed] [Google Scholar]
  127. Schnaidt U., Vykoupil K. F., Thiele J., Georgii A. Angioimmunoblastic lymphadenopathy. Histopathology of bone marrow involvement. Virchows Arch A Pathol Anat Histol. 1980;389(3):369–380. doi: 10.1007/BF00430660. [DOI] [PubMed] [Google Scholar]
  128. Silver B. J., Zuckerman K. S. Aplastic anemia: recent advances in pathogenesis and treatment. Med Clin North Am. 1980 Jul;64(4):607–629. doi: 10.1016/s0025-7125(16)31584-x. [DOI] [PubMed] [Google Scholar]
  129. Silverstein M. N., ReMine W. H. Splenectomy in myeloid metaplasia. Blood. 1979 Mar;53(3):515–518. [PubMed] [Google Scholar]
  130. Sjögren U. Morphologic studies of the erythropoietic part of bone marrow in myeloid leukaemias. Scand J Haematol. 1979 Jan;22(1):61–66. doi: 10.1111/j.1600-0609.1979.tb00402.x. [DOI] [PubMed] [Google Scholar]
  131. Staples W. G., Gétaz E. P. Bone marrow involvement in malignant lymphoma without peripheral lymphadenopathy. S Afr Med J. 1977 Jul 9;52(2):60–63. [PubMed] [Google Scholar]
  132. Straus D. J., Mertelsmann R., Koziner B., McKenzie S., de Harven E., Arlin Z. A., Kempin S., Broxmeyer H., Moore M. A., Menendez-Botet C. J. The acute monocytic leukemias: multidisciplinary studies in 45 patients. Medicine (Baltimore) 1980 Nov;59(6):409–425. doi: 10.1097/00005792-198011000-00002. [DOI] [PubMed] [Google Scholar]
  133. Streuli R. A., Testa J. R., Vardiman J. W., Mintz U., Golomb H. M., Rowley J. D. Dysmyelopoietic syndrome: sequential clinical and cytogenetic studies. Blood. 1980 Apr;55(4):636–644. [PubMed] [Google Scholar]
  134. Stuart A. E. The pathogenesis of Hodgkin's disease. J Pathol. 1978 Dec;126(4):239–254. doi: 10.1002/path.1711260408. [DOI] [PubMed] [Google Scholar]
  135. Sullivan R., Quesenberry P. J., Parkman R., Zuckerman K. S., Levey R. H., Rappeport J., Ryan M. Aplastic anemia: lack of inhibitory effect of bone marrow lymphocytes on in vitro granulopoiesis. Blood. 1980 Oct;56(4):625–632. [PubMed] [Google Scholar]
  136. Taberner D. A., Chang J., Otridge B. W. Co-existent chronic lymphatic leukaemia with polycythaemia vera. Postgrad Med J. 1977 Apr;53(618):222–223. doi: 10.1136/pgmj.53.618.222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Tachibana F., Hakozaki H., Takahashi K., Kojima M., Enomoto S., Wada J. Syndrome of the sea-blue histiocyte--the first case report in Japan and review of the literature--. Acta Pathol Jpn. 1979 Jan;29(1):73–97. doi: 10.1111/j.1440-1827.1979.tb01294.x. [DOI] [PubMed] [Google Scholar]
  138. Tavassoli M. The marrow-blood barrier. Br J Haematol. 1979 Mar;41(3):297–302. doi: 10.1111/j.1365-2141.1979.tb05862.x. [DOI] [PubMed] [Google Scholar]
  139. Thiele J., Vykoupil K. F., Georgii A. Chronic myelomonocytic leukemia: light and electron microscopy of the bone marrow. Blut. 1979 Sep;39(3):177–190. doi: 10.1007/BF01008447. [DOI] [PubMed] [Google Scholar]
  140. Thiele J., Vykoupil K. F., Georgii A. Myeloid dysplasia (MD): a hematological disorder preceding acute and chronic myeloid leukemia. A morphological study on sequential core biopsies of the bone marrow in 27 patients. Virchows Arch A Pathol Anat Histol. 1980;389(3):343–367. doi: 10.1007/BF00430659. [DOI] [PubMed] [Google Scholar]
  141. Thiele J., Vykoupil K. F., Georgii A. Ultrastructure of blastic crisis in osteomyelofibrosis. A report of 2 cases with some unusual features. Virchows Arch A Pathol Anat Histol. 1980;389(3):287–305. doi: 10.1007/BF00430656. [DOI] [PubMed] [Google Scholar]
  142. Tobelem G., Jacquillat C., Chastang C., Auclerc M. F., Lechevallier T., Weil M., Daniel M. T., Flandrin G., Harrousseau J. L., Schaison G. Acute monoblastic leukemia: a clinical and biologic study of 74 cases. Blood. 1980 Jan;55(1):71–76. [PubMed] [Google Scholar]
  143. Turner A., Kjeldsberg C. R. Hairy cell leukemia: a review. Medicine (Baltimore) 1978 Nov;57(6):477–499. doi: 10.1097/00005792-197811000-00001. [DOI] [PubMed] [Google Scholar]
