Abstract
A 70-year-old woman presented with back pain due to vertebral crush fractures and was found to have hypercalcaemia. Investigation revealed evidence of both primary hyperparathyroidism and Bence Jones myeloma and this was subsequently confirmed at necropsy. This is the first description of a case in which the simultaneous occurrence of both diseases was reliably established. The case illustrates the difficulty in identifying the cause of hypercalcaemia in some patients, and emphasises the need to consider the diagnosis of myeloma in all cases of hypercalcaemia.
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- Dexter R. N., Mullinax F., Estep H. L., Williams R. C., Jr Monoclonal IgG gammopathy and hyperparathyroidism. Ann Intern Med. 1972 Nov;77(5):759–764. doi: 10.7326/0003-4819-77-5-759. [DOI] [PubMed] [Google Scholar]
- Fisken R. A., Heath D. A., Somers S., Bold A. M. Hypercalcaemia in hospital patients. Clinical and diagnostic aspects. Lancet. 1981 Jan 24;1(8213):202–207. doi: 10.1016/s0140-6736(81)90071-4. [DOI] [PubMed] [Google Scholar]
- Galton D. A., Peto R. A progress report on the Medical Research Council's therapeutic trial in myelomatosis. Br J Haematol. 1968 Sep;15(3):319–320. [PubMed] [Google Scholar]
- Heath H., 3rd, Hodgson S. F., Kennedy M. A. Primary hyperparathyroidism. Incidence, morbidity, and potential economic impact in a community. N Engl J Med. 1980 Jan 24;302(4):189–193. doi: 10.1056/NEJM198001243020402. [DOI] [PubMed] [Google Scholar]
- Jackson R. M., Orland M. J. Parathyroid adenoma in a patient with multiple myeloma. South Med J. 1979 Oct;72(10):1336–1337. doi: 10.1097/00007611-197910000-00034. [DOI] [PubMed] [Google Scholar]
- Stewart A. F., Horst R., Deftos L. J., Cadman E. C., Lang R., Broadus A. E. Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and nonhumoral groups. N Engl J Med. 1980 Dec 11;303(24):1377–1383. doi: 10.1056/NEJM198012113032401. [DOI] [PubMed] [Google Scholar]