  144. Velde J. T., Burkhardt R., Kleiverda K., Leenheers-Binnendijk L., Sommerfeld W. Methyl-methacrylate as an embedding medium in histopathology. Histopathology. 1977 Sep;1(5):319–330. doi: 10.1111/j.1365-2559.1977.tb01671.x. [DOI] [PubMed] [Google Scholar]
  145. Viana M. B., Maurer H. S., Ferenc C. Subclassification of acute lymphoblastic leukaemia in children: analysis of the reproducibility of morphological criteria and prognostic implications. Br J Haematol. 1980 Mar;44(3):383–388. doi: 10.1111/j.1365-2141.1980.tb05907.x. [DOI] [PubMed] [Google Scholar]
  146. Villeneuve B. Mode de terminaison de la leucémie lymphoïde chronique--syndrome de Richter. Union Med Can. 1976 Feb;105(2):255–257. [PubMed] [Google Scholar]
  147. Vykoupil K. F., Thiele J., Stangel W., Krmpotic E., Georgii A. Polycythemia vera. I. Histopathology, ultrastructure and cytogenetics of the bone marrow in comparison with secondary polycythemia. Virchows Arch A Pathol Anat Histol. 1980;389(3):307–324. doi: 10.1007/BF00430657. [DOI] [PubMed] [Google Scholar]
  148. Vykoupil K. F., Thiele J., Stangel W., Krmpotic E., Georgii A. Polycythemia vera. II. Transgression towards leukemia with special emphasis on histological differential diagnosis, cytogenetics and survival. Virchows Arch A Pathol Anat Histol. 1980;389(3):325–341. doi: 10.1007/BF00430658. [DOI] [PubMed] [Google Scholar]
  149. Walter R. M., Jr, Greenberg B. R. Hypercalcemia in the accelerated phase of chronic myelogenous leukemia. Cancer. 1980 Sep 1;46(5):1174–1178. doi: 10.1002/1097-0142(19800901)46:5<1174::aid-cncr2820460516>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  150. Ward H. P., Block M. H. The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome. Medicine (Baltimore) 1971 Sep;50(5):357–420. doi: 10.1097/00005792-197109000-00001. [DOI] [PubMed] [Google Scholar]
  151. Weisenburger D. D. Acute myelofibrosis terminating as acute myeloblastic leukemia. Am J Clin Pathol. 1980 Jan;73(1):128–132. doi: 10.1093/ajcp/73.1.128. [DOI] [PubMed] [Google Scholar]
  152. Werts E. D., Gibson D. P., Degowin R. L. Chronic inflammation suppresses bone marrow stromal cells and medullary erythropoiesis. J Lab Clin Med. 1979 Jun;93(6):995–1003. [PubMed] [Google Scholar]
  153. Whitehouse W. J. Cancellous bone in the anterior part of the iliac crest. Calcif Tissue Res. 1977 May 31;23(1):67–76. doi: 10.1007/BF02012768. [DOI] [PubMed] [Google Scholar]
  154. Whittaker J. A., Reizenstein P., Callender S. T., Cornwell G. G., Delamore I. W., Gale R. P., Gobbi M., Jacobs P., Lantz B., Maiolo A. T. Long survival in acute myelogenous leukaemia: an international collaborative study. Br Med J (Clin Res Ed) 1981 Feb 28;282(6265):692–695. doi: 10.1136/bmj.282.6265.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Yeung K., Trowbridge A. A. Idiopathic acquired sideroblastic anemia terminating in acute myelofibrosis: case report and review of leterature. Cancer. 1977 Jan;39(1):359–365. doi: 10.1002/1097-0142(197701)39:1<359::aid-cncr2820390155>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  156. You W., Weisbrot I. M. Chronic neutrophilic leukemia. Report of two cases and review of the literature. Am J Clin Pathol. 1979 Aug;72(2):233–242. doi: 10.1093/ajcp/72.2.233. [DOI] [PubMed] [Google Scholar]
  157. Zambernard J., Block M., Vatter A., Trenner L. An adaptation of methacrylate embedding for routine histopathologic use. Blood. 1969 Mar;33(3):444–450. [PubMed] [Google Scholar]
  158. van Rhenen D. J., Verhulst J. C., Huijgens P. C., Langenhuijsen M. M. Maturation index: a contribution to quantification in the FAB classification of acute leukaemia. Br J Haematol. 1980 Dec;46(4):581–586. doi: 10.1111/j.1365-2141.1980.tb06015.x. [DOI] [PubMed] [Google Scholar]

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